Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Eiji Iwao"'
Autor:
Toshiya Inaba, Hirotaka Matsui, Mayu Onishi, Shoichi Takahashi, Eiji Iwao, C. Nelson Hayes, Ichimaro Yamada, Tomohiko Kono, Naohiro Kamiya, Akinori Kanai, Kazuaki Chayama, Michio Imamura, Katsutoshi Yoshizato, Hidenori Ochi, Nobuhiko Hiraga, Hiromi Abe, Chise Tateno, Masataka Tsuge, Shinji Tanaka
Publikováno v:
Hepatology. 54:781-788
Telaprevir is a potent inhibitor of hepatitis C virus (HCV) NS3-4A protease. However, the emergence of drug-resistant strains during therapy is a serious problem, and the susceptibility of resistant strains to interferon (IFN), as well as the details
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a7a809085bff011ffd9d7fda7db83ac
https://doi.org/10.1002/hep.24460
https://doi.org/10.1002/hep.24460
Autor:
Yuuki Miyatake, Eiji Iwao, Yoshiyasu Kawabata, Kazuyoshi Ikuta, Christine MacLean, Takeru Urayama, Shinji Hattori, Elaine Wilson, Masanori Morita, Masahiro Ohtani, Ayako Nanjo, Hiroyuki Tanaka, Mikihiro Yunoki, Yuji Ohkubo
Publikováno v:
Biologicals. 36:27-36
Manufacturing processes used in the production of biopharmaceutical or biological products should be evaluated for their ability to remove potential contaminants, including TSE agents. In the present study, we have evaluated scrapie prion protein (Pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3634871ca9815161e41f99dc091d2761
https://doi.org/10.1016/j.biologicals.2007.04.005
https://doi.org/10.1016/j.biologicals.2007.04.005
Autor:
Hidenori Ochi, Eiji Iwao, Toshiro Maekawa, Michio Imamura, Hiromi Abe, Chise Tateno, Chiemi Noguchi, Yoshifumi Fujimoto, Katsutoshi Yoshizato, Hiromi Yatsuji, Fumitaka Suzuki, Nami Mori, Kazuaki Chayama, Masataka Tsuge, Nobuhiko Hiraga, Shoichi Takahashi, Hiromitsu Kumada
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:3867-3874
Lamivudine is a major drug approved for treatment of chronic hepatitis B virus (HBV) infection. Emergence of drug-resistant mutants with amino acid substitutions in the YMDD motif is a well-documented problem during long-term lamivudine therapy. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72f0a36075417d542a008abf9b2172e
https://doi.org/10.1128/aac.00239-06
https://doi.org/10.1128/aac.00239-06
Autor:
Hiromi Abe, C. Nelson Hayes, Ichimaro Yamada, Eiji Iwao, Tomohiko Kono, Naohiro Kamiya, Kazuaki Chayama, Hidenori Ochi, Tomokazu Kawaoka, Masataka Tsuge, Daizaburo Hirata, Nobuhiko Hiraga, Chise Tateno, Shoichi Takahashi, Fukiko Mitsui, Eiji Ohara, Mayu Onishi, Katsutoshi Yoshizato, Shinji Tanaka, Michio Imamura
Publikováno v:
Journal of hepatology. 54(5)
Background & Aims The current treatment regimen for chronic hepatitis C virus (HCV) infection is peg-interferon plus ribavirin combination therapy. The majority of developing therapeutic strategies also contain peg-interferon with or without ribaviri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936f328e2a4bc07a337f8671f7ff94c7
https://pubmed.ncbi.nlm.nih.gov/21145816
https://pubmed.ncbi.nlm.nih.gov/21145816
Establishment of an infectious genotype 1b hepatitis C virus clone in human hepatocyte chimeric mice
Autor:
Hidenori Ochi, Shoichi Takahashi, Yoshiharu Matsuura, Toshiro Maekawa, Kazuaki Chayama, Keiko Arataki, Nami Mori, Yoshifumi Fujimoto, Eiji Iwao, Hiromi Abe, Michio Imamura, Daiki Miki, Chiemi Noguchi, Takashi Kimura, Masataka Tsuge, Takaji Wakita, Tsuyoshi Hatakeyama, Katsutoshi Yoshizato, Nobuhiko Hiraga, Chise Tateno, Toru Okamoto
Publikováno v:
The Journal of general virology. 89(Pt 9)
The establishment of clonal infection of hepatitis C virus (HCV) in a small-animal model is important for the analysis of HCV virology. A previous study developed models of molecularly cloned genotype 1a and 2a HCV infection using human hepatocyte-tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::987d8e38888e15da79dbd677bd804e85
https://pubmed.ncbi.nlm.nih.gov/18753219
https://pubmed.ncbi.nlm.nih.gov/18753219
Autor:
Eiji Iwao, Hidenori Ochi, Hiromi Abe, Toshiro Maekawa, Michio Imamura, Chiemi Noguchi, Masao Honda, Yoshio Sakai, Masataka Tsuge, Yoshifumi Fujimoto, Takaji Wakita, Kazuaki Chayama, Akihito Sakai, Chise Tateno, Shuichi Kaneko, Shoichi Takahashi, Nobuhiko Hiraga, Katsutoshi Yoshizato
Publikováno v:
FEBS letters. 581(10)
We developed a reverse genetics system of hepatitis C virus (HCV) genotypes 1a and 2a using infectious clones and human hepatocyte chimeric mice. We inoculated cell culture-produced genotype 2a (JFH-1) HCV intravenously. We also injected genotype 1a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b01e3823d7fb2029e21da3a5d1fbdb9
https://pubmed.ncbi.nlm.nih.gov/17466983
https://pubmed.ncbi.nlm.nih.gov/17466983
Autor:
Yoshifumi Fujimoto, Masataka Tsuge, Nobuhiko Hiraga, Hidenori Ochi, Hiromi Oga, Shoichi Takahashi, Katsutoshi Yoshizato, Kazuaki Chayama, Eiji Iwao, Michio Imamura, Chise Tateno, Hideki Takaishi, Chiemi Noguchi
Publikováno v:
Hepatology (Baltimore, Md.). 42(5)
Studies of hepatitis B virus (HBV) mutants have been hampered by the lack of a small animal model with long-term infection of cloned HBV. Using a mouse model in which liver cells were highly replaced with human hepatocytes that survived over a long t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997252db678702c6a3f7f30e451b4fef
https://pubmed.ncbi.nlm.nih.gov/16250045
https://pubmed.ncbi.nlm.nih.gov/16250045
Autor:
Shiro Takagi, Hidenobu Kusuhara, Yoshifumi Ikeda, Eiji Iwao, Yoshito Yokoyama, Fumihiro Hirayama
Publikováno v:
Journal of Gastroenterology. 31:755-757
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a834cd7e8f800b2cb8f56ddfc00a9a
https://doi.org/10.1007/bf02347631
https://doi.org/10.1007/bf02347631
Publikováno v:
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 9(2)
Y-904 is a new fluoroquinolone with a broad antimicrobial spectrum. In particular, it has anti- Helicobacter pylori activity superior to that of existing fluoroquinolones. In the present study it was examined for its in vitro antibacterial activity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b94c1b21a1b85ca645e17e86d5ff46
https://pubmed.ncbi.nlm.nih.gov/12825117
https://pubmed.ncbi.nlm.nih.gov/12825117
Publikováno v:
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 10(2)
Y-754, a novel benzimidazole compound, was investigated for in vitro and in vivo antibacterial activity. Unlike amoxicillin, clarithromycin, and metronidazole, the compound had no activity against common aerobic and anaerobic bacteria other than Heli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d0b72b2dac9814579ffb85d6755e60
https://pubmed.ncbi.nlm.nih.gov/15160301
https://pubmed.ncbi.nlm.nih.gov/15160301