Cultivation of microbial cultures at high cell density in microbioreactor fermentations to increase protein yield.

Autor: Pepeliaev S; Ipsen Bioinnovation, Abingdon, UK.; The Jenner Institute Laboratories, University of Oxford, Oxford, UK., Ehebauer MT; Ipsen Bioinnovation, Abingdon, UK.

Publikováno v: Biotechnology and applied biochemistry [Biotechnol Appl Biochem] 2023 Jun; Vol. 70 (3), pp. 1121-1127. Date of Electronic Publication: 2022 Dec 21.

Pangenome and genomic signatures linked to the dominance of the lineage-4 of Mycobacterium tuberculosis isolated from extrapulmonary tuberculosis patients in western Ethiopia.

Autor: Chekesa, Basha^1,2 (AUTHOR) balchachekesa@gmail.com, Singh, Harinder³ (AUTHOR), Gonzalez-Juarbe, Norberto³ (AUTHOR), Vashee, Sanjay³ (AUTHOR), Wiscovitch-Russo, Rosana³ (AUTHOR), Dupont, Christopher L.⁴ (AUTHOR), Girma, Musse¹ (AUTHOR), Kerro, Oudessa⁵ (AUTHOR), Gumi, Balako¹ (AUTHOR), Ameni, Gobena^1,6 (AUTHOR) balchachekesa@gmail.com

Publikováno v: PLoS ONE. 7/25/2024, Vol. 19 Issue 7, p1-23. 23p.

Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.

Autor: Quevedo CE; Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK., Cruz-Migoni A; Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxon, OX11 0FA, UK., Bery N; Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK., Miller A; Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK., Tanaka T; Leeds Institute for Molecular Medicine, St James University Hospital, Leeds, LS9 7TF, UK.; Research & Development, Sanofi K.K., Tokyo Opera City Tower, 3-20-2, Nishi Shinjuku, Shinjuku-ku, Tokyo, 163-1488, Japan., Petch D; Leeds Institute for Molecular Medicine, St James University Hospital, Leeds, LS9 7TF, UK., Bataille CJR; Chemistry Research Laboratory, 12 Mansfield Rd, Oxford, OX1 3TA, UK., Lee LYW; Domainex, Chesterford Research Park, Little Chesterford, Saffron Walden, CB10 1XL, UK., Fallon PS; Domainex, Chesterford Research Park, Little Chesterford, Saffron Walden, CB10 1XL, UK., Tulmin H; Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.; Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK., Ehebauer MT; Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.; Oxford Drug Discovery Institute, Nuffield Department of Medicine Research Building, University of Oxford, Old Road Campus, Oxford, OX3 7FZ, UK., Fernandez-Fuentes N; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxon, OX11 0FA, UK.; Institute of Biological, Environmental and Rural Sciences, University of Aberystwyth, Aberystwyth, SY23 3EB, UK., Russell AJ; Chemistry Research Laboratory, 12 Mansfield Rd, Oxford, OX1 3TA, UK., Carr SB; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxon, OX11 0FA, UK.; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK., Phillips SEV; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxon, OX11 0FA, UK.; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK., Rabbitts TH; Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK. terence.rabbitts@imm.ox.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2018 Aug 09; Vol. 9 (1), pp. 3169. Date of Electronic Publication: 2018 Aug 09.

Discovery of a PCAF Bromodomain Chemical Probe.

Autor: Moustakim M; Structural Genomics Consortium & Target Discovery Institute, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford, OX3 7DQ and OX3 7FZ, UK.; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Clark PG; Department of Chemistry, Simon Fraser University, Burnaby, V5A 1S6, Canada., Trulli L; Dipartimento di Chimica, Università degli Studi di Roma 'La Sapienza', Piazzale Aldo Moro 5, 00185, Roma, Italy., Fuentes de Arriba AL; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Ehebauer MT; ARUK Oxford Drug Discovery Institute, University of Oxford, Oxford, OX3 7FZ, UK., Chaikuad A; Johann Wolfgang Goethe-University, Institute for Pharmaceutical Chemistry and Buchmann Institute for Life Sciences, 60438, Frankfurt am Main, Germany., Murphy EJ; ARUK Oxford Drug Discovery Institute, University of Oxford, Oxford, OX3 7FZ, UK., Mendez-Johnson J; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 153611, USA., Daniels D; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 153611, USA., Hou CD; Structural Genomics Consortium, MaRS South Tower, Suite 732, 101 College Street, Toronto, Ontario, M5G 1LZ, Canada., Lin YH; Structural Genomics Consortium, MaRS South Tower, Suite 732, 101 College Street, Toronto, Ontario, M5G 1LZ, Canada., Walker JR; Structural Genomics Consortium, MaRS South Tower, Suite 732, 101 College Street, Toronto, Ontario, M5G 1LZ, Canada., Hui R; Structural Genomics Consortium, MaRS South Tower, Suite 732, 101 College Street, Toronto, Ontario, M5G 1LZ, Canada., Yang H; Nuffield Department of Medicine and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, OX3 7FZ, UK., Dorrell L; Nuffield Department of Medicine and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, OX3 7FZ, UK., Rogers CM; Structural Genomics Consortium & Target Discovery Institute, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford, OX3 7DQ and OX3 7FZ, UK., Monteiro OP; Structural Genomics Consortium & Target Discovery Institute, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford, OX3 7DQ and OX3 7FZ, UK., Fedorov O; Structural Genomics Consortium & Target Discovery Institute, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford, OX3 7DQ and OX3 7FZ, UK., Huber KV; Structural Genomics Consortium & Target Discovery Institute, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford, OX3 7DQ and OX3 7FZ, UK., Knapp S; Johann Wolfgang Goethe-University, Institute for Pharmaceutical Chemistry and Buchmann Institute for Life Sciences, 60438, Frankfurt am Main, Germany., Heer J; UCB Pharma Ltd, Slough, SL1 3WE, UK., Dixon DJ; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Brennan PE; Structural Genomics Consortium & Target Discovery Institute, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford, OX3 7DQ and OX3 7FZ, UK.; ARUK Oxford Drug Discovery Institute, University of Oxford, Oxford, OX3 7FZ, UK.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2017 Jan 16; Vol. 56 (3), pp. 827-831. Date of Electronic Publication: 2016 Dec 14.

ATP half-sites in RadA and RAD51 recombinases bind nucleotides.

Autor: Marsh ME; Department of Biochemistry University of Cambridge UK; Present address: Paul Scherrer Institut Villingen Switzerland., Scott DE; Department of Chemistry University of Cambridge UK., Ehebauer MT; Department of Biochemistry University of Cambridge UK; Present address: Target Discovery Institute Nuffield Department of Medicine University of Oxford UK., Abell C; Department of Chemistry University of Cambridge UK., Blundell TL; Department of Biochemistry University of Cambridge UK., Hyvönen M; Department of Biochemistry University of Cambridge UK.

Publikováno v: FEBS open bio [FEBS Open Bio] 2016 Apr 06; Vol. 6 (5), pp. 372-85. Date of Electronic Publication: 2016 Apr 06 (Print Publication: 2016).