SHP2 inhibitors maintain TGFβ signalling through SMURF2 inhibition.

Autor: Lai X; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore., Lui SKL; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Lam HY; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore., Adachi Y; Division of Molecular Therapeutics, Aichi Cancer Center Research Institute, Nagoya, Aichi, 464-8681, Japan.; Division of Advanced Cancer Therapeutics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466-8650, Japan., Sim WJ; Institute of Molecular and Cell Biology, A*STAR, Singapore, 138672, Singapore., Vasilevski N; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia., Armstrong NJ; School of Electrical Engineering, Computing and Mathematical Sciences, Faculty of Science and Engineering, Curtin University, Bentley, WA, 6102, Australia., Bridgeman SC; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia., Main NM; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia., Tan TZ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Tirnitz-Parker JEE; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia., Thiery JP; Institute of Molecular and Cell Biology, A*STAR, Singapore, 138672, Singapore. tjp@visitor.nus.edu.sg.; Guangzhou Laboratory, Guangzhou International Bio Island, Haizhu District, Guangzhou, Guangdong, 510530, China. tjp@visitor.nus.edu.sg., Ebi H; Division of Molecular Therapeutics, Aichi Cancer Center Research Institute, Nagoya, Aichi, 464-8681, Japan. hebi@aichi-cc.jp.; Division of Advanced Cancer Therapeutics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, 466-8650, Japan. hebi@aichi-cc.jp., Kumar AP; NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore, Singapore. apkumar@nus.edu.sg.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore. apkumar@nus.edu.sg., Eichhorn PJA; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. Pieter.eichhorn@curtin.edu.au.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore. Pieter.eichhorn@curtin.edu.au.; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia. Pieter.eichhorn@curtin.edu.au.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley, WA, 6102, Australia. Pieter.eichhorn@curtin.edu.au.

Publikováno v: NPJ precision oncology [NPJ Precis Oncol] 2023 Dec 15; Vol. 7 (1), pp. 136. Date of Electronic Publication: 2023 Dec 15.

TGF-β, EMT, and resistance to anti-cancer treatment.

Autor: Wang X; Guangzhou National Laboratory, Guangzhou, China; Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. Electronic address: wang_xuecong@gzlab.ac.cn., Eichhorn PJA; Curtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, GPO Box U1987, Perth, WA 6845, Australia; Curtin Medical School, Curtin University, GPO Box U1987, Perth, WA 6845, Australia; Cancer Science Institute of Singapore, National University of Singapore, 117599 Singapore, Singapore., Thiery JP; Guangzhou National Laboratory, Guangzhou, China. Electronic address: tjp@gzlab.ac.cn.

Publikováno v: Seminars in cancer biology [Semin Cancer Biol] 2023 Dec; Vol. 97, pp. 1-11. Date of Electronic Publication: 2023 Nov 08.

Mechanisms of Resistance to PI3K Inhibitors in Cancer: Adaptive Responses, Drug Tolerance and Cellular Plasticity.

Autor: Wright SCE; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley 6102, Australia.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley 6102, Australia., Vasilevski N; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley 6102, Australia.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley 6102, Australia., Serra V; Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron University Hospital, 08035 Barcelona, Spain., Rodon J; Investigational Cancer Therapeutics Department, MD Anderson Cancer Center, Houston, TX 77030, USA., Eichhorn PJA; Curtin Medical School, Faculty of Health Sciences, Curtin University, Bentley 6102, Australia.; Curtin Health Innovation Research Institute and Faculty of Health Sciences, Curtin University, Bentley 6102, Australia.; Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

Publikováno v: Cancers [Cancers (Basel)] 2021 Mar 26; Vol. 13 (7). Date of Electronic Publication: 2021 Mar 26.

The Syvn1 inhibits neuronal cell ferroptosis by activating Stat3/Gpx4 axis in rat with spinal cord injury.

Autor: Xiao, Shining^1,2,3 (AUTHOR), Zhang, Yu^1,2,3 (AUTHOR), Wang, Shijiang^1,2,3 (AUTHOR), Liu, Jiaming^1,2 (AUTHOR), Dan, Fan^1,2,3 (AUTHOR), Yang, Feng^1,2,3 (AUTHOR), Hong, Shue¹ (AUTHOR), Liu, Ning⁴ (AUTHOR), Zeng, Yujia⁵ (AUTHOR), Huang, Ke⁵ (AUTHOR), Xie, Xinsheng³ (AUTHOR), Zhong, Yanxin^1,2,3 (AUTHOR), Liu, Zhili^1,2,3 (AUTHOR) zhili-liu@ncu.edu.cn

Publikováno v: Cell Proliferation. Oct2024, Vol. 57 Issue 10, p1-14. 14p.

Recruitment of USP10 by GCS1 to deubiquitinate GRP78 promotes the progression of colorectal cancer via alleviating endoplasmic reticulum stress.

Autor: Chen, Yang^1,2 (AUTHOR), Shen, Hengyang^1,2 (AUTHOR), Wang, Zhenling^1,2 (AUTHOR), Huang, Changzhi^1,2 (AUTHOR), Zhang, Hongqiang^1,2 (AUTHOR), Shao, Yu^1,2 (AUTHOR), Tong, Ying^1,2 (AUTHOR), Xu, Lei^1,2 (AUTHOR), Lu, Yunfei^1,2 (AUTHOR), Fu, Zan^1,2 (AUTHOR) fuzan1971@njmu.edu.cn

Publikováno v: Journal of Experimental & Clinical Cancer Research (17569966). 9/13/2024, Vol. 43 Issue 1, p1-17. 17p.