Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Egor Marin"'
Autor:
Ivan S. Okhrimenko, Kirill Kovalev, Lada E. Petrovskaya, Nikolay S. Ilyinsky, Alexey A. Alekseev, Egor Marin, Tatyana I. Rokitskaya, Yuri N. Antonenko, Sergey A. Siletsky, Petr A. Popov, Yuliya A. Zagryadskaya, Dmytro V. Soloviov, Igor V. Chizhov, Dmitrii V. Zabelskii, Yury L. Ryzhykau, Alexey V. Vlasov, Alexander I. Kuklin, Andrey O. Bogorodskiy, Anatolii E. Mikhailov, Daniil V. Sidorov, Siarhei Bukhalovich, Fedor Tsybrov, Sergey Bukhdruker, Anastasiia D. Vlasova, Valentin I. Borshchevskiy, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Ernst Bamberg, Valentin I. Gordeliy
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract Proteorhodopsins (PRs), bacterial light-driven outward proton pumps comprise the first discovered and largest family of rhodopsins, they play a significant role in life on the Earth. A big remaining mystery was that up-to-date there was no d
Externí odkaz:
https://doaj.org/article/54cdf252057f4eb6991ac73b9bcc181c
Autor:
Egor Marin, Daniil A. Kornilov, Sergey S. Bukhdruker, Vladimir A. Aleksenko, Valentin A. Manuvera, Egor V. Zinovev, Kirill V. Kovalev, Mikhail B. Shevtsov, Anna A. Talyzina, Pavel A. Bobrovsky, Pavel K. Kuzmichev, Alexey V. Mishin, Ivan Y. Gushchin, Vassili N. Lazarev, Valentin I. Borshchevskiy
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Destabilase from the medical leech Hirudo medicinalis belongs to the family of i-type lysozymes. It has two different enzymatic activities: microbial cell walls destruction (muramidase activity), and dissolution of the stabilized fibrin (iso
Externí odkaz:
https://doaj.org/article/701793d976cd4342b1095bd6c97972f6
Autor:
Elizaveta Lyapina, Egor Marin, Anastasiia Gusach, Philipp Orekhov, Andrey Gerasimov, Aleksandra Luginina, Daniil Vakhrameev, Margarita Ergasheva, Margarita Kovaleva, Georgii Khusainov, Polina Khorn, Mikhail Shevtsov, Kirill Kovalev, Sergey Bukhdruker, Ivan Okhrimenko, Petr Popov, Hao Hu, Uwe Weierstall, Wei Liu, Yunje Cho, Ivan Gushchin, Andrey Rogachev, Gleb Bourenkov, Sehan Park, Gisu Park, Hyo Jung Hyun, Jaehyun Park, Valentin Gordeliy, Valentin Borshchevskiy, Alexey Mishin, Vadim Cherezov
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
S1P5 is a sphingosine-1-phosphate (S1P) receptor implicated in immune and neurodegenerative disorders. Here, authors report a crystal structure of the S1P5 receptor in complex with a selective inverse agonist, revealing an allosteric subpocket and sh
Externí odkaz:
https://doaj.org/article/36cf9a61df10484aabf068185a39d283
Autor:
Andrei Gilep, Tatsiana Varaksa, Sergey Bukhdruker, Anton Kavaleuski, Yury Ryzhykau, Sviatlana Smolskaya, Tatsiana Sushko, Kouhei Tsumoto, Irina Grabovec, Ivan Kapranov, Ivan Okhrimenko, Egor Marin, Mikhail Shevtsov, Alexey Mishin, Kirill Kovalev, Alexander Kuklin, Valentin Gordeliy, Leonid Kaluzhskiy, Oksana Gnedenko, Evgeniy Yablokov, Alexis Ivanov, Valentin Borshchevskiy, Natallia Strushkevich
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2023)
Ferredoxins are small iron–sulfur proteins and key players in essential metabolic pathways. Among all types, 3Fe–4S ferredoxins are less studied mostly due to anaerobic requirements. Their complexes with cytochrome P450 redox partners have not be
Externí odkaz:
https://doaj.org/article/6cc0066959ee4a48a08a2713d9d6501e
Autor:
Kirill Kovalev, Roman Astashkin, Ivan Gushchin, Philipp Orekhov, Dmytro Volkov, Egor Zinovev, Egor Marin, Maksim Rulev, Alexey Alekseev, Antoine Royant, Philippe Carpentier, Svetlana Vaganova, Dmitrii Zabelskii, Christian Baeken, Ilya Sergeev, Taras Balandin, Gleb Bourenkov, Xavier Carpena, Roeland Boer, Nina Maliar, Valentin Borshchevskiy, Georg Büldt, Ernst Bamberg, Valentin Gordeliy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The Na+-pumping KR2 rhodopsin from Krokinobacter eikastus is a light-driven non-proton cation pump whose mechanism of pumping remains to be understood. Here authors solved crystal structures of the O-intermediate state of the pentameric form of KR2 a
Externí odkaz:
https://doaj.org/article/c7ebae3993e6420a849c16a42789609d
Autor:
Anastasiia Gusach, Aleksandra Luginina, Egor Marin, Rebecca L. Brouillette, Élie Besserer-Offroy, Jean-Michel Longpré, Andrii Ishchenko, Petr Popov, Nilkanth Patel, Taku Fujimoto, Toru Maruyama, Benjamin Stauch, Margarita Ergasheva, Daria Romanovskaia, Anastasiia Stepko, Kirill Kovalev, Mikhail Shevtsov, Valentin Gordeliy, Gye Won Han, Vsevolod Katritch, Valentin Borshchevskiy, Philippe Sarret, Alexey Mishin, Vadim Cherezov
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Cysteinyl leukotriene G protein-coupled receptors CysLT1 and CysLT2 regulate pro-inflammatory responses associated with allergic disorders. Here, authors describe four crystal structures of CysLT2R in complex with three dual CysLT1R/CysLT2R antagonis
Externí odkaz:
https://doaj.org/article/c54160b2896f4e3f9bcd8053dc21a8c7
Autor:
Egor Marin, Daniil Vakhrameev, Anastasiia Gusach, Aleksandra Luginina, Kirill Kovalev, Wei Liu, Uwe Weierstall, Jaehun Park, Ki Hyun Nam, Cho Yunje, Alexey Mishin, Vadim Cherezov, Valentin Borshchevskiy
Publikováno v:
International Journal of Biomedicine, Vol 11, Iss Suppl_1, Pp 12-12 (2021)
Background: Membrane receptors play an important role in signal transduction across the cell membrane in all living organisms. Their structural studies have been enabled by multiple technological breakthroughs in their heterologous expression, stabil
Externí odkaz:
https://doaj.org/article/841a90d82024427a84f205a4f2d94f81
Publikováno v:
International Journal of Biomedicine, Vol 9, Iss Suppl_1, Pp S34-S35 (2019)
Background: Tuberculosis (TB), caused by pathogenic bacteria Mycobacterium tuberculosis (MTb), is known to be among top-10 causes of death worldwide. In 2019, WHO mentioned drug-resistance with special focus on drug-resistant TB as one of the top-10
Externí odkaz:
https://doaj.org/article/25d5e3fc413e4c48af5c17f72a711569
Autor:
Arman A. Sadybekov, Rebecca L. Brouillette, Egor Marin, Anastasiia V. Sadybekov, Aleksandra Luginina, Anastasiia Gusach, Alexey Mishin, Élie Besserer-Offroy, Jean-Michel Longpré, Valentin Borshchevskiy, Vadim Cherezov, Philippe Sarret, Vsevolod Katritch
Publikováno v:
Biomolecules, Vol 10, Iss 12, p 1634 (2020)
Cysteinyl leukotriene G protein-coupled receptors, CysLT1R and CysLT2R, regulate bronchoconstrictive and pro-inflammatory effects and play a key role in allergic disorders, cardiovascular diseases, and cancer. CysLT1R antagonists have been widely use
Externí odkaz:
https://doaj.org/article/f10a2b76089f4d51a6bf3e664058debc
Autor:
Egor Marin, Aleksandra Luginina, Anastasiia Gusach, Kirill Kovalev, Sergey Bukhdruker, Polina Khorn, Vitaly Polovinkin, Elizaveta Lyapina, Andrey Rogachev, Valentin Gordeliy, Alexey Mishin, Vadim Cherezov, Valentin Borshchevskiy
Publikováno v:
Scientific Data, Vol 7, Iss 1, Pp 1-1 (2020)
A Correction to this paper has been published: https://doi.org/10.1038/s41597-020-00759-w
Externí odkaz:
https://doaj.org/article/2cc6e5f2b9104fa693fb6ef368ca0642