Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Eijiro Umemura"'
Autor:
Yasunari Otsuka, Eijiro Umemura, Yukimi Takamiya, Teruhisa Ishibashi, Chigusa Hayashi, Keiko Yamada, Masayuki Igarashi, Masakatsu Shibasaki, Yoshiaki Takahashi
Publikováno v:
ACS Infectious Diseases. 9:886-898
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2ea60faf910841febb9ea6ce6ad8709
https://doi.org/10.1021/acsinfecdis.2c00557
https://doi.org/10.1021/acsinfecdis.2c00557
Publikováno v:
Journal of Synthetic Organic Chemistry, Japan. 80:676-690
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa6f9d039d5431987407d0696af7df40
https://doi.org/10.5059/yukigoseikyokaishi.80.676
https://doi.org/10.5059/yukigoseikyokaishi.80.676
Autor:
Yoko Hirai, Ko Kumura, Keiko Yamada, Kazunori Maebashi, Yoshinari Wakiyama, Eijiro Umemura, Keiichi Ajito
Publikováno v:
The Journal of antibiotics. 74(2)
Methicillin-resistant Staphylococcus aureus (MRSA) is one of causative bacteria for hospital- and community-acquired infections. In order to overcome MRSA infection, we synthesized compound A, a lincomycin derivative, and evaluated the biological pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9156c6625ad1dd44b0ed886d533c2f59
https://pubmed.ncbi.nlm.nih.gov/33060814
https://pubmed.ncbi.nlm.nih.gov/33060814
Autor:
Yasuo Sato, Eijiro Umemura, Yoko Hirai, Ko Kumura, Yoshinari Wakiyama, Kazutaka Ueda, Keiichi Ajito, Yoshio Hayashi, Satomi Masaki
Publikováno v:
The Journal of Antibiotics. 71:298-317
In order to modify lincomycin at the C-6 and C-7 positions, we prepared target molecules, which have substituted pipecolinic acid at the 6-amino group and a para-substituted phenylthio group at the C-7 position, in application of palladium-catalyzed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc586fd372d58d38de8c60161665f50f
https://doi.org/10.1038/ja.2017.114
https://doi.org/10.1038/ja.2017.114
Autor:
Takashi Watanabe, Takuji Yoshida, Mikio Yamamoto, Kazutaka Ueda, Keiichi Ajito, Ko Kumura, Yoshinari Wakiyama, Eijiro Umemura
Publikováno v:
The Journal of Antibiotics. 71:104-112
Lincomycin derivatives that have a 5-(2-nitrophenyl)-1,3,4-thiadiazol-2-yl thio moiety at the 7-position were synthesized. 5-Substituted 2-nitrophenyl derivatives showed potent antibacterial activities against Streptococcus pneumoniae and Streptococc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50119b25541bda82f51bc76fb993a7b8
https://doi.org/10.1038/ja.2017.59
https://doi.org/10.1038/ja.2017.59
Autor:
Eijiro Umemura, Yoshinari Wakiyama, Ko Kumura, Kazutaka Ueda, Hideki Fushimi, Takashi Watanabe, Keiichi Ajito, Eiki Shitara, Takuji Yoshida
Publikováno v:
The Journal of Antibiotics. 69:440-445
The synthesis and antibacterial activity of (7S)-7-sulfur-azetidin-3-yl lincomycin derivatives are described. Modification was achieved by a simple reaction of (7R)-7-O-methanesulfonyllincomycin and the corresponding substituted azetidine-2-thiol. Se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d30e339fef0c158e12c0979528c074
https://doi.org/10.1038/ja.2015.134
https://doi.org/10.1038/ja.2015.134
Autor:
Takashi Watanabe, Ko Kumura, Kazutaka Ueda, Keiichi Ajito, Eijiro Umemura, Yoko Hirai, Satomi Masaki, Mikio Yamamoto, Yoshinari Wakiyama
Publikováno v:
The Journal of Antibiotics. 69:428-439
Lincomycin derivatives, which possess a hetero ring at the C-7 position via sulfur atom, were synthesized by three types of reactions: (1) Mitsunobu reaction of 2,3,4-tris-O-(trimethylsiliyl)lincomycin (1) with the corresponding thiol, (2) SN2 reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57854c431a0d959144b9a1a42e53390
https://doi.org/10.1038/ja.2015.125
https://doi.org/10.1038/ja.2015.125
Autor:
Ko Kumura, Kazutaka Ueda, Eijiro Umemura, Hideki Fushimi, Yoshinari Wakiyama, Megumi Kumura, Satomi Masaki, Keiichi Ajito
Publikováno v:
The Journal of Antibiotics. 69:368-380
We synthesized 7(S)-7-deoxy-7-arylthiolincomycin derivatives possessing a heterocyclic ring at the C-7 position via sulfur atom by either Mitsunobu reaction of 2,3,4-tris-O-(trimethylsiliyl)lincomycin or SN2 reaction of 7-O-methanesulfonyl-2,3,4-tri-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc2ac900c1d7ff2aade6371fe8fef76
https://doi.org/10.1038/ja.2015.119
https://doi.org/10.1038/ja.2015.119
Autor:
Kazutaka Ueda, Ko Kumura, Yoko Hirai, Yoshinari Wakiyama, Keiichi Ajito, Eijiro Umemura, Keiko Yamada
Publikováno v:
The Journal of antibiotics. 70(12)
The design and synthesis of lincomycin derivatives modified at the C-6 and C-7 positions are described. A substituent at the C-7 position is a 5-aryl-1,3,4-thiadiazol-2-yl-thio group that generates antibacterial activities against macrolide-resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4331780e93c4622ae7fb1c267ab7123f
https://pubmed.ncbi.nlm.nih.gov/29115289
https://pubmed.ncbi.nlm.nih.gov/29115289
Autor:
Eijiro Umemura, Yoshihiko Kobayashi, Toru Nawa, Akihiro Morinaka, Masakatsu Shibasaki, Toshiaki Miyake, Shoichi Murakami, Yoshiaki Takahashi
Publikováno v:
The Journal of antibiotics. 71(2)
The emergence and spread of bacteria with resistance to antibacterial drugs in recent years is now considered a significant threat to global public health and the world economy.1, 2 In particular, the severe bacterial infections caused by methicillin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48035e2cbba29a902bf3245e6e098dfe
https://pubmed.ncbi.nlm.nih.gov/28655929
https://pubmed.ncbi.nlm.nih.gov/28655929