Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ehud Schreiber"'
Autor:
Sophine B Krintel, Laurent Essioux, Assaf Wool, Julia S Johansen, Ehud Schreiber, Tomer Zekharya, Pinchas Akiva, Mikkel Ostergaard, Merete L Hetland
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38539 (2012)
BackgroundTNFα inhibitor therapy has greatly improved the treatment of patients with rheumatoid arthritis, however at least 30% do not respond. We aimed to investigate insertions and deletions (INDELS) associated with response to TNFα inhibitors in
Externí odkaz:
https://doaj.org/article/945e5501aed1486d9b0f461d734cf69c
Publikováno v:
Journal of Chemical Information and Modeling. 52:678-685
Target-oriented substructure-based virtual screening (sSBVS) of molecules is a promising approach in drug discovery. Yet, there are doubts whether sSBVS is suitable also for extrapolation, that is, for detecting molecules that are very different from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ace37401ce6331cfe0872129fe5b4f
https://doi.org/10.1021/ci200472s
https://doi.org/10.1021/ci200472s
Publikováno v:
ISRN Computational Biology.
Molecular dynamic simulations are used for investigating various aspects of biological processes. Such simulations often require intensive computer power; therefore several solutions were developed to minimize the computer power needed, including the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a37739c3cecfc68bff321eb1935d002
Autor:
Julia S. Johansen, Tomer Zekharya, Mikkel Østergaard, Pinchas Akiva, Laurent Essioux, Sophine B. Krintel, Ehud Schreiber, Assaf Wool, Merete Lund Hetland
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 6, p e38539 (2012)
PLoS ONE, Vol 7, Iss 6, p e38539 (2012)
BackgroundTNFα inhibitor therapy has greatly improved the treatment of patients with rheumatoid arthritis, however at least 30% do not respond. We aimed to investigate insertions and deletions (INDELS) associated with response to TNFα inhibitors in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58452515d8facce010f0fe7bf62c1d9f
https://pubmed.ncbi.nlm.nih.gov/22685579
https://pubmed.ncbi.nlm.nih.gov/22685579
Autor:
Avi Rosenberg, Dani Eshel, Ofer Levy, Zurit Levine, Anat Oren, Yossef Kliger, Yossi Cohen, Zohar Tiran, Claudia A. Nold-Petry, Itamar Borukhov, Assaf Wool, Ehud Schreiber, Haim Ashkenazy, Anat Amir, Amit Novik, Charles A. Dinarello, Amir Toporik
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 106(33)
Blocking conformational changes in biologically active proteins holds therapeutic promise. Inspired by the susceptibility of viral entry to inhibition by synthetic peptides that block the formation of helix–helix interactions in viral envelope prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f0aaef3d74d99710618e10d59fa239
https://pubmed.ncbi.nlm.nih.gov/19666568
https://pubmed.ncbi.nlm.nih.gov/19666568