Germline pathogenic variants in neuroblastoma patients are enriched in BARD1 and predict worse survival.

Autor: Kim J; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA., Vaksman Z; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Egolf LE; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kaufman R; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Evans JP; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Conkrite KL; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Danesh A; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, ON, Canada., Lopez G; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Randall MP; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Dent MH; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Farra LM; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Menghani NL; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Dymek M; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Desai H; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hausler R; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hicks B; Cancer Genome Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Auvil JG; Office of Cancer Genomics, National Cancer Institute, Bethesda, MD, USA., Gerhard DS; Office of Cancer Genomics, National Cancer Institute, Bethesda, MD, USA., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Maxwell KN; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Cole KA; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Pugh TJ; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Bosse KR; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Khan J; Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Wei JS; Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Maris JM; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Stewart DR; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA., Diskin SJ; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Publikováno v: Journal of the National Cancer Institute [J Natl Cancer Inst] 2024 Jan 10; Vol. 116 (1), pp. 149-159.

OpenPBTA: The Open Pediatric Brain Tumor Atlas.

Autor: Shapiro JA; Childhood Cancer Data Lab, Alex's Lemonade Stand Foundation, Bala Cynwyd, PA 19004, USA., Gaonkar KS; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Spielman SJ; Childhood Cancer Data Lab, Alex's Lemonade Stand Foundation, Bala Cynwyd, PA 19004, USA.; Rowan University, Glassboro, NJ 08028, USA., Savonen CL; Childhood Cancer Data Lab, Alex's Lemonade Stand Foundation, Bala Cynwyd, PA 19004, USA., Bethell CJ; Childhood Cancer Data Lab, Alex's Lemonade Stand Foundation, Bala Cynwyd, PA 19004, USA., Jin R; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Rathi KS; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Zhu Y; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Egolf LE; Cell and Molecular Biology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Farrow BK; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Miller DP; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Yang Y; Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA., Koganti T; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Noureen N; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, TX 78229, USA., Koptyra MP; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Duong N; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Santi M; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Kim J; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA., Robins S; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Storm PB; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Mack SC; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Lilly JV; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Xie HM; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Jain P; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Raman P; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Rood BR; Children's National Research Institute, Washington, DC 20012, USA.; George Washington University School of Medicine and Health Sciences, Washington, DC 20052, USA., Lulla RR; Division of Hematology/Oncology, Hasbro Children's Hospital, Providence, RI 02903, USA.; Department of Pediatrics, The Warren Alpert School of Brown University, Providence, RI 02912, USA., Nazarian J; Children's National Research Institute, Washington, DC 20012, USA.; George Washington University School of Medicine and Health Sciences, Washington, DC 20052, USA.; Department of Pediatrics, University of Zurich, Zurich, Switzerland., Kraya AA; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Vaksman Z; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Heath AP; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Kline C; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Scolaro L; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Viaene AN; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA., Huang X; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Way GP; Department of Biomedical Informatics, University of Colorado School of Medicine, Aurora, CO 80045, USA., Foltz SM; Childhood Cancer Data Lab, Alex's Lemonade Stand Foundation, Bala Cynwyd, PA 19004, USA.; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA., Zhang B; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Poetsch AR; Biotechnology Center, Technical University Dresden, Dresden, Germany.; National Center for Tumor Diseases, Dresden, Germany., Mueller S; Department of Neurology, Neurosurgery and Pediatrics, University of California, San Francisco, San Francisco, CA 94115, USA., Ennis BM; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Prados M; University of California, San Francisco, San Francisco, CA 94115, USA., Diskin SJ; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA., Zheng S; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, TX 78229, USA., Guo Y; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Kannan S; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Waanders AJ; Division of Hematology, Oncology, Neuro-Oncology, and Stem Cell Transplant, Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA.; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Margol AS; Division of Hematology and Oncology, Children's Hospital of Los Angeles, Los Angeles, CA 90027, USA.; Department of Pediatrics, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA., Kim MC; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Hanson D; Hackensack Meridian School of Medicine, Nutley, NJ 07110, USA.; Hackensack University Medical Center, Hackensack, NJ 07601, USA., Van Kuren N; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Wong J; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Kaufman RS; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Coleman N; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Blackden C; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Cole KA; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA.; Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Mason JL; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Madsen PJ; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Koschmann CJ; Department of Pediatrics, University of Michigan Health, Ann Arbor, MI 48105, USA.; Pediatric Hematology Oncology, Mott Children's Hospital, Ann Arbor, MI 48109, USA., Stewart DR; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA., Wafula E; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Brown MA; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Resnick AC; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Greene CS; Childhood Cancer Data Lab, Alex's Lemonade Stand Foundation, Bala Cynwyd, PA 19004, USA.; Department of Biomedical Informatics, University of Colorado School of Medicine, Aurora, CO 80045, USA.; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Rokita JL; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Taroni JN; Childhood Cancer Data Lab, Alex's Lemonade Stand Foundation, Bala Cynwyd, PA 19004, USA.

Publikováno v: Cell genomics [Cell Genom] 2023 May 31; Vol. 3 (7), pp. 100340. Date of Electronic Publication: 2023 May 31 (Print Publication: 2023).

Germline pathogenic variants in 786 neuroblastoma patients.

Autor: Kim J; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA., Vaksman Z; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Egolf LE; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kaufman R; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Evans JP; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Conkrite KL; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Danesh A; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, ON, M5S Canada., Lopez G; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Randall MP; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Dent MH; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Farra LM; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Menghani N; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Dymek M; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Desai H; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hausler R; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Auvil JG; Office of Cancer Genomics, National Cancer Institute, Bethesda, MD, USA., Gerhard DS; Office of Cancer Genomics, National Cancer Institute, Bethesda, MD, USA., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Maxwell KN; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Cole KA; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Pugh TJ; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, ON, M5S Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, ON, M5S Canada., Bosse KR; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Khan J; Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA., Wei JS; Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA., Maris JM; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Stewart DR; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA., Diskin SJ; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Jan 25. Date of Electronic Publication: 2023 Jan 25.

Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design.

Autor: Rokita JL; Division of Oncology, Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Rathi KS; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Cardenas MF; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Upton KA; Division of Oncology, Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA., Jayaseelan J; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Cross KL; Guardian Forensic Sciences, Abington, PA 19001, USA., Pfeil J; UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA., Egolf LE; Division of Oncology, Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA; Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA., Way GP; Genomics and Computational Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA., Farrel A; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Kendsersky NM; Division of Oncology, Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA., Patel K; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Gaonkar KS; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Modi A; Division of Oncology, Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA; Genomics and Computational Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA., Berko ER; Division of Oncology, Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA., Lopez G; Division of Oncology, Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Vaksman Z; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Mayoh C; Children's Cancer Institute, School of Women's and Children's Health, UNSW Sydney, Sydney, NSW, Australia., Nance J; Cancer Center, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX 79430, USA., McCoy K; Cancer Center, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX 79430, USA., Haber M; Children's Cancer Institute, School of Women's and Children's Health, UNSW Sydney, Sydney, NSW, Australia., Evans K; Children's Cancer Institute, School of Women's and Children's Health, UNSW Sydney, Sydney, NSW, Australia., McCalmont H; Children's Cancer Institute, School of Women's and Children's Health, UNSW Sydney, Sydney, NSW, Australia., Bendak K; Children's Cancer Institute, School of Women's and Children's Health, UNSW Sydney, Sydney, NSW, Australia., Böhm JW; Children's Cancer Institute, School of Women's and Children's Health, UNSW Sydney, Sydney, NSW, Australia., Marshall GM; Children's Cancer Institute, School of Women's and Children's Health, UNSW Sydney, Sydney, NSW, Australia; Sydney Children's Hospital, Sydney, NSW, Australia., Tyrrell V; Children's Cancer Institute, Kensington, NSW, Australia., Kalletla K; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Braun FK; Texas Children's Cancer and Hematology Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA., Qi L; Preclinical Neurooncology Research Program, Texas Children's Cancer Research Center, Texas Children's Hospital, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA., Du Y; Preclinical Neurooncology Research Program, Texas Children's Cancer Research Center, Texas Children's Hospital, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA., Zhang H; Preclinical Neurooncology Research Program, Texas Children's Cancer Research Center, Texas Children's Hospital, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA., Lindsay HB; Preclinical Neurooncology Research Program, Texas Children's Cancer Research Center, Texas Children's Hospital, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA., Zhao S; Preclinical Neurooncology Research Program, Texas Children's Cancer Research Center, Texas Children's Hospital, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA., Shu J; Preclinical Neurooncology Research Program, Texas Children's Cancer Research Center, Texas Children's Hospital, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA., Baxter P; Preclinical Neurooncology Research Program, Texas Children's Cancer Research Center, Texas Children's Hospital, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA., Morton C; Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Kurmashev D; Greehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA., Zheng S; Greehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA., Chen Y; Greehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA., Bowen J; The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA., Bryan AC; The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA., Leraas KM; The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA., Coppens SE; The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA., Doddapaneni H; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Momin Z; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Zhang W; Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Sacks GI; Division of Oncology, Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA., Hart LS; Division of Oncology, Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA., Krytska K; Division of Oncology, Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA., Mosse YP; Division of Oncology, Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA., Gatto GJ; Department of Global Health Technologies, RTI International, Research Triangle Park, NC 27709, USA., Sanchez Y; Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA; Norris Cotton Cancer Center, Lebanon, NH 03766, USA., Greene CS; Childhood Cancer Data Lab, Alex's Lemonade Stand Foundation, Philadelphia, PA 19102, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA., Diskin SJ; Division of Oncology, Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Vaske OM; Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA., Haussler D; UC Santa Cruz Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA; Howard Hughes Medical Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA., Gastier-Foster JM; The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA; The Ohio State University College of Medicine, Departments of Pathology and Pediatrics, Columbus, OH 43210, USA., Kolb EA; Department of Pediatrics, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, USA; Nemours Center for Cancer and Blood Disorders, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA., Gorlick R; Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Li XN; Preclinical Neurooncology Research Program, Texas Children's Cancer Research Center, Texas Children's Hospital, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Division of Hematology, Oncology, Neuro-oncology and Stem Cell Transplant, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Reynolds CP; Cancer Center, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX 79430, USA., Kurmasheva RT; Greehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA., Houghton PJ; Greehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA., Smith MA; National Cancer Institute, NIH, Bethesda, MD 20814, USA., Lock RB; Children's Cancer Institute, Kensington, NSW, Australia., Raman P; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Wheeler DA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Maris JM; Division of Oncology, Children's Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-4318, USA. Electronic address: maris@email.chop.edu.

Publikováno v: Cell reports [Cell Rep] 2019 Nov 05; Vol. 29 (6), pp. 1675-1689.e9.