Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Eiji, Ichimura"'
Autor:
Makoto Niwa, Naoko Igo, Akihiro Sekiguchi, Eiji Ichimura, Shintaro Hara, Yukina Ogawa, Aya Kikitsu, Junpei Konno, Keiichiro Yamamoto, Nao Yoneki, Tomohiro Hayashi, Kazuhisa Hara, Kan Saiga, Kimiko Fuchigami, Masayuki Mori, Kana Kawano, Yuki Kobayashi, Yuki Takashima, Takamichi Sato, Takashi Aijima, Hitomi Hayashi
Publikováno v:
Therapeutic Delivery. 9:711-729
Aim: Tacrolimus (TAC) is an important drug for inflammatory diseases. However, TAC has several limitations, such as variable trough concentrations among individuals and a high medication frequency. In this study, we created NK61060, a novel micellar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16194fcb7a6013c76c20bfdbd5dd030a
https://doi.org/10.4155/tde-2018-0044
https://doi.org/10.4155/tde-2018-0044
Autor:
Takeshi Onda, Hitomi Hayashi, Hiroko Mashiba, Iwao Nakamura, Akira Masuda, Daichi Nagai, Eiji Ichimura, Hirofumi Yokoyama, Rika Goda
Publikováno v:
International Journal of Nanomedicine
Iwao Nakamura, Eiji Ichimura, Rika Goda, Hitomi Hayashi, Hiroko Mashiba, Daichi Nagai, Hirofumi Yokoyama, Takeshi Onda, Akira Masuda Nanomedicine Group, Pharmaceutical Research Laboratories, Nippon Kayaku Co., Ltd., Tokyo, Japan Abstract: In our prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58635e692dc4ed29ea396d12a62685c
https://doi.org/10.2147/ijn.s114356
https://doi.org/10.2147/ijn.s114356
Autor:
Daichi Nagai, Osamu Miyazaki, Kazuya Okamoto, Eiji Ichimura, Yoshitaka Miyakawa, Tomio Morino, Keiko Ebara, Takeshi Onda, Keiko Sekine, Naoko Nakajima
Publikováno v:
International Journal of Cancer. 134:218-223
NK012 is a micelle-forming macromolecular prodrug of 7-ethyl-10-hydroxy camptothecin (SN-38), an active metabolite of irinotecan. It is accumulated and retained in tumor tissues and gradually releases SN-38 in an enzyme-independent manner. NK012 was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::960c4d238a6c9a93120d26a162743376
https://doi.org/10.1002/ijc.28333
https://doi.org/10.1002/ijc.28333
Autor:
Yasushi Matsuzaki, Mikio Doi, Eiji Ichimura, Kiyohiro Nishikawa, Arihiro Tomura, Daichi Nagai, Rika Goda
Publikováno v:
Journal of Gastroenterology. 41:231-239
Flutamide, a nonsteroidal antiandrogen used for treatment of prostate cancer, causes a temporary increase in transaminase and in some cases severe liver dysfunction. It is dominantly metabolized by cytochrome P450 (CYP) 1A2 into 2-hydroxyflutamide (O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e66bef58b7cb37e45b56ba75e9bf9ee
https://doi.org/10.1007/s00535-005-1749-y
https://doi.org/10.1007/s00535-005-1749-y
Autor:
Asuka Ogasawara, Masatoshi Abe, Eiji Ichimura, Yasuhiko Muraoka, Fuminori Abe, Megumi Ichinei, Tetsushi Saino, Chihiro Nishimura
Publikováno v:
The Journal of Antibiotics. 58:111-117
CD26, a membrane-bound ectopeptidase, is known as an activated T cell marker with dipeptidyl peptidase IV (DPPIV) activity that has diverse functional roles in the regulation of peptide hormones, neuropeptides, chemokines and growth factors. We recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff7dd5843d565f7db7891ee8921705a
https://doi.org/10.1038/ja.2005.14
https://doi.org/10.1038/ja.2005.14
Publikováno v:
Kanzo. 40:227-234
ラットを用いてフルタミドによる肝障害を作製し, 薬物性肝障害に対するウルソデオキシコール酸 (UDCA) の効果を検討した. 絶水絶食下でフェノバルビタールおよびフルタミド (150mg/kg) の5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c515e0856e888b77307b82d480ad0b4d
https://doi.org/10.2957/kanzo.40.227
https://doi.org/10.2957/kanzo.40.227
Autor:
Toshiya Yamaguchi, Iwao Nakamura, Keiko Ebara, Takafumi Ichida, Eiji Ichimura, Chihiro Nishimura, Hiroko Mashiba, Kazuya Okamoto, Naoko Nakajima, Takashi Kawashiro, Yuh-ichiro Ichikawa
Publikováno v:
Drug Discoveries & Therapeutics.
We conducted an in vivo study to evaluate the anticancer effect and toxicity of fine- powder cisplatin suspended in lipiodol (fCDDP/LPD suspension) after a single administration of three different doses to rats via the intrahepatic artery after trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a27c8e26b589b5964c01086a70e6b7
https://doi.org/10.5582/ddt.2013.v7.5.201
https://doi.org/10.5582/ddt.2013.v7.5.201
Autor:
Osamu, Miyazaki, Keiko, Sekine, Naoko, Nakajima, Eiji, Ichimura, Keiko, Ebara, Daichi, Nagai, Takeshi, Onda, Yoshitaka, Miyakawa, Kazuya, Okamoto, Tomio, Morino
Publikováno v:
International journal of cancer. 134(1)
NK012 is a micelle-forming macromolecular prodrug of 7-ethyl-10-hydroxy camptothecin (SN-38), an active metabolite of irinotecan. It is accumulated and retained in tumor tissues and gradually releases SN-38 in an enzyme-independent manner. NK012 was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a166c5dbe4373c49fe0cee7da092e241
https://pubmed.ncbi.nlm.nih.gov/23775066
https://pubmed.ncbi.nlm.nih.gov/23775066
Publikováno v:
Experimental Animals. 42:327-335
Effects of dehydration on the total area of the kidney occupied by renin-immunopositive cells were morphometrically studied on parasagittal sections by an image-analyzing system in the Mongolian gerbils. Changes in the body weight and plasma osmolari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a4ebab70c8b21308b6e37f7353107c
https://doi.org/10.1538/expanim1978.42.3_327
https://doi.org/10.1538/expanim1978.42.3_327
Autor:
Hiroko Mashiba, Hitomi Hayashi, Daichi Nagai, Norio Wake, Hiroaki Kobayashi, Eiji Ichimura, Kiyohiro Nishikawa, Iwao Nakamura, Kazuya Okamoto, Keiko Ebara
Publikováno v:
Arzneimittel-Forschung. 60(4)
Paclitaxel Inj. [NK] (test; paclitaxel, CAS 33069-62-4) is a generic version of the drug from the originator (reference). Both drugs contain the same active ingredient and showed identical pharmacokinetics in patients in the previous study; however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7adb2253616a6f985b4263fc5c3592
https://pubmed.ncbi.nlm.nih.gov/20486471
https://pubmed.ncbi.nlm.nih.gov/20486471