Dataset for suppressors of amyloid-β toxicity and their functions in recombinant protein production in yeast

Autor: Xin Chen, Xiaowei Li, Boyang Ji, Yanyan Wang, Olena P. Ishchuk, Egor Vorontsov, Dina Petranovic, Verena Siewers, Martin K.M. Engqvist

Publikováno v: Data in Brief, Vol 42, Iss , Pp 108322- (2022)

The production of recombinant proteins at high levels often induces stress-related phenotypes by protein misfolding or aggregation. These are similar to those of the yeast Alzheimer's disease (AD) model in which amyloid-β peptides (Aβ42) were accum

Externí odkaz: https://doaj.org/article/f8a2cfb9152c4c64a1593650fa31380a

The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells

Autor: Jingjing Zhang, Manickam Gurusaran, Yasuhiro Fujiwara, Kexin Zhang, Meriem Echbarthi, Egor Vorontsov, Rui Guo, Devon F. Pendlebury, Intekhab Alam, Gabriel Livera, Martini Emmanuelle, P. Jeremy Wang, Jayakrishnan Nandakumar, Owen R. Davies, Hiroki Shibuya

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)

In meiosis, BRCA2 associates to MEILB2 localising at DNA double-strand breaks (DSBs). Here, the authors identify BRCA2 and MEILB2- associating protein 1 termed BRME1 to work together in regulating meiotic recombination.

Externí odkaz: https://doaj.org/article/6e679d2b3eb24e0c874ec41bdc538df0

Quantifying absolute gene expression profiles reveals distinct regulation of central carbon metabolism genes in yeast

Autor: Rosemary Yu, Egor Vorontsov, Carina Sihlbom, Jens Nielsen

Publikováno v: eLife, Vol 10 (2021)

In addition to controlled expression of genes by specific regulatory circuits, the abundance of proteins and transcripts can also be influenced by physiological states of the cell such as growth rate and metabolism. Here we examine the control of gen

Externí odkaz: https://doaj.org/article/37014153e3aa4a6f92926d9970109c38

Evolution of Helicobacter: Acquisition by Gastric Species of Two Histidine-Rich Proteins Essential for Colonization.

Autor: Daniel Vinella, Frédéric Fischer, Egor Vorontsov, Julien Gallaud, Christian Malosse, Valérie Michel, Christine Cavazza, Marie Robbe-Saule, Pierre Richaud, Julia Chamot-Rooke, Céline Brochier-Armanet, Hilde De Reuse

Publikováno v: PLoS Pathogens, Vol 11, Iss 12, p e1005312 (2015)

Metal acquisition and intracellular trafficking are crucial for all cells and metal ions have been recognized as virulence determinants in bacterial pathogens. Virulence of the human gastric pathogen Helicobacter pylori is dependent on nickel, cofact

Externí odkaz: https://doaj.org/article/532a2e4814d14920b1651c38d1491cb4

Optimized sample preparation and data analysis for TMT proteomic analysis of cerebrospinal fluid applied to the identification of Alzheimer’s disease biomarkers

Autor: Sophia Weiner, Mathias Sauer, Pieter Jelle Visser, Betty M. Tijms, Egor Vorontsov, Kaj Blennow, Henrik Zetterberg, Johan Gobom

Publikováno v: Weiner, S, Sauer, M, Visser, P J, Tijms, B M, Vorontsov, E, Blennow, K, Zetterberg, H & Gobom, J 2022, ' Optimized sample preparation and data analysis for TMT proteomic analysis of cerebrospinal fluid applied to the identification of Alzheimer’s disease biomarkers ', Clinical Proteomics, vol. 19, no. 1, 13 . https://doi.org/10.1186/s12014-022-09354-0
Clinical Proteomics, 19(1):13. BioMed Central Ltd.
Clinical Proteomics, 19(1):13. BioMed Central

Background Cerebrospinal fluid (CSF) is an important biofluid for biomarkers of neurodegenerative diseases such as Alzheimer’s disease (AD). By employing tandem mass tag (TMT) proteomics, thousands of proteins can be quantified simultaneously in la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ced253fec644d0b0db7f1b26deb9c0
https://research.vumc.nl/en/publications/65ca188d-9c99-4a8b-be0b-e2c5a9260e0f