New strategies for the first-line treatment of chronic myeloid leukemia: can resistance be avoided?

Autor: Snead JL, O'Hare T, Eide CA, Deininger MW

Publikováno v: Clinical Lymphoma & Myeloma; Mar2008 Supplement 3, Vol. 8, pS107-17, 1p

Targeting CCL2/CCR2 Signaling Overcomes MEK Inhibitor Resistance in Acute Myeloid Leukemia.

Autor: Modak RV; Division of Oncological Sciences, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon., de Oliveira Rebola KG; Division of Oncological Sciences, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon., McClatchy J; Division of Oncological Sciences, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon., Mohammadhosseini M; Division of Oncological Sciences, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon., Damnernsawad A; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon.; Department of Biology, Faculty of Science, Mahidol University, Bangkok, Thailand., Kurtz SE; Division of Oncological Sciences, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon., Eide CA; Division of Oncological Sciences, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon., Wu G; Division of Bioinformatics & Computational Biology, Oregon Health & Science University, Portland, Oregon., Laderas T; Division of Bioinformatics & Computational Biology, Oregon Health & Science University, Portland, Oregon., Nechiporuk T; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon., Gritsenko MA; Pacific Northwest National Laboratory, Richland, Washington., Hansen JR; Pacific Northwest National Laboratory, Richland, Washington., Hutchinson C; Pacific Northwest National Laboratory, Richland, Washington., Gosline SJC; Pacific Northwest National Laboratory, Richland, Washington.; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, Oregon., Piehowski P; Pacific Northwest National Laboratory, Richland, Washington., Bottomly D; Division of Bioinformatics & Computational Biology, Oregon Health & Science University, Portland, Oregon., Short N; Department of Leukemia, MD Anderson Cancer Center, Houston, Texas., Rodland K; Pacific Northwest National Laboratory, Richland, Washington., McWeeney SK; Division of Bioinformatics & Computational Biology, Oregon Health & Science University, Portland, Oregon., Tyner JW; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon., Agarwal A; Division of Oncological Sciences, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 May 15; Vol. 30 (10), pp. 2245-2259.

Patient-Specific Targeting of the T-Cell Receptor Variable Region as a Therapeutic Strategy in Clonal T-Cell Diseases.

Autor: Lucero OM; Department of Dermatology, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon., Lee JA; Clinical and Translational Science Institute, David Geffen School of Medicine, University of California, Los Angeles, California., Bowman J; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, Oregon., Johnson K; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, Oregon., Sapparapu G; Clinical and Translational Science Institute, David Geffen School of Medicine, University of California, Los Angeles, California., Thomas JK; Clinical and Translational Science Institute, David Geffen School of Medicine, University of California, Los Angeles, California., Fan G; Department of Pathology and Clinical Laboratory Medicine, Oregon Health & Science University, Portland, Oregon., Chang BH; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Division of Pediatric Hematology and Oncology, Oregon Health & Science University, Portland, Oregon., Thiel-Klare K; Division of Pediatric Hematology and Oncology, Oregon Health & Science University, Portland, Oregon., Eide CA; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, Oregon., Okada C; Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, Oregon., Palazzolo M; Clinical and Translational Science Institute, David Geffen School of Medicine, University of California, Los Angeles, California., Lind E; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, Oregon., Kosaka Y; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Division of Pediatric Hematology and Oncology, Oregon Health & Science University, Portland, Oregon., Druker BJ; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, Oregon.; VB Therapeutics LLC, Jackson, Wyoming., Lydon N; VB Therapeutics LLC, Jackson, Wyoming., Bowers PM; Therapeutic Antibody Laboratory, Department of Pulmonology and Critical Care, David Geffen School of Medicine, Los Angeles, California.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2023 Oct 13; Vol. 29 (20), pp. 4230-4241.

Loss of G0/G1 switch gene 2 (G0S2) promotes disease progression and drug resistance in chronic myeloid leukaemia (CML) by disrupting glycerophospholipid metabolism.

Autor: Gonzalez MA; Department of Molecular and Translational Medicine, Center of Emphasis in Cancer, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA., Olivas IM; Department of Molecular and Translational Medicine, Center of Emphasis in Cancer, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA.; L. Frederick Francis Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA., Bencomo-Alvarez AE; Department of Molecular and Translational Medicine, Center of Emphasis in Cancer, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA., Rubio AJ; Department of Molecular and Translational Medicine, Center of Emphasis in Cancer, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA.; Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA., Barreto-Vargas C; Immunology Division, University of Guadalajara, Guadalajara, Jalisco, Mexico., Lopez JL; Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA., Dang SK; L. Frederick Francis Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA.; Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA., Solecki JP; L. Frederick Francis Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA., McCall E; Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA., Astudillo G; Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA., Velazquez VV; Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA., Schenkel K; Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA., Reffell K; L. Frederick Francis Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA., Perkins M; Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA., Nguyen N; Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA., Apaflo JN; Metabolic, Nutrition and Exercise Research (MiNER) Laboratory, Department of Kinesiology, University of Texas at El Paso, El Paso, Texas, USA., Alvidrez E; Department of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, Texas, USA., Young JE; L. Frederick Francis Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA., Lara JJ; L. Frederick Francis Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA.; Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA., Yan D; Huntsman Cancer Institute, The University of Utah, Salt Lake City, Utah, USA., Senina A; Huntsman Cancer Institute, The University of Utah, Salt Lake City, Utah, USA., Ahmann J; Huntsman Cancer Institute, The University of Utah, Salt Lake City, Utah, USA., Varley KE; Huntsman Cancer Institute, The University of Utah, Salt Lake City, Utah, USA., Mason CC; Huntsman Cancer Institute, The University of Utah, Salt Lake City, Utah, USA., Eide CA; Knight Cancer Institute, Division of Hematology/Medical Oncology, Oregon Health & Science University, Portland, Oregon, USA., Druker BJ; Knight Cancer Institute, Division of Hematology/Medical Oncology, Oregon Health & Science University, Portland, Oregon, USA., Nurunnabi M; Department of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, Texas, USA., Padilla O; Department of Pathology, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA., Bajpeyi S; Metabolic, Nutrition and Exercise Research (MiNER) Laboratory, Department of Kinesiology, University of Texas at El Paso, El Paso, Texas, USA., Eiring AM; Department of Molecular and Translational Medicine, Center of Emphasis in Cancer, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA.; L. Frederick Francis Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA.; Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, Texas, USA.

Publikováno v: Clinical and translational medicine [Clin Transl Med] 2022 Dec; Vol. 12 (12), pp. e1146.

Integrative analysis of drug response and clinical outcome in acute myeloid leukemia.

Autor: Bottomly D; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Long N; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Schultz AR; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Kurtz SE; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Tognon CE; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Johnson K; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Abel M; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Agarwal A; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA; Department of Molecular & Medical Genetics, Oregon Health & Science University, Portland, OR 97239, USA; Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Avaylon S; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Benton E; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR 97239, USA., Blucher A; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Borate U; Division of Hematology, Department of Internal Medicine, James Cancer Center, Ohio State University, Columbus, OH 43210, USA., Braun TP; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Brown J; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Bryant J; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Burke R; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Carlos A; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Integrated Genomics Laboratory, Oregon Health & Science University, Portland, OR 97239, USA., Chang BH; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology and Oncology, Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA., Cho HJ; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239, USA., Christy S; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Coblentz C; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Cohen AM; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR 97239, USA., d'Almeida A; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Cook R; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Danilov A; Department of Hematology and Hematopoietic Stem Cell Transplant, City of Hope National Medical Center, Duarte, CA 91010, USA., Dao KT; Astex Pharmaceuticals, Cambridge, CB4 0QA, UK., Degnin M; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Dibb J; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Eide CA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., English I; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Hagler S; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR 97239, USA., Harrelson H; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR 97239, USA., Henson R; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Integrated Genomics Laboratory, Oregon Health & Science University, Portland, OR 97239, USA., Ho H; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Joshi SK; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Junio B; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Kaempf A; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Biostatistics Shared Resource, Oregon Health & Science University, Portland, OR 97239, USA., Kosaka Y; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239, USA., Laderas T; DNA Nexus, Mountain View, CA 94040, USA., Lawhead M; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR 97239, USA., Lee H; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Leonard JT; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Lin C; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Integrated Genomics Laboratory, Oregon Health & Science University, Portland, OR 97239, USA., Lind EF; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239, USA., Liu SQ; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Lo P; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Loriaux MM; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Pathology, Oregon Health & Science University, Portland, OR 97239, USA., Luty S; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Maxson JE; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Macey T; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Martinez J; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Minnier J; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Biostatistics Shared Resource, Oregon Health & Science University, Portland, OR 97239, USA; OHSU-PSU School of Public Health, VA Portland Health Care System, Oregon Health & Science University, Portland, OR 97239, USA., Monteblanco A; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Mori M; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Morrow Q; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Nelson D; High-Throughput Screening Services Laboratory, Oregon State University, Corvallis, OR 97331, USA., Ramsdill J; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR 97239, USA., Rofelty A; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Rogers A; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Romine KA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Ryabinin P; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Saultz JN; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Sampson DA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Savage SL; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Schuff R; Ochin Inc., Portland, OR 97228, USA., Searles R; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Integrated Genomics Laboratory, Oregon Health & Science University, Portland, OR 97239, USA., Smith RL; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Spurgeon SE; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Sweeney T; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Swords RT; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Thapa A; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Thiel-Klare K; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Traer E; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Wagner J; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Wilmot B; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR 97239, USA., Wolf J; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Wu G; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR 97239, USA., Yates A; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR 97239, USA., Zhang H; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Oncologic Sciences, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Cogle CR; Department of Medicine, Division of Hematology and Oncology, University of Florida, Gainesville, FL 32610, USA., Collins RH; Department of Internal Medicine/ Hematology Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390-8565, USA., Deininger MW; Division of Hematology & Hematologic Malignancies, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA., Hourigan CS; National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20814-1476, USA., Jordan CT; Division of Hematology, University of Colorado, Denver, CO 80045, USA., Lin TL; Division of Hematologic Malignancies & Cellular Therapeutics, University of Kansas, Kansas City, KS 66205, USA., Martinez ME; Clinical Research Services, University of Miami Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA., Pallapati RR; Clinical Research Services, University of Miami Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA., Pollyea DA; Division of Hematology, University of Colorado, Denver, CO 80045, USA., Pomicter AD; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA., Watts JM; Division of Hematology, Department of Medicine, University of Miami Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA., Weir SJ; Department of Cancer Biology, Division of Medical Oncology, Department of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA., Druker BJ; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Division of Hematology & Medical Oncology, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: drukerb@ohsu.edu., McWeeney SK; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: mcweeney@ohsu.edu., Tyner JW; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: tynerj@ohsu.edu.

Publikováno v: Cancer cell [Cancer Cell] 2022 Aug 08; Vol. 40 (8), pp. 850-864.e9. Date of Electronic Publication: 2022 Jul 21.