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SHP2 inhibitors maintain TGFβ signalling through SMURF2 inhibition.

Autor: Lai X; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore., Lui SKL; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Lam HY; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore., Adachi Y; Division of Molecular Therapeutics, Aichi Cancer Center Research Institute, Nagoya, Aichi, 464-8681, Japan.; Division of Advanced Cancer Therapeutics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466-8650, Japan., Sim WJ; Institute of Molecular and Cell Biology, A*STAR, Singapore, 138672, Singapore., Vasilevski N; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia., Armstrong NJ; School of Electrical Engineering, Computing and Mathematical Sciences, Faculty of Science and Engineering, Curtin University, Bentley, WA, 6102, Australia., Bridgeman SC; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia., Main NM; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia., Tan TZ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Tirnitz-Parker JEE; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia., Thiery JP; Institute of Molecular and Cell Biology, A*STAR, Singapore, 138672, Singapore. tjp@visitor.nus.edu.sg.; Guangzhou Laboratory, Guangzhou International Bio Island, Haizhu District, Guangzhou, Guangdong, 510530, China. tjp@visitor.nus.edu.sg., Ebi H; Division of Molecular Therapeutics, Aichi Cancer Center Research Institute, Nagoya, Aichi, 464-8681, Japan. hebi@aichi-cc.jp.; Division of Advanced Cancer Therapeutics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466-8650, Japan. hebi@aichi-cc.jp., Kumar AP; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore, Singapore. apkumar@nus.edu.sg.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore. apkumar@nus.edu.sg., Eichhorn PJA; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. Pieter.eichhorn@curtin.edu.au.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore. Pieter.eichhorn@curtin.edu.au.; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia. Pieter.eichhorn@curtin.edu.au.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia. Pieter.eichhorn@curtin.edu.au.

Publikováno v: NPJ precision oncology [NPJ Precis Oncol] 2023 Dec 15; Vol. 7 (1), pp. 136. Date of Electronic Publication: 2023 Dec 15.

TGF-β, EMT, and resistance to anti-cancer treatment.

Autor: Wang X; Guangzhou National Laboratory, Guangzhou, China; Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. Electronic address: wang_xuecong@gzlab.ac.cn., Eichhorn PJA; Curtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, GPO Box U1987, Perth, WA 6845, Australia; Curtin Medical School, Curtin University, GPO Box U1987, Perth, WA 6845, Australia; Cancer Science Institute of Singapore, National University of Singapore, 117599 Singapore, Singapore., Thiery JP; Guangzhou National Laboratory, Guangzhou, China. Electronic address: tjp@gzlab.ac.cn.

Publikováno v: Seminars in cancer biology [Semin Cancer Biol] 2023 Dec; Vol. 97, pp. 1-11. Date of Electronic Publication: 2023 Nov 08.

OTUD4 enhances TGFβ signalling through regulation of the TGFβ receptor complex.

Autor: Jaynes PW; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Iyengar PV; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; Department of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center, 2333 ZC, Leiden, The Netherlands., Lui SKL; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Tan TZ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Vasilevski N; School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin University, Bentley, 6102, Australia.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia., Wright SCE; School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin University, Bentley, 6102, Australia.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia., Verdile G; School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin University, Bentley, 6102, Australia.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia.; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, 6027, Australia., Jeyasekharan AD; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Eichhorn PJA; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. Pieter.eichhorn@curtin.edu.au.; School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin University, Bentley, 6102, Australia. Pieter.eichhorn@curtin.edu.au.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia. Pieter.eichhorn@curtin.edu.au.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore. Pieter.eichhorn@curtin.edu.au.

Publikováno v: Scientific reports [Sci Rep] 2020 Sep 24; Vol. 10 (1), pp. 15725. Date of Electronic Publication: 2020 Sep 24.

USP26 regulates TGF-β signaling by deubiquitinating and stabilizing SMAD7.

Autor: Kit Leng Lui S, Iyengar PV, Jaynes P, Isa ZFBA, Pang B, Tan TZ, Eichhorn PJA

Publikováno v: EMBO reports [EMBO Rep] 2020 Jan 07; Vol. 21 (1), pp. e49618. Date of Electronic Publication: 2019 Dec 20.