Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ehsanollah Esfandiari"'
Autor:
Ehsanollah Esfandiari, Mary Chen, Glennda Smithson, Derek Blair, Helene Faessel, John Wagner, Lachy Mclean, Eric R. Fedyk
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 3, Pp 820-828 (2021)
Bruton’s tyrosine kinase (BTK) is a target for treatment of hematologic malignancies and autoimmune diseases. TAK‐020 is a highly selective covalent BTK inhibitor that inhibits both B cell receptor and fragment crystallizable receptor signaling.
Externí odkaz:
https://doaj.org/article/f77399c561284afe8c1603a678c5045f
Autor:
Emma, Guttman-Yassky, Eric L, Simpson, Kristian, Reich, Kenji, Kabashima, Ken, Igawa, Tetsuya, Suzuki, Hirotaka, Mano, Takeshi, Matsui, Ehsanollah, Esfandiari, Masutaka, Furue
Publikováno v:
The Lancet. 401:204-214
OX40 is crucial for T-cell differentiation and memory induction. The anti-OX40 antibody, rocatinlimab inhibits the OX40 pathway. We evaluated the efficacy and safety of rocatinlimab in adults with moderate-to-severe atopic dermatitis.This multicentre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eff86e33c84c7e32c780b1d713346a75
https://doi.org/10.1016/s0140-6736(22)02037-2
https://doi.org/10.1016/s0140-6736(22)02037-2
Autor:
Ehsanollah Esfandiari, Hélène M. Faessel, Z. Zhao, H. Gevorkyan, Lachy McLean, K. Hanna, John A. Wagner, Eric R. Fedyk, Glennda Smithson
Publikováno v:
Saturday, 16 JUNE 2018.
Background: TAK-020 is a highly selective covalent inhibitor of the Btk enzyme. Btk is involved both in B cell receptor and FcR signaling. TAK-020 showed anti-inflammatory and disease-modifying efficacy in a rat collagen-induced arthritis model and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7b42b3faf3ac6eccc45a5c5439c9c52
https://doi.org/10.1136/annrheumdis-2018-eular.2813
https://doi.org/10.1136/annrheumdis-2018-eular.2813
Autor:
Fabio Magrini, Michael E. Weinblatt, Guy Cavet, Bing Wang, Christopher D. Kane, Olga Barbarash, Mykola Vatutin, A. Godwood, Ehsanollah Esfandiari, Iain B. McInnes, Istvan Szombati, Matthew A. Sleeman, Duncan Porter, Gerd R Burmester
Publikováno v:
Annals of the Rheumatic Diseases
Objectives Mavrilimumab, a human monoclonal antibody targeting the alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor, was evaluated in a phase 2 randomised, double-blind, placebo-controlled study to investigate efficacy a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10928d2326de50b79560b6419b378488
http://europepmc.org/articles/PMC3756523
http://europepmc.org/articles/PMC3756523
Autor:
Ehsanollah Esfandiari, Paul Atherfold, Vern C. Juel, Janice M. Massey, Emma Jones, James F. Howard, Tim Buchanan, Bryan Smith, John S. Yi, Amanda Anderson, Manisha Chopra, Jeffrey T. Guptill
An integrated understanding of therapeutic plasma exchange (TPE) effects on immunoglobulins, autoantibodies, and natural or acquired (vaccine) protective antibodies in patients with autoimmune myasthenia gravis (MG) is lacking. Prior studies measured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc118fc9356534a6c954f9daa8486e1
Autor:
Anthony P. Hollander, Moreica B. Pabbruwe, Wael Kafienah, John F Tarlton, Ehsanollah Esfandiari
Publikováno v:
Biomaterials
The integration of implanted cartilage is a major challenge for the success of tissue engineering protocols. We hypothesize that in order for effective cartilage integration to take place, matrix-free chondrocytes must be induced to migrate between t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56e4fa4c7b4ac2172341d6bd1a14232
Autor:
Ehsanollah Esfandiari, Fang-Ping Huang, Xiao-Qing Wei, Max Field, Foo Y. Liew, Iain B. McInnes, Mousa Komai-Koma, George B. M. Lindop
Publikováno v:
The Journal of Immunology. 167:5338-5347
Serum from patients with systemic lupus erythematosus (SLE) contained significantly higher concentrations of IL-18 than normal individuals. MRL/lpr mice, which develop spontaneous lupus-like autoimmune disease, also had higher serum levels of IL-18 t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36cefaa5023fadef8e3f6f47bd5299e
https://doi.org/10.4049/jimmunol.167.9.5338
https://doi.org/10.4049/jimmunol.167.9.5338
Autor:
Michael Bailey, Christopher R. Stokes, Ehsanollah Esfandiari, Timothy M. Cox, Alison R. Hayman, Martin J. Evans
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 21(9)
TRACP, a marker of osteoclasts, is also expressed by cells of the immune system. We identified a novel function for TRACP in the dendritic cell. DCs from TRACP knockout mice have impaired maturation and trigger reduced Th1 responses in vivo. We postu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6507b5a58d0ad298ad6fc1a0002b7be0
https://pubmed.ncbi.nlm.nih.gov/16939395
https://pubmed.ncbi.nlm.nih.gov/16939395
Autor:
F. Magrini, Patricia C. Ryan, A. Godwood, Ehsanollah Esfandiari, Chi-Yuan Wu, Lorin Roskos, Hong Lu, Bing Wang, X. Chen, C. Kane
Publikováno v:
Annals of the Rheumatic Diseases. 71:373.3-374
Background Mavrilimumab is a high-affinity, fully human immunoglobulin G (IgG) monoclonal antibody that selectively binds to the α subunit of GM-CSF receptor (GM-CSFRα). A Phase 2a randomized, double-blind, placebo-controlled, multiple ascending do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfec0dbe9725c124e2b317c9f5d44bd2
https://doi.org/10.1136/annrheumdis-2012-eular.2639
https://doi.org/10.1136/annrheumdis-2012-eular.2639