Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells.

Autor: Oladapo HO; Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA., Tarpley M; Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA., Sauer SJ; Department of Surgery, Division of Surgical Sciences, Duke University School of Medicine, Durham, NC, 27710, USA., Addo KA; Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA., Ingram SM; Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA., Strepay D; Department of Biological and Biomedical Sciences, North Carolina Central University, Durham, NC, 27707, USA., Ehe BK; Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA., Chdid L; Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA., Trinkler M; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Roques JR; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Darr DB; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Fleming JM; Department of Biological and Biomedical Sciences, North Carolina Central University, Durham, NC, 27707, USA; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Devi GR; Department of Surgery, Division of Surgical Sciences, Duke University School of Medicine, Durham, NC, 27710, USA; Duke Cancer Institute, Duke University, Durham, NC 27710, USA. Electronic address: gayathri.devi@duke.edu., Williams KP; Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA; Duke Cancer Institute, Duke University, Durham, NC 27710, USA. Electronic address: kpwilliams@nccu.edu.

Publikováno v: Cancer letters [Cancer Lett] 2017 Dec 28; Vol. 411, pp. 136-149. Date of Electronic Publication: 2017 Sep 28.

Identification of a DYRK1A-mediated phosphorylation site within the nuclear localization sequence of the hedgehog transcription factor GLI1.

Autor: Ehe BK; Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC 27707, USA., Lamson DR; Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC 27707, USA., Tarpley M; Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC 27707, USA., Onyenwoke RU; Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC 27707, USA; Department of Pharmaceutical Sciences, North Carolina Central University, Durham, NC 27707, USA., Graves LM; Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA., Williams KP; Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC 27707, USA; Department of Pharmaceutical Sciences, North Carolina Central University, Durham, NC 27707, USA. Electronic address: kpwilliams@nccu.edu.

Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2017 Sep 23; Vol. 491 (3), pp. 767-772. Date of Electronic Publication: 2017 Jul 20.