Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Egor A. Syroegin"'
Autor:
A.S.M. Zisanur Rahman, Egor A. Syroegin, Julieta Novomisky Nechcoff, Archit Devarajan, Yury S. Polikanov, Silvia T. Cardona
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114967- (2024)
Summary: Bacterial mutant libraries with downregulated antibiotic targets are useful tools for elucidating the mechanisms of action of antibacterial compounds, a pivotal step in antibiotic discovery. However, achieving genomic coverage of antibacteri
Externí odkaz:
https://doaj.org/article/dec81f5c2a76421fa935bd0875c98e1e
Autor:
Chih-Wei Chen, Nadja Leimer, Egor A. Syroegin, Clémence Dunand, Zackery P. Bulman, Kim Lewis, Yury S. Polikanov, Maxim S. Svetlov
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The ever-growing rise of antibiotic resistance among bacterial pathogens is one of the top healthcare threats today. Although combination antibiotic therapies represent a potential approach to more efficiently combat infections caused by sus
Externí odkaz:
https://doaj.org/article/246bbb654cbb41e497335ae0c30d2797
Publikováno v:
Nat Chem
During protein synthesis, the growing polypeptide threads through the ribosomal exit tunnel and modulates ribosomal activity by itself or by sensing various small molecules, such as metabolites or antibiotics, appearing in the tunnel. While arrested
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c09511ebba29e5ddf4161269b20b9ff
https://doi.org/10.1038/s41557-022-01073-1
https://doi.org/10.1038/s41557-022-01073-1
Autor:
Maxim S. Svetlov, Gemma C. Atkinson, Alexander S. Mankin, Elena V. Aleksandrova, Yury S. Polikanov, Egor A Syroegin, Steven T. Gregory
Publikováno v:
Nature chemical biology
Many antibiotics inhibit bacterial growth by binding to the ribosome and interfering with protein biosynthesis. Macrolides represent one of the most successful classes of ribosome-targeting antibiotics. The main clinically relevant mechanism of resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8178edc8a442b3d4479a3bf5afc75ea2
https://doi.org/10.1038/s41589-020-00715-0
https://doi.org/10.1038/s41589-020-00715-0
Autor:
Adriana Di Stasi, Marco Scocchi, Erica Valencic, Riccardo Sola, Dominic W. P. Collis, Daniel N. Wilson, Jure Borišek, Bertrand Beckert, Yury S. Polikanov, Alessandra Magistrato, Mario Mardirossian, Kai Hilpert, Egor A Syroegin, Jan Buchmann, Federica Armas
Publikováno v:
Journal of Medicinal Chemistry. 63:9590-9602
Proline-rich antimicrobial peptides (PrAMPs) are promising lead compounds for developing new antimicrobials, however their narrow spectrum of action is limiting. PrAMPs kill bacteria binding to their ribosomes and inhibiting protein synthesis. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c67b735ade8c4c233ddeaf848ffe81
https://doi.org/10.1021/acs.jmedchem.0c00665
https://doi.org/10.1021/acs.jmedchem.0c00665
Autor:
Egor A. Syroegin, Laurin Flemmich, Dorota Klepacki, Nora Vazquez-Laslop, Ronald Micura, Yury S. Polikanov
Publikováno v:
Nat Struct Mol Biol
Ribosome-targeting antibiotics serve as powerful antimicrobials and as tools for studying the ribosome, the catalytic peptidyl transferase center (PTC) of which is targeted by many drugs. The classic PTC-acting antibiotic chloramphenicol (CHL) and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baec779b058957314915defbfc42a2e8
https://europepmc.org/articles/PMC9071271/
https://europepmc.org/articles/PMC9071271/
Autor:
Laurin Flemmich, Egor A Syroegin, Ronald Micura, Yury S. Polikanov, Nora Vázquez-Laslop, Dorota Klepacki
Ribosome-targeting antibiotics serve both as powerful antimicrobials and as tools for studying the ribosome. The ribosomal catalytic site, the peptidyl transferase center (PTC), is targeted by a large number of various drugs. The classical and best-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f614ad5a7e86cf43db5419c59b2bcab3
https://doi.org/10.1101/2021.06.17.448903
https://doi.org/10.1101/2021.06.17.448903
Autor:
Kelvin J. Y. Wu, Giambattista Testolin, Alexander S. Mankin, Daniel W. Terwilliger, Amarnath Pisipati, Katherine J. Silvestre, Andrew G. Myers, Matthew J. Mitcheltree, Kelly Chatman, Egor A Syroegin, Jeremy D. Mason, Richard Porter Ladley, Aditya R. Pote, Yury S. Polikanov, Dorota Klepacki
Publikováno v:
Nature. 599(7885)
The dearth of new medicines effective against antibiotic-resistant bacteria presents a growing global public health concern1. For more than five decades, the search for new antibiotics has relied heavily on the chemical modification of natural produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358e9add280ea59a94a0a3ef98030545
https://pubmed.ncbi.nlm.nih.gov/34754106
https://pubmed.ncbi.nlm.nih.gov/34754106
Autor:
Matthew Mitcheltree, Amarnath Pisipati, Egor A. Syroegin, Katherine J. Silvestre, Dorota Klepacki, Jeremy Mason, Daniel W. Terwilliger, Giambattista Testolin, Aditya R. Pote, Kelvin J. Y. Wu, Richard Porter Ladley, Kelly Chatman, Alexander S. Mankin, Yury S. Polikanov, Andrew G. Myers
The dearth of new medicines effective against antibiotic-resistant bacteria presents a growing global public health concern. For more than five decades, the search for new antibiotics has relied heavily upon the chemical modification of natural produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f22f369c6e889625ce58f5d324896d3
https://doi.org/10.26434/chemrxiv.14331407
https://doi.org/10.26434/chemrxiv.14331407
Autor:
Nelli F. Khabibullina, Andrey G. Tereshchenkov, Ekaterina S. Komarova, Egor A. Syroegin, Dmitrii I. Shiriaev, Alena Paleskava, Victor G. Kartsev, Alexey A. Bogdanov, Andrey L. Konevega, Olga A. Dontsova, Petr V. Sergiev, Ilya A. Osterman, Yury S. Polikanov
Publikováno v:
Antimicrobial agents and chemotherapy. 63(6)
Although macrolides are known as excellent antibacterials, their medical use has been significantly limited due to the spread of bacterial drug resistance. Therefore, it is necessary to develop new potent macrolides to combat the emergence of drug-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c73cf776b491e29f41384a294607a93e
https://pubmed.ncbi.nlm.nih.gov/31988110
https://pubmed.ncbi.nlm.nih.gov/31988110