Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ehsan Tavassoli"'
Autor:
Gerardo A Morfini, Daryl A Bosco, Hannah Brown, Rodolfo Gatto, Agnieszka Kaminska, Yuyu Song, Linda Molla, Lisa Baker, M Natalia Marangoni, Sarah Berth, Ehsan Tavassoli, Carolina Bagnato, Ashutosh Tiwari, Lawrence J Hayward, Gustavo F Pigino, D Martin Watterson, Chun-Fang Huang, Gary Banker, Robert H Brown, Scott T Brady
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65235 (2013)
Dying-back degeneration of motor neuron axons represents an established feature of familial amyotrophic lateral sclerosis (FALS) associated with superoxide dismutase 1 (SOD1) mutations, but axon-autonomous effects of pathogenic SOD1 remained undefine
Externí odkaz:
https://doaj.org/article/c19ff8f0c04447fd912d1b2f9f9ca560
Autor:
Jeffrey H. Kordower, Richard L. Magin, Ehsan Tavassoli, Gerardo Morfini, Rodolfo G. Gatto, Andrea Buenaventura, Scott T. Brady, Allen Q. Ye, Yaping Chu, Steven D. Price
Publikováno v:
Human molecular genetics. 24(18)
Cumulative evidence indicates that the onset and severity of Huntington's disease (HD) symptoms correlate with connectivity deficits involving specific neuronal populations within cortical and basal ganglia circuits. Brain imaging studies and patholo
Autor:
Vaishali Sinha, Isaac T. Schiefer, Gregory R. J. Thatcher, Mauro Fa, Robert A. Scism, Michael Brunsteiner, R. Esala P. Chandrasena, Vladislav A. Litosh, Subhasish Tapadar, Ehsan Tavassoli, Gihani T. Wijewickrama, Marton I. Siklos, Ottavio Arancio, Pavel A. Petukhov
Publikováno v:
Journal of medicinal chemistry. 56(15)
Hyperactivation of the calcium-dependent cysteine protease calpain 1 (Cal1) is implicated as a primary or secondary pathological event in a wide range of illnesses and in neurodegenerative states, including Alzheimer's disease (AD). E-64 is an epoxid
Autor:
Lawren, Vandevrede, Ehsan, Tavassoli, Jia, Luo, Zhihui, Qin, Lan, Yue, David R, Pepperberg, Gregory R, Thatcher
Publikováno v:
British journal of pharmacology. 171(2)
Chlormethiazole (CMZ), a clinical sedative/anxiolytic agent, did not reach clinical efficacy in stroke trials despite neuroprotection demonstrated in numerous animal models. Using CMZ as a lead compound, neuroprotective methiazole (MZ) analogues were
Autor:
Ehsan Tavassoli, Jia Luo, Zhihui Qin, Ottavio Arancio, Lawren VandeVrede, Gregory R. J. Thatcher, Mauro Fa, Andrew F. Teich
Learning and memory deficits in Alzheimer’s disease (AD) result from synaptic failure and neuronal loss, the latter caused in part by excitotoxicity and oxidative stress. A therapeutic approach is described, which uses NO-chimeras directed at resto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a0dc109c567c011e6a11e37bac1dac
Autor:
Ramy E. Abdelhamid, Yue-Ting Wang, Min Li, SO Abdul-Hay, Rezene T. Asghodom, Ehsan Tavassoli, Jia Luo, Gregory R. J. Thatcher, Isaac T. Schiefer, Bradley T. Michalsen, R. Esala P. Chandrasena
Hybrid nitrate drugs have been reported to provide NO bioactivity to ameliorate side effects or to provide ancillary therapeutic activity. Hybrid nitrate selective serotonin reuptake inhibitors (NO-SSRIs) were prepared to improve the therapeutic prof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eee6fb21c0ecd9f18e39900dba826e9
https://europepmc.org/articles/PMC3171965/
https://europepmc.org/articles/PMC3171965/
Autor:
M. Natalia Marangoni, Agnieszka Kaminska, Yuyu Song, Scott T. Brady, Ehsan Tavassoli, Sarah H. Berth, Rodolfo G. Gatto, Daryl A. Bosco, Ashutosh Tiwari, Robert H. Brown, Chun Fang Huang, Carolina Bagnato, Lisa Baker, D. Martin Watterson, Gerardo Morfini, Hannah E. Brown, Gustavo Pigino, Gary Banker, Linda Molla, Lawrence J. Hayward
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 6, p e65235 (2013)
PLoS ONE, Vol 8, Iss 6, p e65235 (2013)
Dying-back degeneration of motor neuron axons represents an established feature of familial amyotrophic lateral sclerosis (FALS) associated with superoxide dismutase 1 (SOD1) mutations, but axon-autonomous effects of pathogenic SOD1 remained undefine
Autor:
Ehsan Tavassoli, Manel Ben Aissa, David R. Pepperberg, Sue H. Lee, Zhihui Qin, Sujeewa C. Piyankarage, Ottavio Arancio, Lan Yue, Jia Luo, Lawren VandeVrede, Mauro Fa, Rezene T. Asghodom, Gregory R. J. Thatcher
Publikováno v:
BMC Neuroscience
Background Synaptic dysfunction is a key event in pathogenesis of neurodegenerative diseases such as Alzheimer’s disease (AD) where synapse loss pathologically correlates with cognitive decline and dementia. Although evidence suggests that aberrant