Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ehesan U. Sharif"'
Autor:
Dillon H. Miles, Ada Chen, Manmohan Reddy Leleti, Divyank Soni, Stephen W Young, Artur K. Mailyan, Kenneth V. Lawson, Stefan G Shaqfeh, Ehesan U. Sharif, Jenna L. Jeffrey, Jesus Banuelos, Xuelei Yan, Samuel L Drew, Kimberline Gerrick, Nigel Walker, Puja Dhanota, Lixia Jin, Jay P. Powers, Elaine Ginn, Guillaume Mata, Kent Wong, Hema Singh, Jeremy Fournier, Joel W. Beatty, Ulrike Schindler, Amber Pham, Matthew J. Walters, Jie Chen, Cesar Meleza, Xiaoning Zhao, Nell Narasappa
Publikováno v:
Journal of Medicinal Chemistry. 65:1418-1444
Phosphoinositide-3-kinase γ (PI3Kγ) is highly expressed in immune cells and promotes the production and migration of inflammatory mediators. The inhibition of PI3Kγ has been shown to repolarize the tumor immune microenvironment to a more inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37aec4464f4375ff8b99d31a40b9e89
https://doi.org/10.1021/acs.jmedchem.1c01153
https://doi.org/10.1021/acs.jmedchem.1c01153
Publikováno v:
Israel Journal of Chemistry. 61:394-400
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::709559b1a27f32d4e8145890b67550e2
https://doi.org/10.1002/ijch.202100015
https://doi.org/10.1002/ijch.202100015
Autor:
Dillon H. Miles, Nigel Walker, Manmohan Reddy Leleti, Xiaoning Zhao, Eric T. Newcomb, Kenneth V. Lawson, Jaroslaw Kalisiak, Erick Allen Lindsey, Lixia Jin, Ada Chen, Laurent Debien, Guifen Xu, Ehesan U. Sharif, Norbert Sträter, Brandon Reid Rosen, Stephen W Young, Emma Scaletti, Jay P. Powers
Publikováno v:
Journal of Medicinal Chemistry. 64:845-860
Solid tumors are often associated with high levels of extracellular ATP. Ectonucleotidases catalyze the sequential hydrolysis of ATP to adenosine, which potently suppresses T-cell and NK-cell functions via the adenosine receptors (A2a and A2b). The e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d84eb5999417f66c4c65efddd2d03a7
https://doi.org/10.1021/acs.jmedchem.0c01835
https://doi.org/10.1021/acs.jmedchem.0c01835
Autor:
Dillon H. Miles, Ada Chen, Manmohan Reddy Leleti, Divyank Soni, Stephen W Young, Artur K. Mailyan, Kenneth V. Lawson, Stefan G Shaqfeh, Ehesan U. Sharif, Pei-Yu Chen, Jenna L. Jeffrey, Jesus Banuelos, Xuelei Yan, Samuel L Drew, Nigel Walker, Puja Dhanota, Lixia Jin, Jay P. Powers, Elaine Ginn, Guillaume Mata, Kent Wong, Jeremy Fournier, Joel W. Beatty, Rhiannon Thomas-Tran, Ulrike Schindler, Amber Pham, Matthew J. Walters, Jie Chen, Cesar Meleza, Xiaoning Zhao
Publikováno v:
Journal of Medicinal Chemistry. 63:11235-11257
The selective inhibition of the lipid signaling enzyme PI3Kγ constitutes an opportunity to mediate immunosuppression and inflammation within the tumor microenvironment but is difficult to achieve due to the high sequence homology across the class I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237c477c3969b94ce636dfc76aca3e4f
https://doi.org/10.1021/acs.jmedchem.0c01203
https://doi.org/10.1021/acs.jmedchem.0c01203
Autor:
Brandon Reid Rosen, Manmohan Reddy Leleti, Ada Chen, Sharon Zhao, Jenna L. Jeffrey, Norbert Sträter, Eric T. Newcomb, Jay P. Powers, Kenneth V. Lawson, Lijuan Fu, Dillon H. Miles, Uli Schindler, Wade Berry, Stephen W Young, Tim Park, Emma Scaletti, Lixia Jin, Joanne B.L. Tan, Ehesan U. Sharif, Laurent Debien, Erick Allen Lindsey, Jaroslaw Kalisiak, Susanne Moschütz, Matthew J. Walters, Guifen Xu, Nigel Walker
Publikováno v:
Journal of Medicinal Chemistry. 63:11448-11468
Extracellular adenosine (ADO), present in high concentrations in the tumor microenvironment (TME), suppresses immune function via inhibition of T cell and NK cell activation. Intratumoral generation of ADO depends on the sequential catabolism of ATP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb2a8967687083bf528bd8c33e2866f
https://doi.org/10.1021/acs.jmedchem.0c00525
https://doi.org/10.1021/acs.jmedchem.0c00525
Autor:
Jenna L. Jeffrey, Laurent Debien, Dillon H. Miles, Manmohan Reddy Leleti, Brandon Reid Rosen, Jay P. Powers, Ehesan U. Sharif
Publikováno v:
Organic Process Research & Development. 24:1254-1261
AB928 is a potent and selective dual antagonist of the A2a and A2b receptors, which is currently in clinical trials. Here, we report the development of two scalable and practical syntheses of AB928...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89f6c9ebef3f0788b33a57e7900a3115
https://doi.org/10.1021/acs.oprd.0c00124
https://doi.org/10.1021/acs.oprd.0c00124
Publikováno v:
Chemical Science
A general method for the synthesis of cyclic α-amido-ethers containing different amide functionalities including lactams, tetramic acids, amino acids and nucleoside bases.
Efficient synthesis of versatile building blocks for enabling medicinal
Efficient synthesis of versatile building blocks for enabling medicinal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebeeb8dfecab3aac7be5d2d126ea733
https://doi.org/10.1039/c6sc02849g
https://doi.org/10.1039/c6sc02849g
Publikováno v:
Journal of the American Chemical Society. 141(26)
Pyrimidine nucleosides are an important class of compounds with versatile applications across many fields, including biology and medicinal chemistry. Synthesis of nucleoside analogs in optically pure form via traditional glycosylation has always been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2f033698ec02c7105ab48d449c530e
https://pubmed.ncbi.nlm.nih.gov/31194521
https://pubmed.ncbi.nlm.nih.gov/31194521
Publikováno v:
Chemistry – A European Journal. 22:2634-2638
The synthesis of densly functionized α-silyl-β-hydroxyl vinylsilanes via ruthenium-catalyzed multicomponent reaction (MCR) is reported herein. Exceptionally high regio- and diastereoselectivity was achieved by employing an unprecedented hydrosilyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4502ec5ca922211dab3ad359c76bb04b
https://doi.org/10.1002/chem.201504981
https://doi.org/10.1002/chem.201504981
Autor:
Ehesan U. Sharif, Jay P. Powers, Nicholas S. Chan, Dillon H. Miles, Manmohan Reddy Leleti, Brandon Reid Rosen
Publikováno v:
Tetrahedron Letters. 61:151855
A protocol for the synthesis of hindered 4-aryl 2-aminopyrimidines from β–keto esters is described. The process employs trifluoroethanol as an essential additive to promote the guanidine condensation reaction, enabling the synthesis of 25 aryl- an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d89cb42bead6f12b2fe690caa28bf58
https://doi.org/10.1016/j.tetlet.2020.151855
https://doi.org/10.1016/j.tetlet.2020.151855