Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Eiji Munetomo"'
Autor:
Yasunobu Ushiki, Kenichi Kawabe, Kumiko Yamamoto-Okada, Fumito Uneuchi, Yuta Asanuma, Chitose Yamaguchi, Hiroshi Ohta, Tsuyoshi Shibata, Tomohiro Abe, Lisa Okumura-Kitajima, Yuki Kosai, Mayumi Endo, Katsumasa Otake, Eiji Munetomo, Teisuke Takahashi, Hiroyuki Kakinuma
Publikováno v:
Bioorganicmedicinal chemistry letters. 59
Intestinal sodium-dependent phosphate transport protein 2b (SLC34A2, NaPi2b) inhibitors are expected to be potential new candidates for anti-hyperphosphatemia drugs. However, a risk of on-target side effects based on the inhibition of NaPi2b in the l
Autor:
Yasunobu, Ushiki, Kenichi, Kawabe, Kumiko, Yamamoto-Okada, Fumito, Uneuchi, Yuta, Asanuma, Chitose, Yamaguchi, Hiroshi, Ohta, Tsuyoshi, Shibata, Tomohiro, Abe, Lisa, Okumura-Kitajima, Yuki, Kosai, Mayumi, Endo, Katsumasa, Otake, Eiji, Munetomo, Teisuke, Takahashi, Hiroyuki, Kakinuma
Publikováno v:
Bioorganic & Medicinal Chemistry. 66:116783
Intestinal sodium-dependent phosphate transport protein 2b (SLC34A2, NaPi2b) inhibitors are expected to be potential new candidates for anti-hyperphosphatemia drugs. However, a risk of on-target side effects based on the inhibition of NaPi2b in the l
Autor:
Yasunobu Ushiki, Kenichi Kawabe, Kumiko Yamamoto-Okada, Fumito Uneuchi, Yuta Asanuma, Chitose Yamaguchi, Hiroshi Ohta, Tsuyoshi Shibata, Tomohiro Abe, Lisa Okumura-Kitajima, Yuki Kosai, Mayumi Endo, Katsumasa Otake, Eiji Munetomo, Teisuke Takahashi, Hiroyuki Kakinuma
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 65:128700
We previously reported thiophene derivatives as gut-selective (minimally systemic) and potent sodium-dependent phosphate transport protein 2b (SLC34A2, NaPi2b) inhibitors. However, these derivatives did not suppress phosphate absorption form the inte
Autor:
Aiko Masuko, Yoshihisa Shirasaki, Kanako Iwakiri, Nagaaki Sato, Akiko Nozoe, Tsuyoshi Busujima, Kiyokazu Kitano, Eiji Munetomo, Hiroaki Tanaka, Fusayo Io, Masako Saito, Shunsuke Kamigaso, Kato Koji
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 64:228-238
We previously reported 2-[2-(4-tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide 2 as on orally available monoacylglycerol acyltransferase 2 (MGAT2) inhibitor which exhibited an in vivo efficacy at an oral dose o
Autor:
Yoshihisa Shirasaki, Eiji Munetomo, Naoto Osaki, Kiyokazu Kitano, Hiroaki Tanaka, Nagaaki Sato, Toshiya Minagawa, Tsuyoshi Busujima, Masako Saito, Koji Yoshida
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:5922-5931
MGAT2 (monoacylglycerol acyltransferase 2) is expected to be an attractive target for the drug treatment of obesity, diabetes, and other disease. We describe our exploration and structure-activity relationship (SAR) study of 2,3-dihydro-1H-isoindole-
Autor:
Tsuyoshi, Busujima, Hiroaki, Tanaka, Kanako, Iwakiri, Yoshihisa, Shirasaki, Eiji, Munetomo, Masako, Saito, Aiko, Masuko, Kiyokazu, Kitano, Fusayo, Io, Koji, Kato, Shunsuke, Kamigaso, Akiko, Nozoe, Nagaaki, Sato
Publikováno v:
Chemicalpharmaceutical bulletin. 64(3)
We previously reported 2-[2-(4-tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide 2 as on orally available monoacylglycerol acyltransferase 2 (MGAT2) inhibitor which exhibited an in vivo efficacy at an oral dose o
Autor:
Gerald W. Hart, Lance Wells, Hiroshi Hirano, Yoshihiro Akimoto, Shinya Nagamatsu, Keith Vosseller, Hayato Kawakami, Koji Yamamoto, Mica Ohara-Imaizumi, Chiyono Nishiwaki, Eiji Munetomo
Publikováno v:
Glycobiology. 17:127-140
Many nuclear and cytoplasmic proteins are O-glycosylated on serine or threonine residues with the monosaccharide beta-N-acetylglucosamine, which is then termed O-linked N-acetylglucosamine (O-GlcNAc). It has been shown that abnormal O-GlcNAc modifica
Autor:
Keith Vosseller, Hiroshi Hirano, Lance Wells, Eiji Munetomo, Hayato Kawakami, Koji Yamamoto, Gerald W. Hart, Yoshihiro Akimoto
Publikováno v:
ACTA HISTOCHEMICA ET CYTOCHEMICA. 38:131-142
We aimed to examine the changes of O-GlcNAc modification of proteins in diabetes, especially in the pathogenesis of diabetic complications. The expression of O-GlcNAc-modified proteins and O-GlcNAc transferase was examined by Western blot analysis an
Autor:
Tadayasu Okazaki, Takayuki Seki, Yoji Kawamura, Tsutomu Ando, Chu Yiwen, Yuichi Terui, Shigeru Murakami, Koji Yamamoto, Haruaki Yamamoto, Li Jun-ying, Saeko Uchida, Akira Kawashima, Eiji Munetomo, Yasumitsu Tomishima
Publikováno v:
Tetrahedron Letters. 44:5427-5430
In the course of our screening program to identify inhibitors of HSP47 gene expression, we obtained a novel aromatic substance from Streptomyces sp. named Xantholipin. Its structure was determined based on physicochemical data of Xantholipin and its
Autor:
Takatoshi Nagate, Yoshihisa Toda, Yukiko Kondo, Takayuki Seki, Yoko Furukawa, Mototaka Matsuyama, Nobuko Hosokawa, Takanobu Sakurai, Shigeru Murakami, Kazuhiro Nagata, Eiji Munetomo
Publikováno v:
Atherosclerosis. 157:361-368
Heat shock protein (HSP) 47, a collagen-specific molecular chaperone, is thought to be essential for the proper processing and secretion of procollagen molecules. We investigated the time course and localization of HSP47 and collagen expression after