Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Eiji Warabi"'
Autor:
Ryo Takasaki, Fumihiko Uchida, Shohei Takaoka, Ryota Ishii, Satoshi Fukuzawa, Eiji Warabi, Naomi Ishibashi-Kanno, Kenji Yamagata, Hiroki Bukawa, Toru Yanagawa
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 9, Pp 7630-7641 (2023)
To determine the intracellular behavior of p62, a marker of selective autophagy, in oral potentially malignant disorders (OPMDs). This retrospective study includes 70 patients who underwent biopsy or surgical resection and were definitively diagnosed
Externí odkaz:
https://doaj.org/article/c0e1533cb1ad4318bfce7d306158cfef
Autor:
Kanako Chihara, Kosuke Okada, Fumihiko Uchida, Ikuru Miura, Shoichi Komine, Eiji Warabi, Takako Takayama, Hideo Suzuki, Takashi Matsuzaka, Naomi Ishibashi-Kanno, Kenji Yamagata, Toru Yanagawa, Hiroki Bukawa, Junichi Shoda
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0291880 (2023)
Lipopolysaccharide (LPS) derived from Porphyromonas gingivalis (P.g.), which causes periodontal disease, contributes to the development of non-alcoholic steatohepatitis (NASH). We investigated the role of Nrf2, an antioxidative stress sensor, in macr
Externí odkaz:
https://doaj.org/article/6f0bed8f5a404bd8a3d329b51b60fb10
Autor:
Kaushalya Kulathunga, Arata Wakimoto, Yukiko Hiraishi, Manoj Kumar Yadav, Kyle Gentleman, Eiji Warabi, Tomoki Sakasai, Yoshihiro Miwa, Seiya Mizuno, Satoru Takahashi, Michito Hamada
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Non-alcoholic fatty liver disease (NAFLD) constitutes a metabolic disorder with high worldwide prevalence and increasing incidence. The inflammatory progressive state, non-alcoholic steatohepatitis (NASH), leads to liver fibrosis and carcino
Externí odkaz:
https://doaj.org/article/1e3d06d303874791b7d8c5107ec033d1
Autor:
Ikuru Miura, Kosuke Okada, Akiko Ishii, Eiji Warabi, Takahisa Watahiki, Keii To, Hitoshi Shimano, Shunichi Ariizumi, Junichi Shoda
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Introduction: Obesity is a risk factor for many diseases because it leads to a reduction in skeletal muscle mass and promotes insulin resistance. p62/Sqstm1-knockout mice are a model of metabolic syndrome; show obesity, insulin resistance, and non-al
Externí odkaz:
https://doaj.org/article/3df68411237e4ec8ae7b1dd2f3dfe5d8
Autor:
Masahiro Akiyama, Takamitsu Unoki, Hanako Aoki, Akiyuki Nishimura, Yasuhiro Shinkai, Eiji Warabi, Kazuhiro Nishiyama, Yuka Furumoto, Naohiko Anzai, Takaaki Akaike, Motohiro Nishida, Yoshito Kumagai
Publikováno v:
Redox Biology, Vol 57, Iss , Pp 102514- (2022)
Reactive sulfur species (RSS) play a role in redox homeostasis; however, adaptive cell responses to excessive intracellular RSS are not well understood. Therefore, in this study, we generated transgenic (Tg) mice overexpressing cystathionine gamma-ly
Externí odkaz:
https://doaj.org/article/ef3f1e3c976a479486f613b7e183028e
Autor:
Takuto Hayashi, Takashi Kudo, Ryo Fujita, Shin-ichiro Fujita, Hirona Tsubouchi, Sayaka Fuseya, Riku Suzuki, Michito Hamada, Risa Okada, Masafumi Muratani, Dai Shiba, Takafumi Suzuki, Eiji Warabi, Masayuki Yamamoto, Satoru Takahashi
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Hayashi et al. report on the effect of space flight on muscle mass, fibre size and type, composition and gene signalling of muscle in WT and Nrf2-KO mice. Their results demonstrate a key role of NRF2 in maintaining the slow-type fibres of soleus musc
Externí odkaz:
https://doaj.org/article/54b77403fca14ea68b052687eebe637e
Publikováno v:
Antioxidants, Vol 12, Iss 2, p 274 (2023)
Non-lethal low levels of oxidative stress leads to rapid activation of the transcription factor nuclear factor-E2-related factor 2 (Nrf2), which upregulates the expression of genes important for detoxification, glutathione synthesis, and defense agai
Externí odkaz:
https://doaj.org/article/798a8f306cb24a9684ec95cb0cbf3ddc
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102103- (2021)
Endothelial cells are sensitive to mechanical stress and respond differently to oscillatory flow versus unidirectional flow. This review highlights the mechanisms by which a wide range of unidirectional laminar shear stress induces activation of the
Externí odkaz:
https://doaj.org/article/0ff29c4e5b7842fbb7d9501249949cfb
Autor:
Kazuhiro Kakimi, Hirokazu Matsushita, Masaaki Komatsu, Eiryo Kawakami, Mikako Nishida, Nahoko Yamashita, Taisaku Ogawa, Keita Koseki, Eiji Warabi, Tomoyuki Ohue, Katsuyuki Shiroguchi, Heiichiro Udono
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 9 (2021)
Externí odkaz:
https://doaj.org/article/ea6e95b1875f4efea28894d8d086bffc
Autor:
Takahisa Watahiki, Kosuke Okada, Ikuru Miura, Keii To, Seiya Tanaka, Eiji Warabi, Naomi Kanno, Kenji Yamagata, Naohiro Gotoh, Hideo Suzuki, Shunichi Ariizumi, Kiichiro Tsuchiya, Yukio Nagasaki, Junichi Shoda
Publikováno v:
Antioxidants, Vol 11, Iss 10, p 1939 (2022)
Oxidative stress (OS) contributes to nonalcoholic steatohepatitis (NASH) and hepatocarcinogenesis. We investigated whether antioxidative self-assembling nanoparticles (SMAPoTN) could reduce the development of NASH and hepatocellular carcinoma (HCC) i
Externí odkaz:
https://doaj.org/article/d70c3849098e410a99d7da67a71d86d6