Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Egon, Ogris"'
Autor:
Reyaz ur Rasool, Caitlin M. O’Connor, Chandan Kanta Das, Mohammed Alhusayan, Brijesh Kumar Verma, Sehbanul Islam, Ingrid E. Frohner, Qu Deng, Erick Mitchell-Velasquez, Jaya Sangodkar, Aqila Ahmed, Sarah Linauer, Ingrid Mudrak, Jessica Rainey, Kaitlin P. Zawacki, Tahra K. Suhan, Catherine G. Callahan, Ryan Rebernick, Ramakrishnan Natesan, Javed Siddiqui, Guido Sauter, Dafydd Thomas, Shaomeng Wang, Derek J. Taylor, Ronald Simon, Marcin Cieslik, Arul M. Chinnaiyan, Luca Busino, Egon Ogris, Goutham Narla, Irfan A. Asangani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Loss of the tumor suppressive activity of the protein phosphatase 2A (PP2A) is associated with cancer, but the underlying molecular mechanisms are unclear. PP2A holoenzyme comprises a heterodimeric core, a scaffolding A subunit and a catalyt
Externí odkaz:
https://doaj.org/article/7ea3b219c8a941b89ece9e99f3bc0149
Autor:
Spencer D. Balay, Tobias Hochstoeger, Alexandra Vilceanu, E. Pascal Malkemper, William Snider, Gerhard Dürnberger, Karl Mechtler, Stefan Schuechner, Egon Ogris, Gregory C. Nordmann, Lyubov Ushakova, Simon Nimpf, David A. Keays
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Cryptochromes (CRY) are highly conserved signalling molecules that regulate circadian rhythms and are candidate radical pair based magnetoreceptors. Birds have at least four cryptochromes (CRY1a, CRY1b, CRY2, and CRY4), but few studies have
Externí odkaz:
https://doaj.org/article/088540efee3c4edaa5c3ab06f0fe4c93
Autor:
Ingrid E. Frohner, Ingrid Mudrak, Stefan Schüchner, Dorothea Anrather, Markus Hartl, Jean-Marie Sontag, Estelle Sontag, Brian E. Wadzinski, Teresa Preglej, Wilfried Ellmeier, Egon Ogris
Publikováno v:
Cell Reports, Vol 30, Iss 9, Pp 3171-3182.e6 (2020)
Summary: Protein phosphatase 2A (PP2A) is an important regulator of signal transduction pathways and a tumor suppressor. Phosphorylation of the PP2A catalytic subunit (PP2AC) at tyrosine 307 has been claimed to inactivate PP2A and was examined in mor
Externí odkaz:
https://doaj.org/article/12025806a45840e6a5dff7f2dc343abb
Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies
Autor:
Eduard Stefan, Omar Torres-Quesada, Egon Ogris, Johanna E. Mayrhofer, Philipp Tschaikner, Andreas Feichtner, Florian Enzler, Andrea Raffeiner, Jakob Troppmair, Markus Hartl, Rainer Schneider, Roland G. Huber, Ruth Röck, Jakob Fleischmann
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The pharmaceutical targeting of mutated BRAF has shown promising clinical outcomes in patients with melanoma. However, more than 300 reported BRAF patient mutations and the occurrence of a kinase-drug resistance mechanism hamper patient-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd40c2c1fcc0d48064d424aa4bada7f
https://doi.org/10.1073/pnas.2012150117
https://doi.org/10.1073/pnas.2012150117
Autor:
Gabriela Gérecová, Egon Ogris, Natalie Romanov, Jessica Ferrari, Reinhard Beyer, Christoph Schüller, Jiri Veis, Marion Janschitz, David Maria Hollenstein, Wolfgang Reiter, Gustav Ammerer, Markus Hartl
Publikováno v:
EMBO Reports
Changing environmental cues lead to the adjustment of cellular physiology by phosphorylation signaling networks that typically center around kinases as active effectors and phosphatases as antagonistic elements. Here, we report a signaling mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515b7945d0a744275b093523fbde9e39
https://doi.org/10.15252/embr.202152476
https://doi.org/10.15252/embr.202152476
Autor:
Ryotaro Yabe, Akane Miura, Tatsuya Usui, Ingrid Mudrak, Egon Ogris, Takashi Ohama, Koichi Sato
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145226 (2015)
Protein phosphatase 2A (PP2A) is a conserved essential enzyme that is implicated as a tumor suppressor based on its central role in phosphorylation-dependent signaling pathways. Protein phosphatase methyl esterase (PME-1) catalyzes specifically the d
Externí odkaz:
https://doaj.org/article/b9e1f577414e4c8a9b168a027e3190a8
Autor:
Wei Huang, Shirish Shenolikar, Egon Ogris, Caitlin M. O’Connor, Daniel Leonard, Analisa DiFeo, Goutham Narla, Derek J. Taylor, David L. Brautigan
Publikováno v:
SSRN Electronic Journal.
While we appreciate the importance of independent validation of scientific discoveries and, thus, welcome all follow-up studies that evaluate the reported cytotoxic effects of DT-061 on cancer cells, we are somewhat flabbergasted by the claim by Nils
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::121e83bfa000658e1710310e183468d8
https://doi.org/10.2139/ssrn.3950751
https://doi.org/10.2139/ssrn.3950751
Autor:
Maria Angeles Juanes, Rita Khoueiry, Thomas Kupka, Anna Castro, Ingrid Mudrak, Egon Ogris, Thierry Lorca, Simonetta Piatti
Publikováno v:
PLoS Genetics, Vol 9, Iss 7, p e1003575 (2013)
Entry into mitosis is triggered by cyclinB/Cdk1, whose activity is abruptly raised by a positive feedback loop. The Greatwall kinase phosphorylates proteins of the endosulfine family and allows them to bind and inhibit the main Cdk1-counteracting PP2
Externí odkaz:
https://doaj.org/article/cf040cdf2f4c44668573818473e36869
Autor:
Gabriela Gérecová, Egon Ogris, David Maria Hollenstein, Gustav Ammerer, Markus Hartl, Natalie Romanov, Jiri Veis, Wolfgang Reiter
Publikováno v:
Microbiological Research
InSaccharomyces cerevisiaeimpairment of protein phosphatase PP2ARts1leads to temperature and hyperosmotic stress sensitivity, yet the underlying mechanism and the scope of action of the phosphatase in the stress response remain elusive. Using quantit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9647e9b4a5203de93adc5945d9408acb
https://doi.org/10.1101/2020.05.30.124925
https://doi.org/10.1101/2020.05.30.124925
Publikováno v:
Sci Signal
The methyl-esterification of the C-terminal leucine of the protein phosphatase 2A (PP2A) catalytic (C) subunit is essential for the assembly of specific trimeric PP2A holoenzymes, and this region of the C subunit also contains two threonine and tyros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d7a8298088dcc1706975f89a597b09c
https://doi.org/10.1126/scisignal.aax6490
https://doi.org/10.1126/scisignal.aax6490