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Autor:
Shuzo Okazaki, Eiich Yamazaki, Takayuki Aikawa, Kazutoshi Tamura, Kazuhisa Hatayama, Keitaro Terazawa, Akira Maruden
Publikováno v:
The Journal of Toxicological Sciences. 17:125-162
The chronic toxicity of FUT-187, a synthetic protease inhibitor, was investigated in Sprague-Dawley rats. FUT-187 was given orally to the rats at doses of 0.4, 2, 10, 50 and 250 mg/kg/day for 52 weeks. The drug was then withdrawn for 5 weeks. The res