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Figure S4 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer

Supplemental Figure 4. mRNA abundance in triptolide-treated PDAC 001 cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044ab6530b2ed4c2d5e7b320e1b46136
https://doi.org/10.1158/1078-0432.22467947.v1

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Data from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer

Purpose: Even when diagnosed prior to metastasis, pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with almost 90% lethality, emphasizing the need for new therapies optimally targeting the tumors of individual patients.Experimental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a1455e510d91e5c694d3c949243e03
https://doi.org/10.1158/1078-0432.c.6526790

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Table S1 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer

AUC results of the drug sensitivity screens in conditionally reprogrammed PDAC cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4039f231d29e1a7194a11032483cd365
https://doi.org/10.1158/1078-0432.22467935.v1

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Tables S1 and S3 from Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer

Table S1. Genetic characterization of patient-derived xenografts using the Illumina Trusight panel capturing frequent mutations in 94 genes and 284 SNPs associated with cancer Table S3. Triptolide-induced effects on the mRNA abundance was determined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543f493b8ebfa3e16a9400f3b5eb30c4
https://doi.org/10.1158/1078-0432.22467932.v1

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Targeted delivery of chemotherapy using HSP90 inhibitor drug conjugates is highly active against pancreatic cancer models

Autor: David A. Proia, Natalia Skobeleva, Vladimir Khazak, Igor Astsaturov, Natalya Beglyarova, Egor Bobrov, Kathy Q. Cai, Diana Restifo, Elizabeth Handorf, Erica A. Golemis, Kerry S. Campbell

Publikováno v: Oncotarget

The lack of effective treatment modalities is a major problem in pancreatic cancer (PCa), a devastating malignancy that is nearly universally driven by the “undruggable” KRAS and TP53 cancer genes. Poor tumor tissue penetration is the major sourc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba3f1d9f072e937b9fc9141a8779010
https://pubmed.ncbi.nlm.nih.gov/27779106

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Abstract B07: Screening of patient-derived carcinoma cells and animal models identifies transcription as target in pancreatic cancer

Autor: Natalia Beglyarova, Sandra A. Jablonski, Vladimir Khazak, Keren Paz, Yan Zhou, Igor Astsaturov, Natalia Skobeleva, Louis M. Weiner, Egor Bobrov

Publikováno v: Clinical Cancer Research. 22:B07-B07

Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy that affects 44,000 individuals yearly in the US. With almost 90% lethality even when diagnosed prior to metastasis, there is an urgent unmet medical need for new therapies or better

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18b700acd51641a423ea6c39eb6ff794
https://doi.org/10.1158/1557-3265.pdx16-b07

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Elektronická kniha

Human Dignity in International Law

Autor: Ginevra Le Moli

Over the past two centuries, the concept of human dignity has moved from the fringes to the centre of the international legal system. This book is the first detailed historical, theoretical and legal investigation of human dignity as a normative valu

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