Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ehrlic Lo"'
Autor:
Ehrlic Lo, Benjamin M. Cohen, Dale Vanyo, Christopher Wilbert, Darryl D. Dixon, Jason M. Stevens, Albert J. DelMonte, Andrew W. Glace, Gregory L. Beutner, Kenneth J. Fraunhoffer
Publikováno v:
Organic Process Research & Development. 23:1378-1385
The use of LiOH/H2O2 for cleavage of Evans oxazolidinones is an essential but often overlooked part of using these ubiquitous chiral auxiliaries in synthetic routes. These conditions were disclosed in the literature more than 30 years ago and have fo
Autor:
Jinyang Zhu, Ehrlic Lo, Mary F. Malley, Keming Zhu, Erqing Tang, Junying Fan, Rajendra P. Deshpande, Xinhua Qian, John Shabaker
Publikováno v:
Tetrahedron. 71:9408-9414
The development of a practical and efficient synthesis of a novel PPAR α/γ dual agonist, (S)-2-(((3-fluoro-4-methylphenoxy)carbonyl)(1-(4-((5-methyl-2-phenyloxazol-4-yl)methoxy)phenyl)ethyl) amino)acetic acid (1), is described. Development of a ste
Autor:
Rossano Lucius T, Michael A. Schmidt, Vu Chi Truc, Jacob Albrecht, Andrew G. Lee, Xinhua Qian, Ehrlic Lo, Steven L. Goldberg, Emily A. Reiff, Jaan A. Pesti, Chao Hang, Kenneth J. Natalie, Animesh Goswami, Zhiwei Guo, Chenchi Wang
Publikováno v:
Organic Process Research & Development. 19:1317-1322
The process development and large scale synthesis for the β-hydroxyamino amide 1 is described. The route evolved from a multistep sequence utilizing a classical resolution to a two-step enantioselective process involving an enzyme-catalyzed aldol re
Autor:
Zhiwei Guo, Animesh Goswami, Steven L. Goldberg, Kenneth J. Natalie, Vu Chi Truc, Chao Hang, Rossano Lucius T, Michael A. Schmidt, Andrew G. Lee, Ehrlic Lo, Yeung Y. Chan
Publikováno v:
Organic Process Research & Development. 19:1308-1316
The chiral β-hydroxy-α-amino acid, (2R,3S)-2-amino-3-hydroxy-3-(pyridin-4-yl)-propanoic acid, is a key intermediate in the synthesis of the API (2R,3S)-2-amino-3-hydroxy-3-(pyridin-4-yl)-1-(pyrrolidin-1-yl)propan-1-one, a developmental drug candida
Autor:
Richard Doyle, Robert M. Johnston, Wei Ding, Yeoun jin Kim, Changhong Wan, Yeung Y. Chan, Mian Gao, Olav Lyngberg, James William Bryson, Deepa Calambur, Mark R. Witmer, Stanley R. Krystek, Ronald L. Hanson, Ehrlic Lo, Steven H. Chan, Animesh Goswami, Nuria de Mas, Steven L. Goldberg, Antonio Ramirez
Publikováno v:
Bioconjugate chemistry. 27(5)
A disulfide-bridged peptide drug development candidate contained two oligopeptide chains with 11 and 12 natural amino acids joined by a disulfide bond at the N-terminal end. An efficient biotechnology based process for the production of the disulfide
Autor:
Wendel W. Doubleday, Srinivas Tummala, Simon Leung, Susanne Kiau, Konstantinos Dambalas, Alaric J. Dyckman, Stephen T. Wrobleski, Luca Parlanti, Ehrlic Lo, Hong Wu, Katerina Leftheris, John Hynes, Paul C. Lobben, Zhongping Shi, Robert P. Discordia
Publikováno v:
Organic Process Research & Development. 16:1618-1625
The development of a practical synthesis for a p38 kinase inhibitor is described. The key advances include an improved route to the key intermediate, a substituted pyrrole, and a subsequent animation utilizing O-(4-nitrobenzoyl)hydroxylamine, which p
Publikováno v:
Organic Process Research & Development. 16:102-108
This case-study outlines the development and scale-up of a novel solvent-mediated process for producing small crystals. The process combines polymorph transformation with high shear to produce API ...
Autor:
Jun Li, Qi Gao, Ehrlic Lo, Alan Braem, Monica A. Fitzgerald, Frederic G. Buono, Zerene A. Manaloto, Alicia Ng, Richard A. Hartz, David K. Leahy, Chiajen Lai, Jason Zhu, Nuria de Mas, William Merkl, Justin B. Sausker, Bao-Ning Su
Publikováno v:
Organic Process Research & Development. 14:1221-1228
BMS-764459 (1) and BMS-763534 (2) are CRF1 antagonists for the treatment of neurological disorders such as depression and anxiety. An efficient synthesis of 1 and 2 is described, which features an efficient palladium-catalyzed cyanation of a 5-chloro
Publikováno v:
Organic Process Research & Development; Jan2012, Vol. 16 Issue 1, p102-108, 7p