Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials.

Autor: Rivellese F; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK; Barts Health NHS Trust and Barts Biomedical Research Centre, National Institute for Health and Care Research (NIHR), London, UK., Nerviani A; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK; Barts Health NHS Trust and Barts Biomedical Research Centre, National Institute for Health and Care Research (NIHR), London, UK., Giorli G; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK., Warren L; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK., Jaworska E; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK., Bombardieri M; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK; Barts Health NHS Trust and Barts Biomedical Research Centre, National Institute for Health and Care Research (NIHR), London, UK., Lewis MJ; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK; Barts Health NHS Trust and Barts Biomedical Research Centre, National Institute for Health and Care Research (NIHR), London, UK., Humby F; Barts Health NHS Trust and Barts Biomedical Research Centre, National Institute for Health and Care Research (NIHR), London, UK; Rheumatology Department, Guy's and St Thomas' NHS Foundation Trust, London, UK., Pratt AG; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK; Directorate of Musculoskeletal Services, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Filer A; Rheumatology Research Group, Institute for Inflammation and Ageing, NIHR Birmingham Biomedical Research Centre and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK., Gendi N; Basildon University Hospital, Basildon and Thurrock University NHS Hospitals Foundation Trust, Basildon, UK., Cauli A; Rheumatology Unit, AOU and University of Cagliari, Monserrato, Italy; UOC of Radiology, Ospedale SS Trinità, ATS Cagliari, Italy., Choy E; CREATE Centre, Cardiff University, Cardiff, UK; Department of Rheumatology, University Hospital of Wales, Cardiff, UK., McInnes I; Glasgow Clinical Research Facility, Glasgow Royal Infirmary, Glasgow, UK., Durez P; Institute of Experimental and Clinical Research, Université Catholique de Louvain, Brussels, Belgium; Department of Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium., Edwards CJ; NIHR Southampton Clinical Research Facility, University Hospital Southampton, Southampton, UK; Faculty of Medicine, University of Southampton, Southampton, UK., Buch MH; Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK; NIHR Manchester Biomedical Research Centre, Manchester, UK., Gremese E; Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Taylor PC; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK., Ng N; Rheumatology Department, Guy's and St Thomas' NHS Foundation Trust, London, UK., Cañete JD; Rheumatology Department, Hospital Clínic de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pí I Sunyer, Barcelona, Spain., Raizada S; New Cross Hospital and Cannock Chase Hospital, Royal Wolverhampton NHS Trust, Wolverhampton, UK., McKay ND; Edinburgh Rheumatology Research Group and Rheumatic Diseases Unit, NHS Lothian, Edinburgh, UK., Jadon D; Department of Medicine, University of Cambridge, Cambridge, UK., Sainaghi PP; Department of Rheumatology, University Eastern Piedmont and Maggiore della Carita Hospital, Novara, Italy., Stratton R; Royal Free Hospital, Royal Free London NHS Foundation Trust, London, UK., Ehrenstein MR; Department of Rheumatology, University College London, London, UK., Ho P; The Kellgren Centre for Rheumatology, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, UK., Pereira JP; Rheumatology Department, Hospital De Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal; Rheumatology Research Unit, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Dasgupta B; Rheumatology Department, Mid and South Essex University Hospitals NHS Foundation Trust, Southend University Hospital, Westcliff-on-Sea, UK., Gorman C; Department of Rheumatology, Homerton University Hospital, Homerton Healthcare NHS Foundation Trust, London, UK., Galloway J; King's College Hospital, King's College Hospital NHS Foundation Trust, London, UK., Chinoy H; Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK; Department of Rheumatology, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Science Centre, Salford, UK., van der Heijde D; Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands., Sasieni P; King's Clinical Trials Unit, Kings College London, London, UK., Barton A; Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Pitzalis C; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK; Barts Health NHS Trust and Barts Biomedical Research Centre, National Institute for Health and Care Research (NIHR), London, UK; IRCCS Humanitas Research Hospital, Milan, Italy. Electronic address: c.pitzalis@qmul.ac.uk.

Publikováno v: The Lancet. Rheumatology [Lancet Rheumatol] 2023 Nov; Vol. 5 (11), pp. e648-e659.

SLE is not a one-size-fits-all disease.

Autor: Ehrenstein MR; Department of Rheumatology, University College London , London, UK., Shipa M; Department of Rheumatology, University College London , London, UK.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2023 Jun 05; Vol. 220 (6). Date of Electronic Publication: 2023 Apr 25.

Identification of biomarkers to stratify response to B-cell-targeted therapies in systemic lupus erythematosus: an exploratory analysis of a randomised controlled trial.

Autor: Shipa M; Department of Rheumatology, University College London, London, UK., Santos LR; Department of Rheumatology, University College London, London, UK., Nguyen DX; Department of Rheumatology, University College London, London, UK., Embleton-Thirsk A; Comprehensive Clinical Trials Unit, University College London, London, UK., Parvaz M; Department of Rheumatology, University College London, London, UK., Heptinstall LL; Department of Renal Medicine, Royal Free Hospital, University College London, London, UK., Pepper RJ; Department of Renal Medicine, Royal Free Hospital, University College London, London, UK., Isenberg DA; Department of Rheumatology, University College London, London, UK., Gordon C; Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK., Ehrenstein MR; Department of Rheumatology, University College London, London, UK.

Publikováno v: The Lancet. Rheumatology [Lancet Rheumatol] 2022 Nov 28; Vol. 5 (1), pp. e24-e35. Date of Electronic Publication: 2022 Nov 28 (Print Publication: 2023).

Author Correction: A novel Streptococcus pneumoniae human challenge model demonstrates Treg lymphocyte recruitment to the infection site.

Autor: Szylar G; Centre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, Rayne Building, 5 University Street, London, WC1E 6JF, UK., Wysoczanski R; Centre for Molecular Medicine, UCL Division of Medicine, Rayne Institute, 5 University Street, London, WC1E 6JF, UK., Marshall H; Centre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, Rayne Building, 5 University Street, London, WC1E 6JF, UK., Marks DJB; Centre for Molecular Medicine, UCL Division of Medicine, Rayne Institute, 5 University Street, London, WC1E 6JF, UK., José R; Centre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, Rayne Building, 5 University Street, London, WC1E 6JF, UK., Ehrenstein MR; Centre for Rheumatology, UCL Division of Medicine, Rayne Building, 5 University Street, London, WC1E 6JF, UK., Brown JS; Centre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, Rayne Building, 5 University Street, London, WC1E 6JF, UK. jeremy.brown@ucl.ac.uk.

Publikováno v: Scientific reports [Sci Rep] 2022 Apr 05; Vol. 12 (1), pp. 5676. Date of Electronic Publication: 2022 Apr 05.

Impact of a mid-urethral synthetic mesh sling on long-term risk of systemic conditions in women with stress urinary incontinence: a national cohort study.

Autor: Muller P; London School of Hygiene & Tropical Medicine, London, UK.; Royal College of Obstetricians and Gynaecologists, London, UK., Gurol-Urganci I; London School of Hygiene & Tropical Medicine, London, UK.; Royal College of Obstetricians and Gynaecologists, London, UK., Thakar R; Royal College of Obstetricians and Gynaecologists, London, UK.; Croydon University Hospital, Croydon, UK., Ehrenstein MR; University College London, London, UK., Van Der Meulen J; London School of Hygiene & Tropical Medicine, London, UK.; Royal College of Obstetricians and Gynaecologists, London, UK., Jha S; British Society of Urogynaecology, London, UK.; Sheffield Teaching Hospitals, Sheffield, UK.

Publikováno v: BJOG : an international journal of obstetrics and gynaecology [BJOG] 2022 Mar; Vol. 129 (4), pp. 664-670. Date of Electronic Publication: 2021 Oct 05.