Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Eiji Ochiai"'
Autor:
Kazuhito Tsuruta, Eiji Ochiai, Yukiko Suzuki, Akihiko Okayama, Koichi Nakao, Akiko Sugimoto, Takekazu Ohi, Kosho Iwao, Shogo Yazawa
Publikováno v:
Journal of the Neurological Sciences. 404:112-114
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9ebd0f65e2fabf4f6bd6afdd8f30f44
https://doi.org/10.1016/j.jns.2019.07.030
https://doi.org/10.1016/j.jns.2019.07.030
Autor:
Atsushi Kittaka, Akiko Takeuchi, Eiji Ochiai, Daisuke Sawada, Midori Kamimura-Takimoto, Shinji Kakuda, Fumihiro Kawagoe
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 173:79-82
According to the binding mode of 14-epi-1α,25-dihydroxy-19-nortachysterol in the ligand binding domain of human vitamin D receptor (hVDR), i.e., 5,6- and 7,8-s-trans configuration that was shown by X-ray co-crystallographic analysis, 7,8-cis-locked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::967eb33ed901624b2860f5ab513c03ee
https://doi.org/10.1016/j.jsbmb.2016.09.007
https://doi.org/10.1016/j.jsbmb.2016.09.007
Autor:
Kyohei Horie, Takashi Misawa, Midori Takimoto-Kamimura, Genichiro Tsuji, Eiji Ochiai, Shinji Kakuda, Takeo Takahashi, Kenichiro Takagi, Masaaki Kurihara, Yosuke Demizu
Publikováno v:
Bioorganicmedicinal chemistry. 26(23-24)
Non-secosteroidal VDR ligands without any assymmetric carbon were designed and synthesized based on the structure of the previously reported non-secosteroidal VDR agonist LG190178. The VDR-agonistic activity of all synthesized compounds was evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eee8314c042eed9a4a6e212974c71d4
https://pubmed.ncbi.nlm.nih.gov/30446437
https://pubmed.ncbi.nlm.nih.gov/30446437
Autor:
Akiko Sugimoto, Koichi Nakao, Shogo Yazawa, Masao Matsuhashi, Eiji Ochiai, Yukiko Suzuki, Katsuya Sakai, Kazuhito Tsuruta
Publikováno v:
Epileptic disorders : international epilepsy journal with videotape. 20(2)
We report a 33-year-old Japanese man who suffered from repetitive generalized tonic-clonic seizures which were medically intractable. Neurosyphilis was serologically diagnosed in blood and cerebrospinal fluid, and penicillin G (PcG) was consequently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d865e1348cbe89ebc6d6f7bf85a0f0f
https://pubmed.ncbi.nlm.nih.gov/30530406
https://pubmed.ncbi.nlm.nih.gov/30530406
Autor:
Daisuke, Sawada, Eiji, Ochiai, Akiko, Takeuchi, Shinji, Kakuda, Midori, Kamimura-Takimoto, Fumihiro, Kawagoe, Atsushi, Kittaka
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 173
According to the binding mode of 14-epi-1α,25-dihydroxy-19-nortachysterol in the ligand binding domain of human vitamin D receptor (hVDR), i.e., 5,6- and 7,8-s-trans configuration that was shown by X-ray co-crystallographic analysis, 7,8-cis-locked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e754f057507ab56a75274b368ee67c6a
https://pubmed.ncbi.nlm.nih.gov/27629592
https://pubmed.ncbi.nlm.nih.gov/27629592
Autor:
Yosuke Demizu, Takeo Takahashi, Kenichiro Takagi, Fumiya Kaneko, Masaaki Kurihara, Midori Takimoto-Kamimura, Haruhiro Okuda, Shinji Kakuda, Yukiko Sato, Kyohei Horie, Eiji Ochiai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6104-6107
We designed and synthesized nonsecosteroidal vitamin D receptor (VDR) ligands that formed H-bonds with six amino acid residues (Tyr143, Ser233, Arg270, Ser274, His301 and His393) of the VDR ligand-binding domain. The ligand YR335 exhibited potent tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad27bdb572ed18a8d8519a4c4a96c66
https://doi.org/10.1016/j.bmcl.2011.08.047
https://doi.org/10.1016/j.bmcl.2011.08.047
Autor:
Masashi Takano, Hiroshi Saito, Seiichi Ishizuka, Nozomi Saito, Eiji Ochiai, Atsushi Kittaka, Shinji Kakuda, Kanako Shindo, Kyohei Horie, Midori Takimoto-Kamimura, Ken Ichiro Takagi, Go Kumagai, Daisuke Sawada, Kazuya Takenouchi
Publikováno v:
Organic Letters. 13:2852-2855
C15-Substituted 1α,25-dihydroxyvitamin D(3) analogs were synthesized for the first time to investigate the effects of the modified CD-ring on biological activity concerning the agonistic positioning of helix-3 and helix-12 of the vitamin D receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f988d030c8cebf6797d3750a5c8e6a
https://doi.org/10.1021/ol200828s
https://doi.org/10.1021/ol200828s
Autor:
Hiroshi Saito, Eiji Ochiai, Seiichi Ishizuka, Nozomi Saito, Atsushi Kittaka, Ken Ichiro Takagi, Yuya Tsukuda, Tomoyuki Katayama, Daisuke Sawada, Kazuya Takenouchi
Publikováno v:
Tetrahedron. 66:5407-5423
2α- and 2β-Substituted analogs of 14-epi-previtamin D3 were synthesized and isolated after thermal isomerization of 14-epi-vitamin D3 triene at 80 °C. The VDR binding affinity and transactivation activity of osteocalcin promoter in HOS cells were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a93b67ab2fa7092ddc38c6b0cfc60cfc
https://doi.org/10.1016/j.tet.2010.05.028
https://doi.org/10.1016/j.tet.2010.05.028
Autor:
Eiji Ochiai, Seiichi Ishizuka, Nozomi Saito, Daisuke Sawada, Atsushi Kittaka, Kazuya Takenouchi, Tomoyuki Katayama, Masashi Takano, Yuya Tsukuda, Ken Ichiro Takagi, Hiroshi Saito
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5397-5400
We synthesized and isolated 2 alpha-substituted analogs of 14-epi-previtamin D3 after thermal isomerization at 80 degrees C for the first time. The VDR binding affinity and transactivation activity of osteocalcin promoter in HOS cells were evaluated,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9b0e62d5ff848ad8b19ec2a0f77d60
https://doi.org/10.1016/j.bmcl.2009.07.112
https://doi.org/10.1016/j.bmcl.2009.07.112
Autor:
Miki Matsuo, Asami Hasegawa, Masashi Takano, Hiroshi Saito, Shinji Kakuda, Kenichiro Takagi, Eiji Ochiai, Kyohei Horie, Midori Takimoto-Kamimura, Kazuya Takenouchi, et al. et al.
Publikováno v:
ChemInform. 46
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7ecf9954ce7da3ce36bfe10a3d6da61
https://doi.org/10.1002/chin.201509332
https://doi.org/10.1002/chin.201509332