Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Ehsan Ghorani"'
What is the optimal duration, dose and frequency for anti-PD1 therapy of non-small cell lung cancer?
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 15 (2023)
Over the past decade, immune checkpoint inhibitors (ICIs) have transformed the management of multiple malignancies including lung cancer. However, the optimal use of these agents in terms of duration, dose and administration frequency remains unknown
Externí odkaz:
https://doaj.org/article/a5a62f90e4e941adb3cf3b468bbe74f3
Autor:
Geoffrey J. Maher, Rosemary A. Fisher, Baljeet Kaur, Xianne Aguiar, Preetha Aravind, Natashia Cedeno, James Clark, Debbie Damon, Ehsan Ghorani, Adam Januszewski, Foteini Kalofonou, Ravindhi Murphy, Rajat Roy, Naveed Sarwar, Mark R. Openshaw, Michael J. Seckl
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-8 (2022)
Abstract Tumours expressing human chorionic gonadotropin (hCG), the majority of which are difficult to biopsy due to their vascularity, have disparate prognoses depending on their origin. As optimal management relies on accurate diagnosis, we aimed t
Externí odkaz:
https://doaj.org/article/4537b0fad97f47fca2fad90941d4c7aa
Autor:
Evelyn Menares, Felipe Gálvez-Cancino, Pablo Cáceres-Morgado, Ehsan Ghorani, Ernesto López, Ximena Díaz, Juan Saavedra-Almarza, Diego A. Figueroa, Eduardo Roa, Sergio A. Quezada, Alvaro Lladser
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Immunotherapy can induce antigen spreading of antitumor T cell response, which correlates with better outcomes. Here the authors show that tissue-resident memory CD8 T cells promote antigen spreading via lysing tumor cells and promoting their uptake
Externí odkaz:
https://doaj.org/article/49f2d80358fe4866a63b0347f802f6e7
Autor:
Ankur Chakravarthy, Andrew Furness, Kroopa Joshi, Ehsan Ghorani, Kirsty Ford, Matthew J. Ward, Emma V. King, Matt Lechner, Teresa Marafioti, Sergio A. Quezada, Gareth J. Thomas, Andrew Feber, Tim R. Fenton
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Determining the extent of immune cell infiltration into solid tumours is essential for adequate therapeutic response. Here the authors develop a DNA methylation-based approach for tumour cell fraction deconvolution and analyse tumour composition and
Externí odkaz:
https://doaj.org/article/e1cf9d7772ff44b4a8372f27b4755fbd
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Tumours employ a variety of strategies to induce immune suppression. Here the authors show that cancer-associated fibroblasts process and cross-present tumour-antigens to T-cells resulting in antigen-specific T cell death and dysfunction via upregula
Externí odkaz:
https://doaj.org/article/b48c058284114b0fae05f95b3bfc6c35
Autor:
Ankur Chakravarthy, Andrew Furness, Kroopa Joshi, Ehsan Ghorani, Kirsty Ford, Matthew J. Ward, Emma V. King, Matt Lechner, Teresa Marafioti, Sergio A. Quezada, Gareth J. Thomas, Andrew Feber, Tim R. Fenton
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
The original version of this Article contained an error in Figure 4. In panel a, the colour code for hot and cold clusters was inadvertently inverted. In the correct version of panel a, the hot clusters are blue and the cold clusters are yellow. This
Externí odkaz:
https://doaj.org/article/30b4b25d976f429294f6be5ad9bb68be
Autor:
Ehsan Ghorani, Matteo Quartagno, Fiona Blackhall, Duncan C Gilbert, Mary O'Brien, Christian Ottensmeier, Elena Pizzo, James Spicer, Alex Williams, Philip Badman, Mahesh K B Parmar, Michael J Seckl
Publikováno v:
The Lancet Oncology. 24:e219-e227
Publikováno v:
International Journal of Gynecologic Cancer. 33:414-419
The discovery that anti-programmed death-1 antibody (anti-PD-1) immunotherapy can cure patients with multidrug-resistant gestational trophoblastic neoplasia provides a new powerful and low toxicity treatment. This heralds an era within which the majo
Autor:
Chen Qing, Ehsan Ghorani
Publikováno v:
Immunity. 56:6-8
Autor:
Kwee L. Yong, Sergio A. Quezada, Javier Herrero, Martin Pule, Manuel Rodriguez-Justo, Anthony Brooks, Dominic Patel, Oliver C. Cohen, Dunnya De-Silva, Huw Richards, Selina J. Chavda, Andrew J.S. Furness, Daria Galas-Filipowicz, Melody Chin, Lucia Conde, Jake Y. Henry, Ehsan Ghorani, Lydia Lee, Nouf Alrasheed
Purpose:Immune dysregulation is described in multiple myeloma. While preclinical models suggest a role for altered T-cell immunity in disease progression, the contribution of immune dysfunction to clinical outcomes remains unclear. We aimed to charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ae590a362cc2c1903d91f6a3589fbc
https://doi.org/10.1158/1078-0432.c.6528762.v1
https://doi.org/10.1158/1078-0432.c.6528762.v1