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pro vyhledávání: '"Ehsani, Sepehr"'
Autor:
Ehsani, Sepehr
Publikováno v:
Biol. Direct 15 (2020) 19
The spike glycoprotein of the SARS-CoV-2 virus, which causes COVID-19, has attracted attention for its vaccine potential and binding capacity to host cell surface receptors. Much of this research focus has centered on the ectodomain of the spike prot
Externí odkaz:
http://arxiv.org/abs/2003.12191
Autor:
Ehsani, Sepehr
Ever since the advent of molecular biology in the 1970s, mechanical models have become the dogma in the field, where a "true" understanding of any subject is equated to a mechanistic description. This has been to the detriment of the biomedical scien
Externí odkaz:
http://arxiv.org/abs/1905.10916
Autor:
Ehsani, Sepehr
Advances in biology have mostly relied on theories that were subsequently revised, expanded or eventually refuted using experimental and other means. Theoretical biology used to primarily provide a basis to rationally examine the frameworks within wh
Externí odkaz:
http://arxiv.org/abs/1605.00033
Autor:
Ehsani, Sepehr
The cellular prion protein (PrPC) is unique amongst mammalian proteins in that it not only has the capacity to aggregate (in the form of scrapie PrP; PrPSc) and cause neuronal degeneration, but can also act as an independent vector for the transmissi
Externí odkaz:
http://hdl.handle.net/1807/33986
Autor:
Ehsani, Sepehr
Human {\alpha}-synuclein (SNCA) is a 140-amino-acid protein belonging to the three-member synuclein family. It has been extensively studied due to its misfolding/aggregation in and genetic linkage to neurodegenerative diseases, especially Parkinson's
Externí odkaz:
http://arxiv.org/abs/1505.03196
Autor:
Ehsani, Sepehr
The advent of molecular biology has led to the identification of definitive causative factors for a number of diseases, most of which are monogenic. Causes for most common diseases across the population, however, seem elusive and cannot be pinpointed
Externí odkaz:
http://arxiv.org/abs/1310.0507
Autor:
Ehsani, Sepehr
The central dogma of molecular biology, formulated more than five decades ago, compartmentalized information exchange in the cell into the DNA, RNA and protein domains. This formalization has served as an implicit thematic distinguisher for cell biol
Externí odkaz:
http://arxiv.org/abs/1301.2397
Autor:
Ehsani, Sepehr
All cells must keep time to consistently perform vital biological functions. To that end, the coupling and interrelatedness of diverse subsecond events in the complex cellular environment, such as protein folding or translation rates, cannot simply r
Externí odkaz:
http://arxiv.org/abs/1210.0168
Autor:
Ehsani, Sepehr
Many open problems in biology, as in the physical sciences, display nonlinear and 'chaotic' dynamics, which, to the extent possible, cannot be reasonably understood. Moreover, mathematical models which aim to predict/estimate unknown aspects of a bio
Externí odkaz:
http://arxiv.org/abs/1206.5557