Výsledky vyhledávání - "Eider Alcaraz"

Akademický článek

Quantitative determination of lurbinectedin, its unbound fraction and its metabolites in human plasma utilizing ultra-performance LC-MS/MS.

Autor: Nicholas King, Soledad Garcia-Martinez, Eider Alcaraz, Alba Grisalena, Rubin Lubomirov, Raquel Altares, Carlos Fernandez-Teruel, Andrés M Francesch, Pablo M Avilés, Salvador Fudio

Publikováno v: PLoS ONE, Vol 18, Iss 3, p e0283783 (2023)

AimsUltra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) methods to quantify total lurbinectedin, its plasma protein binding to derive the unbound fraction and its main metabolites 1',3'-dihydroxy-lurbinectedin (M4) and N-des

Externí odkaz: https://doaj.org/article/1aa8e01932bf4f71a6216d7bab2e09c9

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Bionalytical validation study for the determination of unbound ambrisentan in human plasma using rapid equilibrium dialysis followed by ultra performance liquid chromatography coupled to mass spectrometry

Autor: Miguel Angel Campanero, Nicholas King, Nerea Leal, Estitxu Rico, Enriqueta Casal, Iker Navarro, Eider Alcaraz, Soledad Garcia-Martínez, Alba Grisaleña

Publikováno v: Journal of pharmaceutical and biomedical analysis. 150

Ambrisentan is a highly selective endothelin-1 type A receptor antagonist indicated for use in the treatment of pulmonary hypertension. In this study an assay was developed and validated for the quantification of total and unbound (free) concentratio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e84c3df0f9f6dd0df483736d0f406de
https://pubmed.ncbi.nlm.nih.gov/29289894

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