Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Eiichi Kamata"'
Autor:
Takashi Yamada, Akihiko Hirose, Eiichi Kamata, Yushiro Tanaka, Ovanes G. Mekenyan, Yasushi Yamazoe, Makoto Hayashi, Atsushi Ono, Ryuichi Hasegawa, Yuki Sakuratani, Jun Yamada
Publikováno v:
Regulatory Toxicology and Pharmacology. 65:189-195
We tested a category approach to predict the hepatotoxic effects of repeated doses of allyl esters using a new database for repeated-dose toxicity. Based on information on hepatotoxic mechanism of allyl acetate, the category was defined as allyl este
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceee992947e8f31b0095ce839f30a123
https://doi.org/10.1016/j.yrtph.2012.12.001
https://doi.org/10.1016/j.yrtph.2012.12.001
Autor:
Takeshi Yamazaki, Atsushi Ono, Yoshiharu Mirokuji, Masamitsu Honma, Mika Takahashi, Masami Yamada, Takayuki Fukumoto, Tomoko Kawamura, Hiroyuki Okamura, Kyoko Sato, Akihiko Hirose, Eiichi Kamata
Publikováno v:
Food and Chemical Toxicology. 50:1538-1546
Most exposure levels of flavor in food are considered to be extremely low. If at all, genotoxic properties should be taken into account in safety evaluations. We have recently established a (quantitative) structure–activity relationship, (Q)SAR, co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0964241c362c3d07f8a61f0b8d4c1378
https://doi.org/10.1016/j.fct.2012.02.009
https://doi.org/10.1016/j.fct.2012.02.009
Autor:
Masao Sunaga, Akihiko Hirose, Hina Kato, Hideki Serizawa, Atsushi Ono, Mutsuko Hirata-Koizumi, Eiichi Kamata, Mariko Matsumoto, Mika Takahashi
Publikováno v:
The Journal of Toxicological Sciences. 37:463-474
Three female Crl:CD(SD) rats/group were dosed with single wall carbon nanotube (SWCNT) or multi wall carbon nanotube (MWCNT) four times by gavage at a total of 50 mg/kg bw or 200 mg/kg bw (four equally divided doses at one-hour intervals). Acute oral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f108cb3440f4df39866edc626c6d78
https://doi.org/10.2131/jts.37.463
https://doi.org/10.2131/jts.37.463
Autor:
Yuki Sakuratani, Makoto Hayashi, Eiichi Kamata, Katsumi Kobayashi, Akihiko Hirose, Satoshi Nishikawa, Takemaru Abe, Jun Yamada, Kazuko Yamazaki
Publikováno v:
The Journal of Toxicological Sciences. 36:63-71
In order to understand the influence of coefficient of variation (CV) in determining significant difference of quantitative values of 28-day repeated-dose toxicity studies, we examined 59 parameters of 153 studies conducted in accordance with Chemica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac884dba29fc4ffd612e97c23d253fd1
https://doi.org/10.2131/jts.36.63
https://doi.org/10.2131/jts.36.63
Autor:
Megumi Yahata, Yuko Yamaguchi, Tomomi Nakazawa, Eiichi Kamata, Ryuichi Hasegawa, Kazutoshi Tamura, Shinichiro Ikezaki, Nobuo Nishimura, Ken-ichiro Kasahara, Hiroshi Edamoto, Makoto Ema
Publikováno v:
Journal of Toxicologic Pathology
In this study, we investigated the sequential changes in the development of renal tubular cysts in newborn rats treated with p-cumylphenol (PCP). Fifteen animals per sex were treated orally with 300 mg/kg/day of PCP for up to 18 days from postnatal d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4afb7d22a09af8feec123568c84928c5
http://europepmc.org/articles/PMC3246057
http://europepmc.org/articles/PMC3246057
Autor:
Takashi Matsuyama, Mutsuko Hirata-Koizumi, Akihiko Hirose, Mitsuhiko Kawabata, Kiyomi Matsuno, Eiichi Kamata, Kanako Yajima, Makoto Ema
Publikováno v:
Drug and Chemical Toxicology. 32:204-214
Previously, we showed that the toxic susceptibility of male rats to an ultraviolet absorber, 2-(2'-hydroxy- 3',5'-di-tert-butylphenyl)benzotriazole (HDBB), was nearly 25 times higher than that of females. The present study aimed to clarify the mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f33888b202bb1dfbbf0dcd60c17e817
https://doi.org/10.1080/01480540902862244
https://doi.org/10.1080/01480540902862244
Publikováno v:
Reproductive Toxicology. 25:231-238
Twelve male and female rats per group were given tetrahydrofurfuryl alcohol (THFA) by gavage at 0, 15, 50, 150 or 500 mg/kg/day. Males were dosed for 47 days, beginning 14 days before mating, and females were dosed for 42-52 days beginning 14 days be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1946f9a4e0169e4c22a5fa7d7b5c1fc
https://doi.org/10.1016/j.reprotox.2007.11.006
https://doi.org/10.1016/j.reprotox.2007.11.006
Autor:
Akihiko Hirose, Eiichi Kamata, Mutsuko Hirata-Koizumi, Mariko Matsumoto, Makoto Ema, Hiroaki Hara
Publikováno v:
Reproductive Toxicology. 25:89-99
The developmental neurotoxicity of polysorbate 80 (PS80) was evaluated in rats. Crl:CD(SD) rats were given drinking water containing PS80 at 0, 0.018, 0.13, 1.0, or 7.5% (0, 0.035, 0.245, 1.864, or 16.783 ml/kg bw/day) on day 0 of pregnancy through d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67e5c674d90e0ede35ad989944021d5
https://doi.org/10.1016/j.reprotox.2007.08.003
https://doi.org/10.1016/j.reprotox.2007.08.003
Autor:
Mutsuko Hirata-Koizumi, Takashi Matsuyama, Akihiko Hirose, Makoto Ema, Eiichi Kamata, Toshio Imai
Publikováno v:
Drug and Chemical Toxicology. 31:275-287
In our previous toxicity studies using young rats, we showed that an ultraviolet absorber, 2-(2'-hydroxy-3',5'-di-tert-butylphenyl)benzotriazole (HDBB), principally affected the liver, and male rats had nearly 25 times higher susceptibility to the to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc05522734824a0b4865a39d7f3d32cb
https://doi.org/10.1080/01480540701873368
https://doi.org/10.1080/01480540701873368
Autor:
K. Sadasivan Pillai, Takemaru Abe, Yuki Sakuratani, Katsumi Kobayashi, Makoto Hayashi, Eiichi Kamata
Publikováno v:
The Journal of Toxicological Sciences. 33:97-104
In order to know the different statistical tools used to analyze the data obtained from twenty-eight-day repeated dose oral toxicity studies with rodents and the impact of these statistical tools on interpretation of data obtained from the studies, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6cc77d95916b27a8b57816ce6338ee
https://doi.org/10.2131/jts.33.97
https://doi.org/10.2131/jts.33.97