Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Eichi, Tsuruga"'
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 8, Pp 6262-6271 (2023)
Radiation therapy is commonly used to treat head and neck squamous cell carcinoma (HNSCC); however, recurrence results from the development of radioresistant cancer cells. Therefore, it is necessary to identify the underlying mechanisms of radioresis
Externí odkaz:
https://doaj.org/article/1e6eccbb41384c32a696e1ac78773e92
Autor:
Kazuki Hasegawa, Ryo Saga, Kentaro Ohuchi, Yoshikazu Kuwahara, Kazuo Tomita, Kazuhiko Okumura, Tomoaki Sato, Manabu Fukumoto, Eichi Tsuruga, Yoichiro Hosokawa
Publikováno v:
Cells, Vol 11, Iss 23, p 3780 (2022)
Radioresistant (RR) cells are poor prognostic factors for tumor recurrence and metastasis after radiotherapy. The hyaluronan (HA) synthesis inhibitor, 4-methylumbelliferone (4-MU), shows anti-tumor and anti-metastatic effects through suppressing HA s
Externí odkaz:
https://doaj.org/article/e8f4a19d15614a2992999b86da318b05
Publikováno v:
Journal of Radiation Research. 64:520-529
Mitochondria play important roles in the cellular response to various types of stress, including that triggered by ionizing radiation. We have previously reported that the mitochondrial ribosomal protein death-associated protein 3 (DAP3) regulates th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81f6f8cfaaa2c5be27f264e6892c7510
https://doi.org/10.1093/jrr/rrad016
https://doi.org/10.1093/jrr/rrad016
Publikováno v:
Cells, Vol 11, Iss 9, p 1434 (2022)
Cyclic GMP-AMP synthase (cGAS) plays an important role in biological responses to pathogens. The activation of the cGAS pathway in immune cells is known to induce antitumor effects, but the role of cGAS in cancer cells remains poorly understood. In s
Externí odkaz:
https://doaj.org/article/b820d7005e1040c4b3f895dfd6f4754d
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 420 (2021)
Retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs) mediate anti-viral response through mitochondria. In addition, RLR activation induces anti-tumor effects on various cancers. We previously reported that the RLR agonist Poly(I:C)-HMW/LyoVec
Externí odkaz:
https://doaj.org/article/9fe4dd432a2e4bd095a7c709c769b580
Autor:
Kentaro Ohuchi, Ryo Saga, Kazuki Hasegawa, Eichi Tsuruga, Yoichiro Hosokawa, Manabu Fukumoto, Kazuhiko Okumura
Publikováno v:
Biomed Rep
Radioresistant cancer cells lead to poor prognosis after radiotherapy. However, the mechanisms underlying cancer cell radioresistance have not been fully elucidated. Thus, the DNA damage response of clinically relevant radioresistant oral squamous ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a31169dae750813c7e5efd9258794d
https://europepmc.org/articles/PMC10011949/
https://europepmc.org/articles/PMC10011949/
Publikováno v:
ACTA HISTOCHEMICA ET CYTOCHEMICA. 54:1-9
The ciliary zonules, also known as the zonules of Zinn, help to control the thickness of the lens during focusing. The ciliary zonules are composed of oxytalan fibers, which are synthesized by human nonpigmented ciliary epithelial cells (HNPCEC). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afe0768101440474c08f06adeed568e0
https://doi.org/10.1267/ahc.20-00021
https://doi.org/10.1267/ahc.20-00021
Publikováno v:
Current Cancer Drug Targets. 20:372-381
Background: Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) play key roles in the antiviral response, but recent works show that RLR activation elicits anticancer activity as well, including apoptosis. Previously, we demonstrated that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::722939155321fde43fad9a18627bc675
https://doi.org/10.2174/1568009620666200115161717
https://doi.org/10.2174/1568009620666200115161717
Autor:
Yuji Hatakeyama, Junko Hatakeyama, Atsushi Takahashi, Kyoko Oka, Eichi Tsuruga, Tetsuichiro Inai, Yoshihiko Sawa
Publikováno v:
Drug Target Insights, Vol 2011, Iss 5, Pp 1-9 (2011)
Externí odkaz:
https://doaj.org/article/f85a5e08876a4717bb7df76786ecac31
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97165 (2014)
The toll-like receptor (TLR) has been suggested as a candidate cause for diabetic nephropathy. Recently, we have reported the TLR4 expression in diabetic mouse glomerular endothelium. The study here investigates the effects of the periodontal pathoge
Externí odkaz:
https://doaj.org/article/994aea40133c41c9b1416734919adf01