Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Eika Higashi"'
Autor:
Yuka Uenohara, Saori Tsumura, Shigeto Hirayama, Eika Higashi, Yurie Watanabe, Hiroaki Gouda, Hiroshi Nagase, Hideaki Fujii
Publikováno v:
Bioorganicmedicinal chemistry. 53
The κ opioid receptor (KOR) is one of the promising targets to develop analgesics lacking morphine like side effects. To seek a novel KOR agonist we designed 6-amide derivatives with an oxabicyclo[3.2.1]octane structure based on a proposed active co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281db4186b3e8de01a53d2d689f42efb
https://pubmed.ncbi.nlm.nih.gov/34894610
https://pubmed.ncbi.nlm.nih.gov/34894610
Autor:
Toru Nemoto, Kennosuke Itoh, Hideaki Fujii, Takashi Iwai, Chiharu Iwamatsu, Mitsuo Tanabe, Eika Higashi, Shigeto Hirayama, Minami Nakamura
Publikováno v:
ACS Chemical Neuroscience. 10:2237-2242
The cyclopropylmethyl group in classical δ opioid receptor (DOR) antagonist NTI, BNTX, and NTB was replaced with various electron-withdrawing groups to develop DOR inverse agonists. N-Benzyl NTB derivative SYK-657 was a potent DOR full inverse agoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d1b2a0ab7cd3f13b954e5f668b295e
https://doi.org/10.1021/acschemneuro.9b00067
https://doi.org/10.1021/acschemneuro.9b00067
Autor:
Kaoru Tayama, Shigeto Hirayama, Hideaki Fujii, Kennosuke Itoh, Fumika Karaki, Eika Higashi, Kyoko Ishikawa
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 65:920-929
Buprenorphine shows strong analgesic effects on moderate to severe pain. Although buprenorphine can be used more safely than other opioid analgesics, it has room for improvement in clinical utility. Investigation of compounds structurally related to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5db16b031482979ca2d566258de9f13d
https://doi.org/10.1248/cpb.c17-00385
https://doi.org/10.1248/cpb.c17-00385
Autor:
Tomomi Kono, Marie Shibasaki, Eika Higashi, Jun Nikaido, Shigeto Hirayama, Hiroko Ikeda, Hideaki Fujii, Junzo Kamei, Ayaka Honjo
Publikováno v:
ACS chemical neuroscience. 10(9)
Our previous results showed that naltrindole (NTI) derivatives with certain types of electron-withdrawing groups as an N-substituent showed δ opioid receptor (DOR) inverse agonistic activities. We therefore synthesized N-acylated NTI derivatives 3a-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee63c42f09af358c48fdb79ab252825f
https://pubmed.ncbi.nlm.nih.gov/31397148
https://pubmed.ncbi.nlm.nih.gov/31397148
Autor:
Shigeto Hirayama, Yusuke Iihara, Takashi Iwai, Hideaki Fujii, Toru Nemoto, Hiroshi Nagase, Eika Higashi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:2927-2930
We synthesized derivatives of the δ opioid receptor (DOR) antagonists naltrindole (NTI) and compound 1 that were modified with small alkyl or fluorinated ethyl substituents on the 17-nitrogen. Although the derivatives showed decreased binding affini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a09d107b212b94e6f056d303666e99
https://doi.org/10.1016/j.bmcl.2015.05.038
https://doi.org/10.1016/j.bmcl.2015.05.038
Autor:
Kyoko, Ishikawa, Fumika, Karaki, Kaoru, Tayama, Eika, Higashi, Shigeto, Hirayama, Kennosuke, Itoh, Hideaki, Fujii
Publikováno v:
Chemicalpharmaceutical bulletin. 65(10)
Buprenorphine shows strong analgesic effects on moderate to severe pain. Although buprenorphine can be used more safely than other opioid analgesics, it has room for improvement in clinical utility. Investigation of compounds structurally related to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::673e64efbf1202352a0da25d0402f305
https://pubmed.ncbi.nlm.nih.gov/28966276
https://pubmed.ncbi.nlm.nih.gov/28966276
Autor:
Shigeto Hirayama, Jun Nikaido, Hiroko Ikeda, Hideaki Fujii, Toru Nemoto, Junzo Kamei, Eika Higashi
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO4-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dfb8270b9a4bdef20f25ffacc22fece
https://doi.org/10.1254/jpssuppl.wcp2018.0_po4-1-1
https://doi.org/10.1254/jpssuppl.wcp2018.0_po4-1-1