Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Eike Floettmann"'
Publikováno v:
Toxicology and Applied Pharmacology. 329:85-95
Naloxegol is an opioid antagonist which has been developed for the treatment of patients with opioid induced constipation. In the nonclinical safety program naloxegol was shown to have a very benign toxicity profile. In the rat, but not the mouse, 2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01b39b65154a068a099cef6e6c2701f
https://doi.org/10.1016/j.taap.2017.05.032
https://doi.org/10.1016/j.taap.2017.05.032
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
Opioid-induced constipation (OIC) is a common side effect of opioid pharmacotherapy for the management of pain because opioid agonists bind to µ-opioid receptors in the enteric nervous system (ENS). Naloxegol, a polyethylene glycol derivative of nal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6edd2237c3326b61030cc92d395344
https://doi.org/10.1124/jpet.116.239061
https://doi.org/10.1124/jpet.116.239061
Publikováno v:
Clinical Pharmacokinetics. 56:573-582
Naloxegol is a peripherally acting µ-opioid receptor antagonist approved for use as an orally administered tablet (therapeutic doses of 12.5 and 25 mg) for the treatment of opioid-induced constipation. Over a wide dose range (i.e. single supratherap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f24132214caf1db2e1d1d5746d6209e8
https://doi.org/10.1007/s40262-016-0479-z
https://doi.org/10.1007/s40262-016-0479-z
Autor:
Rowe, Martin, Eike Floettmann, J.
Publikováno v:
DNA Virus Replication.
Externí odkaz:
https://doi.org/10.1093/oso/9780199637133.003.0004
Autor:
Tim J.D. Smith, Alan Martin Birch, Andrew V. Turnbull, Huw B. Jones, Linda K. Buckett, Jan Eike Floettmann, Carina Hallberg, David Lees
Publikováno v:
Toxicologic Pathology. 41:941-950
Acyl-coenzyme A: cholesterol O-Acyltransferase (ACAT) and Acyl-coenzyme A: diacylglycerol O-acyltransferase (DGAT) enzymes play important roles in synthesizing neutral lipids, and inhibitors of these enzymes have been investigated as potential treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90aef9c324ddcb52f3eb6483b8a489bb
https://doi.org/10.1177/0192623313477753
https://doi.org/10.1177/0192623313477753
Autor:
Simon M. Poucher, John Myatt, Joanne Teague, Laraine Gregory, Eike Floettmann, Clare D. Hammond, Huw B. Jones
Publikováno v:
Toxicologic Pathology. 38:393-401
The preclinical efficacy and safety of GPi921, a glycogen phosphorylase inhibitor, was assessed following twenty-eight days of administration to Zucker Diabetic Fatty (ZDF) rats. The ZDF rat is an animal model of type 2 diabetes mellitus (TTDM) which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1578f4707cf803e0a6ca618d0c5c22c6
https://doi.org/10.1177/0192623310362707
https://doi.org/10.1177/0192623310362707
Autor:
Paul Brennan, Martin Rowe, Sinead Keating, Ceri Alan Fielding, Eike Floettmann, Stuart Prince
Publikováno v:
Journal of Virology. 77:5000-5007
Epstein-Barr virus (EBV) is a potent growth-transforming agent of human B cells. It has previously been shown that viral latent membrane protein 1 (LMP1) is essential for EBV-induced transformation of normal B cells and contributes to maintenance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b7f0e774de8cac17eded8e943ee3e5
https://doi.org/10.1128/jvi.77.8.5000-5007.2003
https://doi.org/10.1128/jvi.77.8.5000-5007.2003
Autor:
Peter K. Djali, John Unitt, Michael R. H. White, Geraint J. C. Wilde, Luminita Paraoan, David G. Spiller, Eike Floettmann, Glyn Nelson, Elaine Sullivan, Mark Browne
Publikováno v:
Journal of Cell Science. 115:1137-1148
Proteins of the NF-kappaB transcription factor family normally reside in the cytoplasm of cells in a complex with IkappaB inhibitor proteins. Stimulation with TNFalpha leads to proteosomal degradation of the IkappaB proteins and nuclear translocation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37728418723e64a3d62200564af450f6
https://doi.org/10.1242/jcs.115.6.1137
https://doi.org/10.1242/jcs.115.6.1137
Publikováno v:
Toxicologic pathology. 43(3)
Diacylglycerol O-acyltransferase 1 (DGAT1) plays an important role in synthesizing lipids, and inhibitors of DGAT1 have been investigated as potential treatments for diabetes and metabolic diseases. DGAT1 knockout (−/−) mice are resistant to obes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63863b64940632f627067953c543ecd1
https://pubmed.ncbi.nlm.nih.gov/25112279
https://pubmed.ncbi.nlm.nih.gov/25112279
Publikováno v:
Journal of Biological Chemistry. 276:984-992
The latent membrane protein-1 (LMP1) of Epstein-Barr virus induces gene transcription, phenotypic changes, and oncogenic transformation. One cellular gene induced by LMP1 is that for intercellular adhesion molecule-1 (ICAM-1), which participates in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c478a5e0b02463862856e166d5f2907
https://doi.org/10.1074/jbc.m003758200
https://doi.org/10.1074/jbc.m003758200