High density of TCF1+ stem-like tumor-infiltrating lymphocytes is associated with favorable disease-specific survival in NSCLC

Autor: Dagny Førde, Thomas Kilvær, Mona Irene Pedersen, Egil S Blix, Ilona Urbarova, Erna-Elise Paulsen, Mehrdad Rakaee, Lill-Tove Rasmussen Busund, Tom Donnem, Sigve Andersen

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionTumor-infiltrating lymphocytes are both prognostic and predictive biomarkers for immunotherapy response. However, less is known about the survival benefits oftheir subpopulations.MethodsUsing machine learning models, we assessed the clini

Externí odkaz: https://doaj.org/article/757f0a38143c48e79d7e199fbd984086

Dosimetric assessment of an Atlas based automated segmentation for loco-regional radiation therapy of early breast cancer in the Skagen Trial 1: A multi-institutional study

Autor: Ahmed R. Eldesoky, Giulio Francolini, Mette S. Thomsen, Esben S. Yates, Tine B. Nyeng, Carine Kirkove, Claus Kamby, Egil S. Blix, Mette H. Nielsen, Zahra Taheri-Kadkhoda, Martin Berg, Birgitte V. Offersen

Publikováno v: Clinical and Translational Radiation Oncology, Vol 2, Iss C, Pp 36-40 (2017)

The effect of Atlas-based automated segmentation (ABAS) on dose volume histogram (DVH) parameters compared to manual segmentation (MS) in loco-regional radiotherapy (RT) of early breast cancer was investigated in patients included in the Skagen Trial

Externí odkaz: https://doaj.org/article/fbec48d72b1e4bf78fa6be387266cc22

A national precision cancer medicine implementation initiative for Norway

Autor: Kjetil, Taskén, Hege E G, Russnes, Eline, Aas, Line, Bjørge, Egil S, Blix, Espen, Enerly, Gro L, Fagereng, Åsmund, Flobak, Bjørnar, Gilje, Bjørn T, Gjertsen, Tormod K, Guren, Jutta, Heix, Eivind, Hovig, Randi, Hovland, Per E, Lønning, Leonardo A, Meza-Zepeda, Per M, Mæhle, Hilde L, Nilsen, Steinar Ø, Thoresen, Ketil, Widerberg, Sigbjørn, Smeland, Sissel F, Wahl

Publikováno v: Nature medicine. 28(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::35bd36bb6ee99d6e72d34ce81372c985
https://pubmed.ncbi.nlm.nih.gov/35513529

Low Z-4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen

Autor: Steinar Hustad, Marit Synnestvedt, Jan Terje Kvaløy, Daniel L. Hertz, Anna Barbro Sætersdal, Gunnar Mellgren, Bjørnar Gilje, Elin Borgen, Ingvil Mjaaland, Håvard Søiland, Egil S. Blix, Emiel A. M. Janssen, Tone Hoel Lende, Kjetil Weyde, Gro Wiedswang, Bjørn Naume, Ersilia Bifulco, Thomas Helland

Publikováno v: Molecular Oncology
Molecular Oncology, Vol 15, Iss 4, Pp 957-967 (2021)

Concentrations of active tamoxifen metabolites may be predictive of tamoxifen efficacy, and several therapeutic thresholds have been reported. This study of 406 ER+ breast cancer patients replicated an association between a previously reported active

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::243949774badb71683ce2b2d125a5556
https://pubmed.ncbi.nlm.nih.gov/33252186

Dosimetric assessment of an Atlas based automated segmentation for loco-regional radiation therapy of early breast cancer in the Skagen Trial 1: A multi-institutional study

Autor: M.H. Nielsen, Carine Kirkove, Birgitte Vrou Offersen, Giulio Francolini, Zahra Taheri-Kadkhoda, T.B. Nyeng, M.S. Thomsen, Ahmed R Eldesoky, Egil S. Blix, Martin Berg, E.S. Yates, Claus Kamby

Publikováno v: Clinical and Translational Radiation Oncology
Eldesoky, A R, Francolini, G, Thomsen, M S, Yates, E S, Nyeng, T B, Kirkove, C, Kamby, C, Blix, E S, Nielsen, M H, Taheri-Kadkhoda, Z, Berg, M & Offersen, B V 2017, ' Dosimetric assessment of an Atlas based automated segmentation for loco-regional radiation therapy of early breast cancer in the Skagen Trial 1 : A multi-institutional study ', Clinical and Translational Radiation Oncology, vol. 2, pp. 36-40 . https://doi.org/10.1016/j.ctro.2017.01.004
Clinical and Translational Radiation Oncology, Vol 2, Iss C, Pp 36-40 (2017)
Ibrahim, A R M E, Francolini, G, Thomsen, M S, Yates, E S, Nyeng, T B, Kirkove, C, Kamby, C, Blix, E S, Nielsen, M H, Taheri-Kadkhoda, Z, Berg, M & Offersen, B V 2017, ' Dosimetric assessment of an Atlas based automated segmentation for loco-regional radiation therapy of early breast cancer in the Skagen Trial 1: A multi-institutional study ', Clinical and Translational Radiation Oncology, vol. 2, pp. 36-40 . https://doi.org/10.1016/j.ctro.2017.01.004

Highlights • 40 dose plans from the Skagen Trial 1 collected from Denmark, Belgium and Norway. • Atlas-based automated segmentation of each CT scan was obtained using MIM Maestro™. • DSC and difference in volume with manual segmentation were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea72e81306d872e7688a0430d12fad55
https://doi.org/10.1016/j.ctro.2017.01.004