Effect of 2 years of treatment with sublingual grass pollen immunotherapy on nasal response to allergen challenge at three years among patients with moderate to severe seasonal allergic rhinitis: The GRASS randomized clinical trial

Autor: Scadding, GW, Calderon, MA, Shamji, MH, Eifan, AO, Penagos, M, Dumitru, F, Sever, ML, Bahnson, HT, Lawson, K, Harris, KM, Plough, AG, Laurienzo Panza, J, Qin, T, Lim, N, Tchao, NK, Togias, A, Durham, SR

Importance Sublingual immunotherapy and subcutaneous immunotherapy are effective in seasonal allergic rhinitis. Three years of continuous treatment with subcutaneous immunotherapy and sublingual immunotherapy has been shown to improve symptoms for at

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http://hdl.handle.net/10044/1/44531

Nasal and blood transcriptomic pathways underpinning the clinical response to grass pollen immunotherapy.

Autor: Altman MC; Systems Immunology Division, Benaroya Research Institute, Seattle; Division of Allergy and Infectious Disease, Department of Medicine, University of Washington, Seattle. Electronic address: maltman@benaroyaresearch.org., Segnitz RM; Division of Allergy and Infectious Disease, Department of Medicine, University of Washington, Seattle., Larson D; Immune Tolerance Network, Bethesda., Jayavelu ND; Systems Immunology Division, Benaroya Research Institute, Seattle., Smith MT; Division of Allergy and Infectious Disease, Department of Medicine, University of Washington, Seattle., Patel S; Division of Allergy and Infectious Disease, Department of Medicine, University of Washington, Seattle., Scadding GW; Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Department of National Heart and Lung Institute, London., Qin T; Immune Tolerance Network, Bethesda., Sanda S; Madison Clinic for Pediatric Diabetes, University of California San Francisco, San Francisco., Steveling E; Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Department of National Heart and Lung Institute, London., Eifan AO; Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Department of National Heart and Lung Institute, London., Penagos M; Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Department of National Heart and Lung Institute, London., Jacobson MR; Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Department of National Heart and Lung Institute, London., Parkin RV; Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Department of National Heart and Lung Institute, London., Shamji MH; Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Department of National Heart and Lung Institute, London., Togias A; The National Institute of Allergy and Infectious Disease, Bethesda., Durham SR; Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Department of National Heart and Lung Institute, London.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2023 Nov; Vol. 152 (5), pp. 1247-1260. Date of Electronic Publication: 2023 Jul 15.

Repetitive nasal allergen challenge in allergic rhinitis: Priming and Th2-type inflammation but no evidence of remodelling.

Autor: Orban NT; Allergy and Clinical Immunology, National Heart and Lung Institute, Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, Faculty of Medicine, Imperial College London, London, UK.; Allergy Department, Royal Brompton and Harefield Hospitals NHS Trust, Imperial College London, London, UK., Jacobson MR; Allergy and Clinical Immunology, National Heart and Lung Institute, Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, Faculty of Medicine, Imperial College London, London, UK.; Allergy Department, Royal Brompton and Harefield Hospitals NHS Trust, Imperial College London, London, UK., Nouri-Aria KT; Allergy and Clinical Immunology, National Heart and Lung Institute, Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, Faculty of Medicine, Imperial College London, London, UK.; Allergy Department, Royal Brompton and Harefield Hospitals NHS Trust, Imperial College London, London, UK., Durham SR; Allergy and Clinical Immunology, National Heart and Lung Institute, Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, Faculty of Medicine, Imperial College London, London, UK.; Allergy Department, Royal Brompton and Harefield Hospitals NHS Trust, Imperial College London, London, UK., Eifan AO; Allergy and Clinical Immunology, National Heart and Lung Institute, Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, Faculty of Medicine, Imperial College London, London, UK.; Allergy Department, Royal Brompton and Harefield Hospitals NHS Trust, Imperial College London, London, UK.

Publikováno v: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology [Clin Exp Allergy] 2021 Feb; Vol. 51 (2), pp. 329-338. Date of Electronic Publication: 2020 Nov 30.

Effect of 2 Years of Treatment With Sublingual Grass Pollen Immunotherapy on Nasal Response to Allergen Challenge at 3 Years Among Patients With Moderate to Severe Seasonal Allergic Rhinitis: The GRASS Randomized Clinical Trial.

Autor: Scadding GW; Imperial College, London, and Royal Brompton and Harefield Hospitals NHS Foundation Trust, London, United Kingdom., Calderon MA; Imperial College, London, and Royal Brompton and Harefield Hospitals NHS Foundation Trust, London, United Kingdom., Shamji MH; Imperial College, London, and Royal Brompton and Harefield Hospitals NHS Foundation Trust, London, United Kingdom., Eifan AO; Imperial College, London, and Royal Brompton and Harefield Hospitals NHS Foundation Trust, London, United Kingdom., Penagos M; Imperial College, London, and Royal Brompton and Harefield Hospitals NHS Foundation Trust, London, United Kingdom., Dumitru F; Imperial College, London, and Royal Brompton and Harefield Hospitals NHS Foundation Trust, London, United Kingdom., Sever ML; Rho Federal Systems Division, Chapel Hill, North Carolina., Bahnson HT; Rho Federal Systems Division, Chapel Hill, North Carolina3currently with the Immune Tolerance Network, Benaroya Research Institute, Seattle, Washington., Lawson K; Rho Federal Systems Division, Chapel Hill, North Carolina., Harris KM; Immune Tolerance Network, Bethesda, Maryland., Plough AG; Immune Tolerance Network, San Francisco, California., Panza JL; National Institute of Allergy and Infectious Diseases, Rockville, Maryland., Qin T; Immune Tolerance Network, Bethesda, Maryland., Lim N; Immune Tolerance Network, Bethesda, Maryland., Tchao NK; Immune Tolerance Network, San Francisco, California7currently with the Department of Early Development Hematology/Oncology, Amgen, San Francisco, California., Togias A; National Institute of Allergy and Infectious Diseases, Rockville, Maryland., Durham SR; Imperial College, London, and Royal Brompton and Harefield Hospitals NHS Foundation Trust, London, United Kingdom.

Publikováno v: JAMA [JAMA] 2017 Feb 14; Vol. 317 (6), pp. 615-625.

Severe Persistent Allergic Rhinitis. Inflammation but No Histologic Features of Structural Upper Airway Remodeling.

Autor: Eifan AO; Allergy and Clinical Immunology, National Heart and Lung Institute, Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, Faculty of Medicine, Imperial College London, London, United Kingdom., Orban NT; Allergy and Clinical Immunology, National Heart and Lung Institute, Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, Faculty of Medicine, Imperial College London, London, United Kingdom., Jacobson MR; Allergy and Clinical Immunology, National Heart and Lung Institute, Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, Faculty of Medicine, Imperial College London, London, United Kingdom., Durham SR; Allergy and Clinical Immunology, National Heart and Lung Institute, Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, Faculty of Medicine, Imperial College London, London, United Kingdom.

Publikováno v: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2015 Dec 15; Vol. 192 (12), pp. 1431-9.