Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Eiji Takahara"'
Autor:
Hideo Kato, Osamu Nagata, Tsuyoshi Yokoi, Taisei Mushiroda, Eiji Takahara, Tetsuya Kamataki, Noritaka Ariyoshi
Publikováno v:
Chemical Research in Toxicology. 14:228-232
The metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was examined in an effort to evaluate the role of flavin-containing monooxygenase (FMO) expressed in the brain of suncus (Suncus murinus) and rats. MPTP was metabolized to generate
Autor:
Hideo Kato, Yuji Iwanaga, Eiji Takahara, Jun Sakaguchi, Miyoji Hanaoka, Takaharu Saito, Nobuhiko Iwasaki
Publikováno v:
Chemical and Pharmaceutical Bulletin. 49:424-436
Novel benzamide derivatives (19-24, 32a-c, 43d-f), each possessing a cycloaminoalkanecarboxylic acid side chain, were synthesized and their gastrointestinal prokinetic and dopamine D2 receptor antagonist activities were evaluated. 4-[(4-Amino-5-chlor
Autor:
Eiji Takahara, Taisei Mushiroda, Kanzo Kimura, Osamu Nagata, Tetsuya Kamataki, Hideo Kato, Noritaka Ariyoshi
Publikováno v:
Biochemical and Biophysical Research Communications. 269:393-396
Northern blot analysis of mRNA prepared from the lung of Suncus murinus (suncus), which was classified as an ancestor of primates, revealed that the expression level of cytochrome P450 2A (CYP2A) mRNA was about 100-fold higher than in the lung from r
Publikováno v:
Toxicology and Applied Pharmacology. 162:44-48
In vitro and in vivo N-oxygenation of trimethylamine (TMA) in the suncus ( Suncus murinus ) was investigated. The N-oxygenation of TMA has been thought to be catalyzed by flavin-containing monooxygenase (FMO). In a previous study, we found that the l
Publikováno v:
Drug Metabolism and Pharmacokinetics. 11:627-633
The absorption, distribution and excretion of 14C-tulobuterol following daily dermal application at 10 mg/kg for 7 days was examined in rats. 1. Blood radioactivity reached a steady state after the 4th dose. After the final dose, blood radioactivity
Publikováno v:
Drug Metabolism and Pharmacokinetics. 11:139-146
Distribution of itopride hydrochloride in the rat gastric muscular layer was determined using radioluminography. To determine the level of radioactivity in the gastric muscular layer, a target organ, after administration of 14C-itopride hydrochloride
Publikováno v:
Drug Metabolism and Pharmacokinetics. 11:634-641
The absorption, distribution and excretion of 14C-tulobuterol or unlabeled tulobuterol following a single application was examined in infant rats. 1. After a single dermal application of a tape containing 14C-tulobuterol at 10 mg/kg, blood radioactiv
Publikováno v:
Drug Metabolism and Pharmacokinetics. 11:614-626
The absorption, distribution, metabolism and excretion of 14C-tulobuterol or unlabeled tulobuterol following a single dermal application was examined in rats. 1. After a single dermal application of a tape containing 14C-tulobuter ol at 10 mg/kg, blo
Publikováno v:
Drug Metabolism and Pharmacokinetics. 9:327-340
The absorption, distribution and excretion of N-[p-[2-(Dimethylamino)ethoxy]benzyl]veratramide hydrochloride (HSR-803) in male rats after repeated oral dosing were studied using 14C-labelled HSR-803. The transfer of radioactivity into the fetus and m
Publikováno v:
Drug Metabolism and Pharmacokinetics. 9:341-350