Cognitive and inflammatory heterogeneity in severe mental illness: Translating findings from blood to brain

Autor: Sæther, Linn Sofie, Szabo, Attila, Akkouh, Ibrahim A., Haatveit, Beathe, Mohn, Christine, Vaskinn, Anja, Aukrust, Pål, Ormerod, Monica B.E.G., Eiel Steen, Nils, Melle, Ingrid, Djurovic, Srdjan, Andreassen, Ole A., Ueland, Torill, Ueland, Thor

Publikováno v: In Brain Behavior and Immunity May 2024 118:287-299

Elevated Systemic Levels of Markers Reflecting Intestinal Barrier Dysfunction and Inflammasome Activation Are Correlated in Severe Mental Illness.

Autor: Jensen SB; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway., Sheikh MA; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway., Akkouh IA; Division of Mental Health and Addiction, Norwegian Centre for Mental Disorders Research, NORMENT, Oslo University Hospital, Oslo, Norway.; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway., Szabo A; Division of Mental Health and Addiction, Norwegian Centre for Mental Disorders Research, NORMENT, Oslo University Hospital, Oslo, Norway.; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.; K.G. Jebsen Center for Neurodevelopmental disorders, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., O'Connell KS; Division of Mental Health and Addiction, Norwegian Centre for Mental Disorders Research, NORMENT, Oslo University Hospital, Oslo, Norway., Lekva T; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway., Engh JA; Division of Mental Health and Addiction, Norwegian Centre for Mental Disorders Research, NORMENT, Oslo University Hospital, Oslo, Norway.; Division of Mental health and Addiction, Vestfold Hospital Trust, Tønsberg, Norway., Agartz I; K.G. Jebsen Center for Neurodevelopmental disorders, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.; Norwegian Centre for Mental Disorders Research, NORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Elvsåshagen T; Division of Mental Health and Addiction, Norwegian Centre for Mental Disorders Research, NORMENT, Oslo University Hospital, Oslo, Norway., Ormerod MBEG; Division of Mental Health and Addiction, Norwegian Centre for Mental Disorders Research, NORMENT, Oslo University Hospital, Oslo, Norway.; Norwegian Centre for Mental Disorders Research, NORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Weibell MA; Division of Psychiatry, Network for Clinical Psychosis Research, Stavanger University Hospital, Stavanger, Norway.; Network for Medical Sciences, Faculty of Health, University of Stavanger, Stavanger, Norway., Johnsen E; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Medicine, University of Bergen, Bergen, Norway.; NORMENT Center of Excellence, University of Bergen and Haukeland University Hospital, Bergen, Norway., Kroken RA; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Medicine, University of Bergen, Bergen, Norway.; NORMENT Center of Excellence, University of Bergen and Haukeland University Hospital, Bergen, Norway., Melle I; Division of Mental Health and Addiction, Norwegian Centre for Mental Disorders Research, NORMENT, Oslo University Hospital, Oslo, Norway.; Norwegian Centre for Mental Disorders Research, NORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Drange OK; Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Østmarka, Division of Mental Health, St. Olavs University Hospital, Trondheim, Norway.; Department of Psychiatry, Sørlandet Hospital, Kristiansand, Norway., Nærland T; K.G. Jebsen Center for Neurodevelopmental disorders, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Rare Disorders, Division of Child and Adolescent medicine, Oslo University Hospital, Oslo, Norway., Vaaler AE; Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Østmarka, Division of Mental Health, St. Olavs University Hospital, Trondheim, Norway., Westlye LT; Division of Mental Health and Addiction, Norwegian Centre for Mental Disorders Research, NORMENT, Oslo University Hospital, Oslo, Norway.; K.G. Jebsen Center for Neurodevelopmental disorders, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Psychology, University of Oslo, Oslo, Norway., Aukrust P; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.; Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Djurovic S; Division of Mental Health and Addiction, Norwegian Centre for Mental Disorders Research, NORMENT, Oslo University Hospital, Oslo, Norway.; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.; K.G. Jebsen Center for Neurodevelopmental disorders, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Psychology, University of Oslo, Oslo, Norway., Eiel Steen N; Division of Mental Health and Addiction, Norwegian Centre for Mental Disorders Research, NORMENT, Oslo University Hospital, Oslo, Norway.; Norwegian Centre for Mental Disorders Research, NORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Andreassen OA; Division of Mental Health and Addiction, Norwegian Centre for Mental Disorders Research, NORMENT, Oslo University Hospital, Oslo, Norway.; K.G. Jebsen Center for Neurodevelopmental disorders, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Norwegian Centre for Mental Disorders Research, NORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Ueland T; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; K.G. Jebsen Thrombosis Research and Expertise Center, University of Tromsø, Tromsø, Norway.

Publikováno v: Schizophrenia bulletin [Schizophr Bull] 2023 May 03; Vol. 49 (3), pp. 635-645.