Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Eian Caulder"'
Autor:
Jun Li, Margaret Favata, Jennifer A. Kelley, Eian Caulder, Beth Thomas, Xiaoming Wen, Richard B. Sparks, Ari Arvanitis, James D. Rogers, Andrew P. Combs, Kris Vaddi, Kimberly A. Solomon, Peggy A. Scherle, Robert Newton, Jordan S. Fridman
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 1, Pp 28-38 (2010)
Cytokines in the bone marrow of multiple myeloma patients activate Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathways in tumor cells and promote tumor growth, survival, and drug resistance. INCB16562 was dev
Externí odkaz:
https://doaj.org/article/8ff70b38f3cd4dcba837d81f78e72017
Autor:
Jordan S. Fridman, Kris Vaddi, Timothy C. Burn, James D. Rodgers, Andrew P. Combs, Richard B. Sparks, Patrick Haley, Gregory Hollis, Erin Crowgey, Yanlong Li, Mary Becker-Pasha, Richard Wynn, Alex Margulis, Paul Waeltz, Jun Li, Eian Caulder, Phillip C.C. Liu
Supplementary Data from Combined Inhibition of Janus Kinase 1/2 for the Treatment of JAK2V617F-Driven Neoplasms: Selective Effects on Mutant Cells and Improvements in Measures of Disease Severity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e47b931a262ce765e455bcf760d62f8
https://doi.org/10.1158/1078-0432.22440651
https://doi.org/10.1158/1078-0432.22440651
Autor:
Jordan S. Fridman, Timothy Burn, Jun Li, Eian Caulder, Kris Vaddi, Mary Becker-Pasha, Yanlong Li, Gregory F. Hollis, Andrew P. Combs, Paul Waeltz, James D. Rodgers, Patrick J. Haley, Richard Wynn, Alex Margulis, Richard B. Sparks, Erin Crowgey, Phillip Liu
Publikováno v:
Clinical Cancer Research. 15:6891-6900
Purpose: Deregulation of the Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway is a hallmark for the Philadelphia chromosomenegative myeloproliferative diseases polycythemia vera, essential thrombocythemia, and primar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac5c7560ca92343540b2fe47fa1e78df
https://doi.org/10.1158/1078-0432.ccr-09-1298
https://doi.org/10.1158/1078-0432.ccr-09-1298
Autor:
Eian Caulder, Peggy Scherle, Steven Friedman, Allan Lipton, Lois Witters, Robert C. Newton, Jordan S. Fridman
Publikováno v:
Cancer Research. 68:7083-7089
The ErbB family of receptors is overexpressed in numerous human tumors. Overexpression correlates with poor prognosis and resistance to therapy. Use of ErbB-specific antibodies to the receptors (Herceptin or Erbitux) or ErbB-specific small-molecule i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9950f8b6a7ac4564ca1507568dfca045
https://doi.org/10.1158/0008-5472.can-08-0739
https://doi.org/10.1158/0008-5472.can-08-0739
Autor:
Kris Vaddi, Jordan S. Fridman, Jincong Zhuo, Qian Wang, Genjie Yang, Sufi M. Thomas, Bin-Bing S. Zhou, Maxwell Pan, Wenqing Yao, Steven Friedman, Xiangdong Liu, Robert C. Newton, Eian Caulder, Peggy Scherle, Michael Hansbury, Yvonne Lo, Jennifer R. Grandis
Publikováno v:
Clinical Cancer Research. 13:1892-1902
Purpose: ErbB receptor signaling pathways are important regulators of cell fate, and their dysregulation, through (epi)genetic alterations, plays an etiologic role in multiple cancers. ErbB ligands are synthesized as membrane-bound precursors that ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67ed23d732619a72b311c50b95bb0cb
https://doi.org/10.1158/1078-0432.ccr-06-2116
https://doi.org/10.1158/1078-0432.ccr-06-2116
Autor:
Lingkai Weng, Qiyan Lin, Ravi Kumar Jalluri, Eric Shi, Maryanne Covington, Ding-Quan Qian, Peggy Scherle, Timothy Burn, Jordan S. Fridman, Kamna Katiyar, Costas Agrios, Max Pan, Kris Vaddi, Changnian Liu, Zelda Wasserman, Nancy Taylor, Eian Caulder, Wenqing Yao, Robert C. Newton, Gregory Hollis, Steven Friedman, Yanlong Li, Bing-Bing Zhou, Yun-Long Li, Michael J. Bower, Chunhong He, Xiangdong Liu, Colin Zhang, Jincong Zhuo, Meizhong Xu, Swamy Yeleswaram, David M. Burns, Cindy A. Marando, Richard Wynn, Brian Metcalf
Publikováno v:
Journal of Medicinal Chemistry. 50:603-606
The design, synthesis, evaluation, and identification of a novel class of (6S,7S)-N-hydroxy-6-carboxamide-5-azaspiro[2.5]octane-7-carboxamides as the first potent and selective inhibitors of human epidermal growth factor receptor-2 (HER-2) sheddase i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baef3a8ed08b12286d84bda86fa256d1
https://doi.org/10.1021/jm061344o
https://doi.org/10.1021/jm061344o
Autor:
Alfonso Quintás-Cardama, Taghi Manshouri, Hagop M. Kantarjian, Jun Li, Eian Caulder, Peggy Scherle, Phillip Liu, Jordan S. Fridman, Timothy Burn, Stacey Shepard, Paul Waeltz, Srdan Verstovsek, Kris Vaddi, Jennifer Kelley, Mark Rupar, Xiaoming Wen, James D. Rodgers, Yanlong Li, Patrick J. Haley, Yvonne Lo, Maryanne Covington
Constitutive JAK2 activation in hematopoietic cells by the JAK2V617F mutation recapitulates myeloproliferative neoplasm (MPN) phenotypes in mice, establishing JAK2 inhibition as a potential therapeutic strategy. Although most polycythemia vera patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb046210000ab246865615ac84729b54
https://europepmc.org/articles/PMC3953826/
https://europepmc.org/articles/PMC3953826/
Autor:
Ari Arvanitis, Robert C. Newton, Beth Thomas, Kris Vaddi, Andrew P. Combs, Eian Caulder, Jun Li, Jordan S. Fridman, Xiaoming Wen, James D. Rogers, Kimberly A. Solomon, Richard B. Sparks, Margaret Favata, Jennifer Kelley, Peggy Scherle
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 1, Pp 28-38 (2010)
Cytokines in the bone marrow of multiple myeloma patients activate Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathways in tumor cells and promote tumor growth, survival, and drug resistance. INCB16562 was dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b42fd6ac04e1aa5c6aaf88d86c028fa
https://europepmc.org/articles/PMC2805881/
https://europepmc.org/articles/PMC2805881/
Autor:
Martin Gramatzki, Renate Burger, Dharminder Chauhan, Reshma Shringarpure, Kris Vaddi, Yu-Tzu Tai, Jun Li, Paola Neri, Pierfrancesco Tassone, Jordan S. Fridman, Kenneth C. Anderson, Laurence Catley, Steven Le Gouill, Eian Caulder, Klaus Podar, Claire L. Neilan, Teru Hideshima
Protein tyrosine kinases of the Janus kinase (JAK) family are associated with many cytokine receptors, which, on ligand binding, regulate important cellular functions such as proliferation, survival, and differentiation. In multiple myeloma, JAKs may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e754675a13ac15f2a61a1428471310
https://europepmc.org/articles/PMC3418602/
https://europepmc.org/articles/PMC3418602/
Autor:
Padmaja Polam, Kris Vaddi, Reid Huber, Valerie Dostalik, Nikoo Falahatpisheh, Xuesong M. Liu, Thomas Maduskuie, Richard B. Sparks, Sybil O'Connor, Peggy Scherle, Gregory Hollis, Timothy Burn, Chu-Biao Xue, Andrew P. Combs, Eian Caulder, Phillip Liu, Xiaoming Wen, Taisheng Huang, Matthew C. Stubbs, Alla Vogina
Publikováno v:
Cancer Research. 75:691-691
Multiple myeloma (MM) is a disease of plasma cell transformation. Current therapy for MM is initially effective, but nearly all tumors relapse, making new therapeutic options a necessity. Due to their efficacy in MM models, small molecule inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d69bbd97b2420203dc98430ec9c7a8b7
https://doi.org/10.1158/1538-7445.am2015-691
https://doi.org/10.1158/1538-7445.am2015-691