Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Eiji Sakashita"'
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0299450 (2024)
ObjectivesCompared to conventional disease-modifying antirheumatic drugs (DMARDs), biological DMARDs demonstrate superior efficacy but come with higher costs and increased infection risks. The ability to stop and resume biological DMARD treatment whi
Externí odkaz:
https://doaj.org/article/e567c273f60245628ba0b50b497529da
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Since the advent of biological disease modifying anti-rheumatic drugs (bDMARDs) in the treatment of rheumatoid arthritis (RA), most RA patients receiving such drugs have achieved remission at the expense of cost and infection risk. After bDM
Externí odkaz:
https://doaj.org/article/051cff6178af4e1fa9c08bb352eae101
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Biological disease modifying anti-rheumatic drugs (bDMARDs) show dramatic treatment efficacy in rheumatoid arthritis (RA). Long-term use of bDMARDs, however, has disadvantages such as high costs and infection risk. Therefore, a methodology i
Externí odkaz:
https://doaj.org/article/606f5cad2c804cb4ae173a99ca3d931d
Autor:
Kaoru Tominaga, Eiji Sakashita, Katsumi Kasashima, Kenji Kuroiwa, Yasumitsu Nagao, Naoki Iwamori, Hitoshi Endo
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2113 (2023)
Epigenetic regulation via epigenetic factors in collaboration with tissue-specific transcription factors is curtail for establishing functional organ systems during development. Brain development is tightly regulated by epigenetic factors, which are
Externí odkaz:
https://doaj.org/article/bca3041ac50a4521b705f60baeee8e28
Autor:
Satsuki Miyata, Kaoru Tominaga, Eiji Sakashita, Masashi Urabe, Yoshiyuki Onuki, Akira Gomi, Takashi Yamaguchi, Makiko Mieno, Hiroaki Mizukami, Akihiro Kume, Keiya Ozawa, Eiju Watanabe, Kensuke Kawai, Hitoshi Endo
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Abstract Gliomas with Isocitrate dehydrogenase 1 (IDH1) mutation have alterations in several enzyme activities, resulting in various metabolic changes. The aim of this study was to determine a mechanism for the better prognosis of gliomas with IDH mu
Externí odkaz:
https://doaj.org/article/5f6a67cbdf8045f0aa03230bb5c89474
Autor:
Rintaro Kuroda, Kaoru Tominaga, Katsumi Kasashima, Kenji Kuroiwa, Eiji Sakashita, Hiroko Hayakawa, Tom Kouki, Nobuhiko Ohno, Kensuke Kawai, Hitoshi Endo
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0255355 (2021)
Mitochondrial dysfunction is significantly associated with neurological deficits and age-related neurological diseases. While mitochondria are dynamically regulated and properly maintained during neurogenesis, the manner in which mitochondrial activi
Externí odkaz:
https://doaj.org/article/1c51f28caef64a06b51191bcef97f2be
Autor:
Nobuhiko Ohno, Rintaro Kuroda, Katsumi Kasashima, Hiroko Hayakawa, Kensuke Kawai, Hitoshi Endo, Tom Kouki, Kenji Kuroiwa, Eiji Sakashita, Kaoru Tominaga
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0255355 (2021)
PLoS ONE, Vol 16, Iss 7, p e0255355 (2021)
Mitochondrial dysfunction is significantly associated with neurological deficits and age-related neurological diseases. While mitochondria are dynamically regulated and properly maintained during neurogenesis, the manner in which mitochondrial activi
Autor:
Yoshiyuki Onuki, Satsuki Miyata, Hitoshi Endo, Takashi Yamaguchi, Kensuke Kawai, Eiji Sakashita, Hiroaki Mizukami, Akihiro Kume, Akira Gomi, Masashi Urabe, Eiju Watanabe, Keiya Ozawa, Kaoru Tominaga, Makiko Mieno
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Gliomas with Isocitrate dehydrogenase 1 (IDH1) mutation have alterations in several enzyme activities, resulting in various metabolic changes. The aim of this study was to determine a mechanism for the better prognosis of gliomas with IDH mutation by
Autor:
Hiroaki Mizukami, Akira Gomi, Yoshiyuki Onuki, Takashi Yamaguchi, Eiji Sakashita, Kaoru Tominaga, Satsuki Miyata, Eijyu Watanabe, Masashi Urabe, Hitoshi Endou, Keiya Ozawa, Akihiro Kume, Makiko Mieno, Kensuke Kawai
Publikováno v:
Neuro-oncology Advances
BACKGROUND Gliomas with isocitrate dehydrogenase 1 (IDH1) mutation have alterations in several enzyme activities, resulting in various metabolic changes. The aim of this study was to investigate the mechanism for the better prognosis of gliomas with
Autor:
Tohru Matsuura, Hitoshi Endo, Kenji Kuroiwa, Katsumi Kasashima, Takafumi Mashiko, Yasuyuki Nozaki, Eiji Sakashita, Kaoru Tominaga, Toshiro Hamamoto
Publikováno v:
The Journal of biological chemistry. 291(29)
Cytoplasmic protein aggregates are one of the pathological hallmarks of neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Several RNA-binding proteins have been identified as comp