Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Eiji, Shigetomi"'
Autor:
Eiji Shigetomi, Hideaki Suzuki, Yukiho J. Hirayama, Fumikazu Sano, Yuki Nagai, Kohei Yoshihara, Keisuke Koga, Toru Tateoka, Hideyuki Yoshioka, Youichi Shinozaki, Hiroyuki Kinouchi, Kenji F. Tanaka, Haruhiko Bito, Makoto Tsuda, Schuichi Koizumi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Reactive astrocytes play a pivotal role in the pathogenesis of neurological diseases; however, their functional phenotype and the downstream molecules by which they modify disease pathogenesis remain unclear. Here, we genetically increase P2
Externí odkaz:
https://doaj.org/article/2557cf6cc7f6489ba3fc0d968dc92110
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2024)
Extracellular ATP and adenosine are neuromodulators that regulate numerous neuronal functions in the brain. Neuronal activity and brain insults such as ischemic and traumatic injury upregulate these neuromodulators, which exert their effects by activ
Externí odkaz:
https://doaj.org/article/510ce85823cb4570a6016bb9be614d22
Autor:
Tatsuya Ihara, Hiroshi Shimura, Sachiko Tsuchiya, Mie Kanda, Satoru Kira, Norifumi Sawada, Masayuki Takeda, Takahiko Mitsui, Eiji Shigetomi, Yoichi Shinozaki, Schuichi Koizumi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Dysregulation of circadian rhythm can cause nocturia. Levels of fatty acid metabolites, such as palmitoylethanolamide (PEA), 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE), and 4-hydroxy-5E,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid (4-HDoHE),
Externí odkaz:
https://doaj.org/article/a2268da3549b4b64bae0bf8a0f7daa57
Autor:
Fumikazu Sano, Eiji Shigetomi, Youichi Shinozaki, Haruka Tsuzukiyama, Kozo Saito, Katsuhiko Mikoshiba, Hiroshi Horiuchi, Dennis Lawrence Cheung, Junichi Nabekura, Kanji Sugita, Masao Aihara, Schuichi Koizumi
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
Extensive activation of glial cells during a latent period has been well documented in various animal models of epilepsy. However, it remains unclear whether activated glial cells contribute to epileptogenesis, i.e., the chronically persistent proces
Externí odkaz:
https://doaj.org/article/a915495c6e1f433aba8681799e7b07bc
Autor:
Manao Kinoshita, Yuri Hirayama, Kayoko Fujishita, Keisuke Shibata, Youichi Shinozaki, Eiji Shigetomi, Akiko Takeda, Ha Pham Ngoc Le, Hideaki Hayashi, Miki Hiasa, Yoshinori Moriyama, Kazuhiro Ikenaka, Kenji F. Tanaka, Schuichi Koizumi
Publikováno v:
EBioMedicine, Vol 32, Iss , Pp 72-83 (2018)
Although psychotropic drugs act on neurons and glial cells, how glia respond, and whether glial responses are involved in therapeutic effects are poorly understood. Here, we show that fluoxetine (FLX), an anti-depressant, mediates its anti-depressive
Externí odkaz:
https://doaj.org/article/0994b8524db94945898522171ad5a080
Autor:
Yosuke M. Morizawa, Mami Matsumoto, Yuka Nakashima, Narumi Endo, Tomomi Aida, Hiroshi Ishikane, Kaoru Beppu, Satoru Moritoh, Hitoshi Inada, Noriko Osumi, Eiji Shigetomi, Schuichi Koizumi, Guang Yang, Hirokazu Hirai, Kohichi Tanaka, Kenji F. Tanaka, Nobuhiko Ohno, Yugo Fukazawa, Ko Matsui
Publikováno v:
Nature Neuroscience. 25:1458-1469
Synaptic pruning is a fundamental process of neuronal circuit refinement in learning and memory. Accumulating evidence suggests that glia participates in sculpting the neuronal circuits through synapse engulfment. However, whether glial involvement i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350e14d4d2dda9687414ccbacc3543e5
https://doi.org/10.1038/s41593-022-01184-5
https://doi.org/10.1038/s41593-022-01184-5
Autor:
Yosuke M. Morizawa, Yuri Hirayama, Nobuhiko Ohno, Shinsuke Shibata, Eiji Shigetomi, Yang Sui, Junichi Nabekura, Koichi Sato, Fumikazu Okajima, Hirohide Takebayashi, Hideyuki Okano, Schuichi Koizumi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Astrocytic phagocytosis has been shown to play a role in synaptic pruning during development, but whether adult astrocytes possess phagocytic ability is unclear. Here the authors show that following brain ischemia, reactive astrocytes become phagocyt
Externí odkaz:
https://doaj.org/article/ae5888d09dbf4fd4aac1a32a1f9621b4
Autor:
Youichi Shinozaki, Keisuke Shibata, Keitaro Yoshida, Eiji Shigetomi, Christian Gachet, Kazuhiro Ikenaka, Kenji F. Tanaka, Schuichi Koizumi
Publikováno v:
Cell Reports, Vol 19, Iss 6, Pp 1151-1164 (2017)
Microglia and astrocytes become reactive following traumatic brain injury (TBI). However, the coordination of this reactivity and its relation to pathophysiology are unclear. Here, we show that microglia transform astrocytes into a neuroprotective ph
Externí odkaz:
https://doaj.org/article/7887800b970d4006874b04452b89b1d0
Autor:
Satoru Kira, Mitsuharu Yoshiyama, Sachiko Tsuchiya, Eiji Shigetomi, Tatsuya Miyamoto, Hiroshi Nakagomi, Keisuke Shibata, Tsutomu Mochizuki, Masayuki Takeda, Schuichi Koizumi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The role of the P2Y6 receptor in bladder function has recently attracted a great deal of attention in lower urinary tract research. We conducted this study to determine contributions of the P2Y6 receptor in lower urinary tract function of no
Externí odkaz:
https://doaj.org/article/dd34c3d825a442119d3e79bbd1e71e90
Autor:
Youichi Shinozaki, Alex Leung, Kazuhiko Namekata, Sei Saitoh, Huy Bang Nguyen, Akiko Takeda, Yosuke Danjo, Yosuke M. Morizawa, Eiji Shigetomi, Fumikazu Sano, Nozomu Yoshioka, Hirohide Takebayashi, Nobuhiko Ohno, Takahiro Segawa, Kunio Miyake, Kenji Kashiwagi, Takayuki Harada, Shin-ichi Ohnuma, Schuichi Koizumi
Publikováno v:
Science advances. 8(44)
Astrocyte abnormalities have received great attention for their association with various diseases in the brain but not so much in the eye. Recent independent genome-wide association studies of glaucoma, optic neuropathy characterized by retinal gangl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df1ce145d258a491c3792384583315d
https://pubmed.ncbi.nlm.nih.gov/36332025
https://pubmed.ncbi.nlm.nih.gov/36332025