Discovery of highly potent and selective pan-Aurora kinase inhibitors with enhanced in vivo antitumor therapeutic index.

Autor: Liu G; Department of Medicinal Chemistry, Ambit Biosciences Corporation, 4215 Sorrento Valley Boulevard, San Diego, California 92121, USA. gliu@ambitbio.com, Abraham S, Tran L, Vickers TD, Xu S, Hadd MJ, Quiambao S, Holladay MW, Hua H, Ford Pulido JM, Gunawardane RN, Davis MI, Eichelberger SR, Apuy JL, Gitnick D, Gardner MF, James J, Breider MA, Belli B, Armstrong RC, Treiber DK

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2012 Apr 12; Vol. 55 (7), pp. 3250-60. Date of Electronic Publication: 2012 Mar 14.