Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Ehsan Malek"'
Autor:
Ehsan Malek, Priyanka S. Rana, Muthulekha Swamydas, Michael Daunov, Masaru Miyagi, Elena Murphy, James J. Ignatz-Hoover, Leland Metheny, Seong Jin Kim, James J. Driscoll
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Functional blockade of the transforming growth factor-beta (TGFβ) signalling pathway improves the efficacy of cytotoxic and immunotherapies. Here, we conducted a phase 1b study (ClinicalTrials.gov., NCT03143985) to determine the primary end
Externí odkaz:
https://doaj.org/article/2986c29d1e41419b91ddff1528ad8605
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-17 (2022)
Abstract Multiple myeloma is an incurable cancer characterized by the uncontrolled growth of malignant plasma cells nurtured within a permissive bone marrow microenvironment. While patients mount numerous adaptive immune responses directed against th
Externí odkaz:
https://doaj.org/article/283eab1ea8d14ef384b8795692d76d60
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-20 (2021)
Abstract The TGF-β signaling pathway governs key cellular processes under physiologic conditions and is deregulated in many pathologies, including cancer. TGF-β is a multifunctional cytokine that acts in a cell- and context-dependent manner as a tu
Externí odkaz:
https://doaj.org/article/afba89148a4e4632b3b724c4d1fd6e49
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells, which typically evolves over time from its precursor, monoclonal gammopathy of undetermined significance. While the underlying mechanisms of this evolution remain elusiv
Externí odkaz:
https://doaj.org/article/7f9e1a28197f42988e9d24cd4f1fb661
Publikováno v:
Case Reports in Hematology, Vol 2018 (2018)
Great strides have been made in the treatment of acute myeloid leukemia (AML) resulting in increased number of survivors over all age groups, but especially in patients of reproductive age. Given the gonadotoxicity of high-dose induction chemotherapy
Externí odkaz:
https://doaj.org/article/98d6d72468fe4b83aebe1cdc6728b06e
Publikováno v:
Frontiers in Oncology, Vol 7 (2017)
Multiple myeloma (MM) cure remains elusive despite the availability of newer anti-myeloma agents. Patients with high-risk disease often suffer from early relapse and short survival. Allogeneic hematopoietic cell transplantation (allo-HCT) is an “im
Externí odkaz:
https://doaj.org/article/b4020bbe62584a8db699ec3c21bd02f6
Autor:
Leland Metheny, Ronald M. Sobecks, Christina Cho, Jiasheng Wang, Lisa Ciarrone, Paolo F. Caimi, Folashade Otegbeye, Brenda W. Cooper, Molly Gallogly, Ehsan Malek, Aaron T. Gerds, Betty K. Hamilton, Sergio A Giralt, Miguel-Angel Perales, Marcos J.G. de Lima
Publikováno v:
Blood. 140:1887-1889
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d27cab315696208dc6b8c94298a8f9b
https://doi.org/10.1182/blood-2022-169935
https://doi.org/10.1182/blood-2022-169935
Autor:
Naveed Ali, Hannah Schmikla, Rishil Chopra, George Brown, Pingfu Fu, Shufen Cao, James Driscoll, Gayathri Ravi, Willem Van Heeckeren, Ehsan Malek
Publikováno v:
BMJ supportivepalliative care.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d524ff6fcfd3e4bfc413bef6b706fe26
https://pubmed.ncbi.nlm.nih.gov/36410944
https://pubmed.ncbi.nlm.nih.gov/36410944
Autor:
Ehsan Malek, Jeries Kort, Leland Metheny, Pingfu Fu, Gen Li, Parameswaran Hari, Yvonne Efebera, Muzaffar H. Qazilbash, Sergio Giralt, Amrita Krishnan, Edward A. Stadtmauer, Hillard Lazarus
Publikováno v:
Transplantation and Cellular Therapy. 29:S399-S400
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d25560af8dd32409c5b8c4391f238953
https://doi.org/10.1016/s2666-6367(23)00601-2
https://doi.org/10.1016/s2666-6367(23)00601-2
Autor:
Giulia Cheloni, Dimitra Karagkouni, Daniela Torres, David J. Chung, Nina Shah, Natalie S. Callander, Thinle Chodon, Yvonne Efebera, Nancy Geller, Peiman Hematti, Hillard Lazarus, Ehsan Malek, Philip L. McCarthy, Ajay K. Nooka, Jacalyn Rosenblatt, Aaron P. Rapoport, Robert J. Soiffer, Dina Stroopinsky, Edmund K. Waller, Marcelo C. Pasquini, Ioannis Vlachos, David Avigan
Publikováno v:
Cancer Research. 83:6785-6785
Introduction: Multiple myeloma (MM), a clonal disorder of terminally differentiated plasma cells, is the second most common hematologic malignancy with ~57.9% 5-year survival rate. Current MM therapies are not curative and in most patients MM relapse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4f17560c3be3857fe29eba2ef963d12
https://doi.org/10.1158/1538-7445.am2023-6785
https://doi.org/10.1158/1538-7445.am2023-6785