Endocytosis provides a major alternative pathway for lysosomal biogenesis in kidney proximal tubular cells

Autor: Thomas Te Willnow, Christian Jacobsen, Pierre J. Courtoy, Wânia Rezende Lima, Olivier Devuyst, Erik Ei Christensen, Michel Jadot, Rikke Nielsen, Geneviève Dom

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, no. 13, p. 5407-12 (2007)

Recruitment of acid hydrolases to lysosomes generally occurs by intracellular sorting based on recognition of a common mannose 6-phosphate signal in the transGolgi network and selective transport to late endosomes/lysosomes. Here we provide evidence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3cea3f2edfed758d8db54f16d584f9b
https://researchportal.unamur.be/en/publications/1eefb80e-48cd-4d05-adbd-5721d4498d53

The European renal genome project: An integrated approach towards understanding the genetics of kidney development and disease

Autor: Nd Hastie, Andreas Schedl, Ic Meij, Rd Cox, Donald J. Davidson, G Eichele, Pj Verroust, Aw Brändli, Olivier Devuyst, Te Willnow, Ei Christensen, Jamie A. Davies, Corinne Antignac

Publikováno v: Scopus-Elsevier
Organogenesis
ResearcherID

Rapid progress in genome research creates a wealth of information on the functional annotation of mammalian genome sequences. However, as we accumulate large amounts of scientific information we are facing problems of how to integrate and relate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf8cfd43fd11515dd94c29e1740d0b0
http://www.scopus.com/inward/record.url?eid=2-s2.0-33645008518&partnerID=MN8TOARS

VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney.

Autor: Rinschen MM; Scripps Center for Metabolomics, Scripps Research, La Jolla, CA 92037, USA.; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.; Department II of Internal Medicine and Center for Molecular Medicine, University of Cologne, 50937 Cologne, Germany.; Aarhus Institute for Advanced Studies, Aarhus University, 8000 Aarhus, Denmark., Harder JL; Division of Nephrology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Carter-Timofte ME; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark., Zanon Rodriguez L; Department of Anatomy, Christian-Albrechts-University Kiel, 24118 Kiel, Germany., Mirabelli C; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Demir F; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark., Kurmasheva N; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark., Ramakrishnan SK; Department of Medicine, University of Fribourg, 1700 Fribourg, Switzerland., Kunke M; Department of Anatomy, Christian-Albrechts-University Kiel, 24118 Kiel, Germany., Tan Y; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark., Billing A; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark., Dahlke E; Department of Anatomy, Christian-Albrechts-University Kiel, 24118 Kiel, Germany., Larionov AA; Department of Medicine, University of Fribourg, 1700 Fribourg, Switzerland., Bechtel-Walz W; IV Department of Medicine and Faculty of Medicine, University Medical Center Freiburg, 79110 Freiburg, Germany., Aukschun U; IV Department of Medicine and Faculty of Medicine, University Medical Center Freiburg, 79110 Freiburg, Germany., Grabbe M; IV Department of Medicine and Faculty of Medicine, University Medical Center Freiburg, 79110 Freiburg, Germany., Nielsen R; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark., Christensen EI; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark., Kretzler M; Division of Nephrology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Huber TB; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany., Wobus CE; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Olagnier D; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark., Siuzdak G; Scripps Center for Metabolomics, Scripps Research, La Jolla, CA 92037, USA., Grahammer F; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany., Theilig F; Department of Anatomy, Christian-Albrechts-University Kiel, 24118 Kiel, Germany.; Department of Medicine, University of Fribourg, 1700 Fribourg, Switzerland.

Publikováno v: Science signaling [Sci Signal] 2022 Nov 29; Vol. 15 (762), pp. eabo7940. Date of Electronic Publication: 2022 Nov 29.

Obesity-Related Glomerulopathy: Hyperfiltration May Contribute to Early Proteinuria.

Autor: Edwards A; Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA., Christensen EI; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Unwin RJ; Department of Renal Medicine, Royal Free Campus, University College London, London, UK., Norden AGW; Department of Renal Medicine, Royal Free Campus, University College London, London, UK.

Publikováno v: Kidney international reports [Kidney Int Rep] 2021 Jan 29; Vol. 6 (3), pp. 867. Date of Electronic Publication: 2021 Jan 29 (Print Publication: 2021).

Beyond the tubule: pathological variants of LRP2 , encoding the megalin receptor, result in glomerular loss and early progressive chronic kidney disease.

Autor: Charlton JR; Division of Nephrology, Department of Pediatrics, University of Virginia, Charlottesville, Virginia., Tan W; Division of Nephrology, Massachusetts General Hospital for Children, Boston, Massachusetts., Daouk G; Division of Nephrology, Massachusetts General Hospital for Children, Boston, Massachusetts., Teot L; Department of Pathology, Boston Children's Hospital, Boston, Massachusetts., Rosen S; Department of Pathology, Boston Children's Hospital, Boston, Massachusetts.; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Bennett KM; Department of Radiology, Washington University in Saint Louis, St. Louis, Missouri., Cwiek A; Division of Nephrology, Department of Pediatrics, University of Virginia, Charlottesville, Virginia., Nam S; Department of Physics, University of Hawai'i at Manoa, Manoa, Hawai'i., Emma F; Division of Nephrology, Department of Pediatric Subspecialties, Bambino Gesù Children's Hospital- Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy., Jouret F; Groupe Interdisciplinaire de Génoprotéomique Appliquée, Unit of Cardiovascular Sciences, University of Liège, Liège, Belgium., Oliveira JP; Service of Medical Genetics, São João University Hospital Centre and Faculty of Medicine, University of Porto and i3S-Institute for Health Research and Innovation, Porto, Portugal., Tranebjærg L; Department of Clinical Genetics, Rigshospitalet/The Kennedy Centre, Copenhagen, Denmark.; Institute of Clinical Medicine, University of Copenhagen, The Panum Institute, Copenhagen, Denmark., Frykholm C; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Mane S; Department of Genetics, Yale University School of Medicine, New Haven, Connecticut., Hildebrandt F; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Srivastava T; Children's Mercy Hospital, Kansas City, Missouri., Storm T; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Christensen EI; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Nielsen R; Department of Biomedicine, Aarhus University, Aarhus, Denmark.

Publikováno v: American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2020 Dec 01; Vol. 319 (6), pp. F988-F999. Date of Electronic Publication: 2020 Oct 26.