Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ei-Ichi Nakai"'
Autor:
Hideki Anan, Yoshiya Terai, Hitoshi Sakashita, Koichiro Morihira, Ei-Ichi Nakai, Tadao Shibanuma, Yasuhiro Yonetoku, Yoshinori Okamoto, Makoto Takeuchi, Hiroyuki Kurihara, Yasuo Isomura
Publikováno v:
Chemical and Pharmaceutical Bulletin. 47:11-21
Based on the X-ray structure of the complex of Ac-Tyr-Val-Ala-Asp-H (L-709049) and interleukin-1 beta converting enzyme (ICE), we synthesized compounds which were derived from 2-NapCO-Val-Pro-Asp-CH2OPh (1) to obtain a potent inhibitor in the cell as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcea4efe03d68e2c5e910f4dc7cef5de
https://doi.org/10.1248/cpb.47.11
https://doi.org/10.1248/cpb.47.11
Publikováno v:
Tetrahedron Letters. 37:3005-3008
The titled Claisen modification is shown to proceed with a remarkably high level of diastereoselection and asymmetric transmission by virtue of the proper choice of the combination of the silyl triflate and the tertiary amine used.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d16399e718c500aebd784f920f5ab166
https://doi.org/10.1016/0040-4039(96)00485-6
https://doi.org/10.1016/0040-4039(96)00485-6
Publikováno v:
ChemInform. 27
The titled Claisen modification is shown to proceed with a remarkably high level of diastereoselection and asymmetric transmission by virtue of the proper choice of the combination of the silyl triflate and the tertiary amine used.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f7cf2c427a3b7daa321c9182891dffd
https://doi.org/10.1002/chin.199632062
https://doi.org/10.1002/chin.199632062
Publikováno v:
Chemistry Letters. 14:1725-1728
Three [2,3]Wittig-based approaches for stereocontrol over three contiguous chiral centers are described within the synthesis of the title lactone. In these methods, the erythro-selective [2,3]Wittig variants are combined with one of the stereoselecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2648164b1fed4a9c41ac9a6d5e40d70d
https://doi.org/10.1246/cl.1985.1725
https://doi.org/10.1246/cl.1985.1725
Autor:
Takeshi Nakai, Ei-ichi Nakai
Publikováno v:
Tetrahedron Letters. 29:4587-4590
The [2,3]Wittig rearrangements of allylic ethers with a chiral substituent at the γ-positions, derived from ( S )-lactaldehyde and ( R )-glyceraldehyde, are shown to exhibit an extremely high asymmetric induction, together with a high simple diaster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2667b17d8102e15bc9b50b126b18bc55
https://doi.org/10.1016/s0040-4039(00)80554-7
https://doi.org/10.1016/s0040-4039(00)80554-7
Autor:
Takeshi Nakai, Ei-ichi Nakai
Publikováno v:
Tetrahedron Letters. 29:5409-5412
A novel [2,3]Wittig variant, termed “siloxy-[2,3]Wittig rearrangement”, has been developed which provides the half-silylated 1,2-diol systems with a high anti-diastereoselectivity. The unusual anti-selectivity is discussed on mechanistic grounds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba6a450975d0c6942e9599e7860b888a
https://doi.org/10.1016/s0040-4039(00)82881-6
https://doi.org/10.1016/s0040-4039(00)82881-6
Publikováno v:
General Pharmacology: The Vascular System. 15:247-250
1. 1. Hg 2+ (0.005-0.5 mM) induced a concentration-dependent reduction on high-K + -induced contraction of taenia coli. 2. 2. The K + -induced increase in 45 Ca uptake was significantly reduced in the presence of Hg 2+ (0.05-0.5 mM). 3. 3. The contra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98de568bfa7d0f4b5dc4702d45c0141
https://doi.org/10.1016/0306-3623(84)90168-x
https://doi.org/10.1016/0306-3623(84)90168-x
Autor:
Ei-Ichi Nakai
Publikováno v:
Japanese journal of leprosy. 51:17-21
The India centre of JALMA (Japan Leprosy Mission for Asia) was established at Agra in 1965. At the beginning of 1966, it opened one out patient clinic at Ghatampur village near to Kanpur which is one of the famous industrial cities in India. Patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c88d8e5e1b4e01599adbca9ac26fa494
https://doi.org/10.5025/hansen1977.51.17
https://doi.org/10.5025/hansen1977.51.17
Autor:
Ei-ichi Nakai, Takeshi Nakai
Publikováno v:
ChemInform. 20
A novel [2,3]Wittig variant, termed “siloxy-[2,3]Wittig rearrangement”, has been developed which provides the half-silylated 1,2-diol systems with a high anti-diastereoselectivity. The unusual anti-selectivity is discussed on mechanistic grounds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cea0f6f15d5865eaded6a43ebdbfecda
https://doi.org/10.1002/chin.198923082
https://doi.org/10.1002/chin.198923082