GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity

Autor: Serena Melgrati, Oliver J. Gerken, Marc Artinger, Egle Radice, Martyna Szpakowska, Andy Chevigné, Giulia D’Uonnolo, Paola Antonello, Sylvia Thelen, Pawel Pelczar, Daniel F. Legler, Marcus Thelen

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Immune responses highly depend on the effective trafficking of immune cells into and within secondary lymphoid organs (SLOs). Atypical chemokine receptors (ACKRs) scavenge chemokines to eliminate them from the extracellular space, thereby generating

Externí odkaz: https://doaj.org/article/9970cfc4f4c44b67969d20b2bd45a28c

ACKR3 promotes CXCL12/CXCR4-mediated cell-to-cell-induced lymphoma migration through LTB4 production

Autor: Paola Antonello, Diego U. Pizzagalli, Mathilde Foglierini, Serena Melgrati, Egle Radice, Sylvia Thelen, Marcus Thelen

Publikováno v: Frontiers in Immunology, Vol 13 (2023)

Chemotaxis is an essential physiological process, often harnessed by tumors for metastasis. CXCR4, its ligand CXCL12 and the atypical receptor ACKR3 are overexpressed in many human cancers. Interfering with this axis by ACKR3 deletion impairs lymphom

Externí odkaz: https://doaj.org/article/82691c7cee7b459e96d494009acf3c8b

CXCL12α/SDF‐1 from perisynaptic Schwann cells promotes regeneration of injured motor axon terminals

Autor: Samuele Negro, Francesca Lessi, Elisa Duregotti, Paolo Aretini, Marco La Ferla, Sara Franceschi, Michele Menicagli, Elisanna Bergamin, Egle Radice, Marcus Thelen, Aram Megighian, Marco Pirazzini, Chiara M Mazzanti, Michela Rigoni, Cesare Montecucco

Publikováno v: EMBO Molecular Medicine, Vol 9, Iss 8, Pp 1000-1010 (2017)

Abstract The neuromuscular junction has retained through evolution the capacity to regenerate after damage, but little is known on the inter‐cellular signals involved in its functional recovery from trauma, autoimmune attacks, or neurotoxins. We re

Externí odkaz: https://doaj.org/article/63ca5aa313ec418b84d41f90979ff79c

ACKR3 expression on diffuse large B cell lymphoma is required for tumor spreading and tissue infiltration

Autor: Sabrina Casella, Stefan Dirnhofer, Egle Radice, Sylvia Thelen, Francesco Bertoni, Marcus Thelen, Viola Puddinu

Publikováno v: Oncotarget
Puddinu, Viola; Casella, Sabrina; Radice, Egle; Thelen, Sylvia; Dirnhofer, Stefan; Bertoni, Francesco; Thelen, Marcus (2017). ACKR3 expression on diffuse large B cell lymphoma is required for tumor spreading and tissue infiltration. OncoTarget, 8(49), pp. 85068-85084. Impact Journals LLC 10.18632/oncotarget.18844

Diffuse large B cell lymphoma (DLBCL) is the most frequent lymphoma accounting for more than the 30% of the cases. Involvement of extranodal sites, such as bone marrow and central nervous system, is associated with poor prognosis. A contribution of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990e90b81f2839cff0ac2e53d223a83b
http://europepmc.org/articles/PMC5689594

Characterization of a chimeric chemokine as a specific ligand for ACKR3

Autor: Marcus Thelen, Serena Melgrati, Antal Rot, Elisabetta Cameroni, Rafet Ameti, Egle Radice, Sylvia Thelen, Elin Hub

Publikováno v: Ameti, Rafet; Melgrati, Serena; Radice, Egle; Cameroni, Elisabetta; Hub, Elin; Thelen, Sylvia; Rot, Antal; Thelen, Marcus (2018). Characterization of a chimeric chemokine as a specific ligand for ACKR3. Journal of leukocyte biology, 104(2), pp. 391-400. Society for Leukocyte Biology 10.1002/JLB.2MA1217-509R

Chemokines, small chemotactic cytokines, orchestrate cell migration by binding to their cognate chemokine receptors. While chemokine-mediated stimulation of typical G-protein-coupled chemokine receptors leads to cell migration, binding of chemokines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c3017f687bc160ff13c0d27fde43ae
https://pubmed.ncbi.nlm.nih.gov/29601107