Reduction of liver fibrosis by rationally designed macromolecular telmisartan prodrugs.

Autor: Golder MR; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Liu J; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; XTuit Pharmaceuticals, Waltham, MA, USA., Andersen JN; XTuit Pharmaceuticals, Waltham, MA, USA., Shipitsin MV; XTuit Pharmaceuticals, Waltham, MA, USA., Vohidov F; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Nguyen HV; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Ehrlich DC; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Huh SJ; XTuit Pharmaceuticals, Waltham, MA, USA., Vangamudi B; XTuit Pharmaceuticals, Waltham, MA, USA., Economides KD; XTuit Pharmaceuticals, Waltham, MA, USA., Neenan AM; XTuit Pharmaceuticals, Waltham, MA, USA., Ackley JC; XTuit Pharmaceuticals, Waltham, MA, USA., Baddour J; XTuit Pharmaceuticals, Waltham, MA, USA., Paramasivan S; XTuit Pharmaceuticals, Waltham, MA, USA., Brady SW; XTuit Pharmaceuticals, Waltham, MA, USA., Held EJ; XTuit Pharmaceuticals, Waltham, MA, USA., Reiter LA; XTuit Pharmaceuticals, Waltham, MA, USA., Saucier-Sawyer JK; XTuit Pharmaceuticals, Waltham, MA, USA., Kopesky PW; XTuit Pharmaceuticals, Waltham, MA, USA., Chickering DE; XTuit Pharmaceuticals, Waltham, MA, USA., Blume-Jensen P; XTuit Pharmaceuticals, Waltham, MA, USA. pblumejensen@xtuit.com.; Acrivon Therapeutics, Lab Central, Cambridge, MA, USA. pblumejensen@xtuit.com., Johnson JA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. jaj2109@mit.edu.

Publikováno v: Nature biomedical engineering [Nat Biomed Eng] 2018 Nov; Vol. 2 (11), pp. 822-830. Date of Electronic Publication: 2018 Aug 20.