Výsledky vyhledávání - "Eiji Nishiwaki"

Akademický článek

Telmisartan inhibits cell proliferation by blocking nuclear translocation of ProHB-EGF C-terminal fragment in colon cancer cells.

Autor: Keiji Ozeki, Satoshi Tanida, Chie Morimoto, Yoshimasa Inoue, Tsutomu Mizoshita, Hironobu Tsukamoto, Takaya Shimura, Hiromi Kataoka, Takeshi Kamiya, Eiji Nishiwaki, Hiroshi Ishiguro, Shigeki Higashiyama, Takashi Joh

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e56770 (2013)

BACKGROUND AIMS: Current treatment target toward advanced colorectal cancers is mainly focused on the epidermal growth factor receptor (EGFR) signaling, but its additive effects with chemotherapy are still limited. A disintegrin and metalloproteinase

Externí odkaz: https://doaj.org/article/ba2a0cad1d9b4d3587c2fc7c2d83e23a

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Activity-based kinase profiling of approved tyrosine kinase inhibitors

Autor: Kensaku Akita, Hiroshi Ohmoto, Eiji Nishiwaki, Koichi Yokota, Masaki Gouda, Yugo Narumi, Yasuyuki Kirii, Daisuke Kitagawa

Publikováno v: Genes to Cells. 18:110-122

The specificities of nine approved tyrosine kinase inhibitors (imatinib, dasatinib, nilotinib, gefitinib, erlotinib, lapatinib, sorafenib, sunitinib, and pazopanib) were determined by activity-based kinase profiling using a large panel of human recom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f853d18fadece6055167ba1af93b6136
https://doi.org/10.1111/gtc.12022

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BAZF, a novel component of cullin3-based E3 ligase complex, mediates VEGFR and Notch cross-signaling in angiogenesis

Autor: Tomohisa Sakaue, Yaeta Endo, Hidetaka Ohnuki, Shinji Fukuda, Eiji Nishiwaki, Hironao Nakayama, Masahiko Hatano, Hirofumi Inoue, Masato Nose, Takeshi Tokuhisa, Shigeki Higashiyama, Nobuaki Takemori, Daisuke Miwa

Publikováno v: Blood. 119:2688-2698

Angiogenic homeostasis is maintained by a balance between vascular endothelial growth factor (VEGF) and Notch signaling in endothelial cells (ECs). We screened for molecules that might mediate the coupling of VEGF signal transduction with down-regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90ee2e870eb0dd5de0fdeaffc27c87a3
https://doi.org/10.1182/blood-2011-03-345306

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PACSIN3 Binds ADAM12/Meltrin α and Up-regulates Ectodomain Shedding of Heparin-binding Epidermal Growth Factor-like Growth Factor

Autor: Hiroshi Ishiguro, Eiji Nishiwaki, Daisuke Nanba, Seiji Mori, Motonari Tanaka, Shigeki Higashiyama, Nariaki Matsuura

Publikováno v: Journal of Biological Chemistry. 278:46029-46034

A disintegrin and metalloprotease 12 (ADAM12/meltrin alpha) is a key enzyme implicated in the ectodomain shedding of membrane-anchored heparin-binding epidermal growth factor (EGF)-like growth factor (proHB-EGF)-dependent epidermal growth factor rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3162d2671b522d3f66d3ab33de8a7385
https://doi.org/10.1074/jbc.m306393200

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Bone Malformations in Interleukin-18 Transgenic Mice

Autor: Koichi Yokota, Hisamichi Aizawa, Michihisa Zenmyo, Kohichiro Yoshino, Akemi Kuzuhara, Yusuke Kawase, Tomoaki Hoshino, Yu Maeda, Masanori Nakamura, Koji Hiraoka, Eiji Nishiwaki

Publikováno v: Journal of Bone and Mineral Research. 18:975-983

The in vivo effects of IL-18 on bone metabolism were investigated by histopathology in IL-18 transgenic mice. Deformed cortical bone and decreased turnover rate of lumbar trabecular bone are consistent with increased expression of IFN-gamma and IL-18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d37c793a098677f4881bdb303b9174
https://doi.org/10.1359/jbmr.2003.18.6.975

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New Type of Metalloproteinase Inhibitor: Design and Synthesis of New Phosphonamide-Based Hydroxamic Acids

Autor: Yasuko Ito, Minoru Yamamoto, Masaaki Sawa, Yu Maeda, Tomomi Inoue, Etsuko Ishibushi, Ryoichi Hirayama, Eiji Nishiwaki, Yoshimasa Inoue, Kohichiro Yoshino, Yasuyuki Kirii, Kiriko Kurokawa, Tomohiro Miyasaka, Hirosato Kondo, Takao Kiyoi, Hiroshi Kumihara, Hiroshi Ohmoto

Publikováno v: Journal of Medicinal Chemistry. 45:919-929

A series of phosphonamide-based hydroxamate derivatives were synthesized, and the inhibitory activities were evaluated against various metalloproteinases in order to clarify its selectivity profile. Among the four diastereomeric isomers resulting fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79cda93ba742f3aff92e244d17d126da
https://doi.org/10.1021/jm0103211

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Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity

Autor: Eiji Nishiwaki, Kohichiro Yoshino, Hirohide Sawada, Tsuyoshi Yoshinaka, Hiroshi Ishiguro, Katherine Smith, Kouji Yamada, Kazuhiro Nishii, Shigeki Higashiyama

Publikováno v: Gene. 282:227-236

The ADAM family of membrane-anchored proteins has a unique domain structure, with each containing a disintegrin and metalloprotease (ADAM) domain. We have isolated mouse and human cDNAs encoding a novel member of the ADAM family. The mouse and human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6c66fb9e9b1e9a274e4c687ccc633d
https://doi.org/10.1016/s0378-1119(01)00818-6

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Regulation of CDK7–Carboxyl-Terminal Domain Kinase Activity by the Tumor Suppressor p16INK4A Contributes to Cell Cycle Regulation

Autor: Eiji Nishiwaki, Hiroaki Serizawa, James Koh, Masahide Kashiwagi, Shiro Miyazaki, Susanna Harju, Saralinda L. Turner

Publikováno v: Molecular and Cellular Biology. 20:7726-7734

The eukaryotic cell cycle is regulated by cyclin-dependent kinases (CDKs). CDK4 and CDK6, which are activated by D-type cyclins during the G(1) phase of the cell cycle, are thought to be responsible for phosphorylation of the retinoblastoma gene prod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd8c1e060a2a676587881f18f8e4d46
https://doi.org/10.1128/mcb.20.20.7726-7734.2000

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Telmisartan Inhibits Cell Proliferation by Blocking Nuclear Translocation of ProHB-EGF C-Terminal Fragment in Colon Cancer Cells

Autor: Hiromi Kataoka, Hironobu Tsukamoto, Takashi Joh, Hiroshi Ishiguro, Eiji Nishiwaki, Tsutomu Mizoshita, Satoshi Tanida, Chie Morimoto, Keiji Ozeki, Takeshi Kamiya, Yoshimasa Inoue, Takaya Shimura, Shigeki Higashiyama

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 2, p e56770 (2013)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ba29871eca06358efd06c7c64b7153
http://europepmc.org/articles/PMC3579940

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Synthesis of a sulfulr-containing 10-membered enediyne model compound related to the esperamicin/calicheamicin/dynemicin agylcones

Autor: Eiji Nishiwaki, Masaru Kido, Kozo Shishido, Masayuki Shibuya, Yasuhiro Sakai

Publikováno v: Tetrahedron Letters. 32:4363-4366

Synthesis of the 10-membered heterocyclic enediyne 4 and its conversion to the benzenoid adduct 10 via the Bergman reaction are described.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ced2e8c8bcabf6b8b0cf8aced8ac94a
https://doi.org/10.1016/s0040-4039(00)92171-3

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