Real-world safety and efficacy data of ipilimumab in Japanese radically unresectable malignant melanoma patients: A postmarketing surveillance

Autor: Hisashi Uhara, Naoya Yamazaki, Naoki Shakunaga, Tetsuya Tsuchida, Akira Komoto, Yoshio Kiyohara, Eijun Itakura, Keiko Maruyama

Publikováno v: The Journal of Dermatology

Treatment with immune checkpoint inhibitors has improved prognosis among patients with cutaneous melanoma, but there are still unmet medical needs in Japan, especially for mucosal melanoma and acral lentiginous melanoma (ALM) subtypes. Ipilimumab, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d3164b0dc3435e75da8f063cd7fc7e
https://pubmed.ncbi.nlm.nih.gov/32515086

Japanese real-world study of sequential nivolumab and ipilimumab treament in melanoma

Autor: Naoya Yamazaki, Yusuke Muto, Kenji Yokota, Hisashi Uhara, Ryuhei Okuyama, Osamu Yamasaki, Eijun Itakura, Hiroshi Koga, Teruaki Katayama, Junji Kato, Atsushi Tanemura, Tatsuya Kaji, Yoshio Kiyohara, Satoshi Fukushima, Masashi Akiyama, Arata Tsutsumida, Shusuke Yoshikawa, Azusa Miyashita

Publikováno v: The Journal of dermatologyReferences. 46(11)

To describe the treatment patterns of nivolumab and ipilimumab in Japan, a retrospective observational study was conducted in melanoma patients who received nivolumab and ipilimumab sequentially. Patients who received nivolumab and ipilimumab in comb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1f158c7db3f8c526252c4409980adee
https://pubmed.ncbi.nlm.nih.gov/31531895

RT in situ PCR detection of MART-1 and TRP-2 mRNA in formalin-fixed, paraffin-embedded tissues of melanoma and nevi

Autor: Eberhard Paul, Rong-Rong Huang, Alistair J. Cochran, Duan-Ren Wen, Peter H Wünsch, Eijun Itakura

Publikováno v: Itakura, Eijun; Huang, Rong-Rong; Wen, Duan-Ren; Paul, Eberhard; Wünsch, Peter H; & Cochran, Alistair J. (2008). RT in situ PCR detection of MART-1 and TRP-2 mRNA in formalin-fixed, paraffin-embedded tissues of melanoma and nevi.. Modern Pathology, 21(3), 326-333. doi: 10.1038/modpathol.3801008. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1fs8s10x

Melanoma antigen recognized by T cells 1 (MART-1) and tyrosinase-related protein-2 (TRP-2) are two useful markers for immunohistochemical detection of melanocytic tumors. However, these markers may be passively acquired (phagocytosed) rather than act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0fdcde4a0b005494bf7cea63beb65e
https://doi.org/10.1038/modpathol.3801008

Is sentinel node susceptibility to metastases related to nodal immune modulation?

Autor: Eijun Itakura, Rong-Rong Huang, Duan-Ren Wen, Albert Su, Alistair J. Cochran

Publikováno v: Cancer journal (Sudbury, Mass.). 21(1)

Sentinel lymph nodes (SLNs), the initial site of regional metastases, directly receive lymph containing immune-modulatory cytokines and tumor cells from primary melanomas. Immune-suppressed SLNs are ideal for studies of tissue susceptibility to metas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3511e6715cc06d7de6b9ef0b07c27d9c
https://pubmed.ncbi.nlm.nih.gov/25611779

Optimized assessment of sentinel lymph nodes for metastatic melanoma: Implications for regional surgery and overall treatment planning

Autor: Frank Luo, Alice A. Roberts, Eijun Itakura, Alistair J. Cochran, Duan-Ren Wen, Rong-Rong Huang, Scott W. Binder

Publikováno v: Annals of Surgical Oncology. 11:156S-161S

Correct identification of the sentinel node (SN) and accurate evaluation of this node's tumor status constitute the most precise technique for staging clinically localized cutaneous melanoma. However, even if tumor is present in the SN (as in approxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d87dc86af4a151c46ba00f2e470901e5
https://doi.org/10.1007/bf02523621