Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Eiji Okanari"'
1
Identification of a Selective, Non-Prostanoid EP2 Receptor Agonist for the Treatment of Glaucoma: Omidenepag and its Prodrug Omidenepag Isopropyl
Autor: Eiji Okanari, Tomoko Kirihara, Kenji Yoneda, Ryo Iwamura, Naveed K Shams, Noriko Odani-Kawabata, Masayuki Tanaka
Publikováno v: Journal of medicinal chemistry. 61(15)
EP2 receptor agonists are expected to be effective ocular hypotensive agents; however, it has been suggested that agonism to other EP receptor subtypes may lead to undesirable effects. Through medicinal chemistry efforts, we identified a scaffold bea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f458e261a47f1077ac8e3431a66d45
https://pubmed.ncbi.nlm.nih.gov/29995405
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2
Therapeutic efficacy of a novel LPA1 receptor antagonist, UD-009, in a bleomycin-induced pulmonary fibrosis model
Autor: Yuuko Shinohara, Eiji Okanari, Noriaki Iwase, Kenji Nishikawa, Hiroshi Nishida, Hironobu Matsunaga, Shigeru Ushiyama
Publikováno v: 3.3 Mechanisms of Lung Injury and Repair.
Background: Lysophosphatidic acid (LPA) is known as a fibrotic lipid mediator. Mice lacking LPA1 receptor or treated with a LPA1 antagonist are protected from bleomycin (BLM)-induced pulmonary fibrosis. However, the therapeutic efficacy has not yet b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b30a6a76682585aca3279e8c7076b49
https://doi.org/10.1183/13993003.congress-2016.pa4032
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3
Heme oxygenase activity and cytochrome P‐450 content associated with induced metallothionein in the liver of rats treated with various metals
Autor: Koji Arizono, Toshihiko Ariyoshi, Eiji Okanari, Kiyoshi Ueno
Publikováno v: Journal of Environmental Science and Health . Part A: Environmental Science and Engineering and Toxicology. 26:941-951
The relationship between heme oxygenase (HO) activity and metallothionein (MT) concentration in rat liver was investigated. The responses to treatments with metals of the ?‐series metals that can bind to MT in vivo (e.g., cadmium, zinc and copper)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70c56394ac37c51f178983c5d310decd
https://doi.org/10.1080/10934529109375676
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5
Catalytic and physical properties of Ca2+-doped MgO
Autor: Ken Ichiro Kobayashi, Yoshiro Morita, Eiji Okanari, Masahiko Matsukata, Eiichi Kikuchi
Publikováno v: Journal of The Japan Petroleum Institute. 32:97-109
Ca2+ ions loaded on MgO surface markedly promoted catalytic activities of MgO for isomerization of 1-butene, hydrocarbon gasification with CO2 or O2, and the reverse water-gas shift reaction, although MgO itself was almost inactive after treatment at
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::981c7bc0b0ac8d382855ac0c1903cbcc
https://doi.org/10.1627/jpi1958.32.97
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6
Effects of Metallothionein Binding Capacity for Various Metals on Heme Oxygenase Activity
Autor: Koji Arizono, Kiyoshi Ueno, Eiji Okanari, Toshihiko Ariyoshi
Publikováno v: Trace Elements in Man and Animals 6 ISBN: 9781461280507
It is well known that metallothionein (MT), which is involved in protection from metal toxicity and homeostasis of essential metals, is induced by various metals (1). In general, these metals are divided into two groups: those that bind to MT in vivo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::589c561795159638c623879272223595
https://doi.org/10.1007/978-1-4613-0723-5_251
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