Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Egidio Brocca-Cofano"'
Autor:
Quentin Le Hingrat, Paola Sette, Cuiling Xu, Andrew R. Rahmberg, Lilas Tarnus, Haritha Annapureddy, Adam Kleinman, Egidio Brocca-Cofano, Ranjit Sivanandham, Sindhuja Sivanandham, Tianyu He, Daniel J. Capreri, Dongzhu Ma, Jacob D. Estes, Jason M. Brenchley, Cristian Apetrei, Ivona Pandrea
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
HIV infection results in the depletion of CD4+ T cells overtime and the loss of coordinated cellular immunity, but how this corresponds to the SIV infected African Green Monkey (AGM) model of non-progressive disease is not known. Here the authors ass
Externí odkaz:
https://doaj.org/article/3fb3a179a4c24353b99b12d1f312421c
Autor:
Cristian Apetrei, Thaidra Gaufin, Egidio Brocca-Cofano, Ranjit Sivanandham, Paola Sette, Tianyu He, Sindhuja Sivanandham, Natalie Martinez Sosa, Kathryn J. Martin, Kevin D. Raehtz, Adam J. Kleinman, Audrey Valentine, Noah Krampe, Rajeev Gautam, Andrew A. Lackner, Alan L. Landay, Ruy M. Ribeiro, Ivona Pandrea
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
Resolution of T cell activation and inflammation is a key determinant of the lack of SIV disease progression in African green monkeys (AGMs). Although frequently considered together, T cell activation occurs in response to viral stimulation of acquir
Externí odkaz:
https://doaj.org/article/f3187b8d640d4184b98561564f00b330
Autor:
Adam J. Kleinman, Cuiling Xu, Mackenzie L. Cottrell, Ranjit Sivanandham, Egidio Brocca-Cofano, Tammy Dunsmore, Angela Kashuba, Ivona Pandrea, Cristian Apetrei
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
HIV/SIV persistence in latent reservoirs requires lifelong antiretroviral treatment and calls for effective cure strategies. Romidepsin (RMD), a histone deacetylase inhibitor, was reported to reactivate HIV/SIV from reservoirs in virus-suppressed ind
Externí odkaz:
https://doaj.org/article/ef8bf49cdf2248aba4360f54aa88919b
Autor:
Kevin D Raehtz, Fredrik Barrenäs, Cuiling Xu, Kathleen Busman-Sahay, Audrey Valentine, Lynn Law, Dongzhu Ma, Benjamin B Policicchio, Viskam Wijewardana, Egidio Brocca-Cofano, Anita Trichel, Michael Gale, Brandon F Keele, Jacob D Estes, Cristian Apetrei, Ivona Pandrea
Publikováno v:
PLoS Pathogens, Vol 16, Iss 3, p e1008333 (2020)
Unlike HIV infection, SIV infection is generally nonpathogenic in natural hosts, such as African green monkeys (AGMs), despite life-long high viral replication. Lack of disease progression was reportedly based on the ability of SIV-infected AGMs to p
Externí odkaz:
https://doaj.org/article/5c90518ccf3c43f8b835fdcb20bf9cea
Autor:
Silvia Zucchini, Anna Pittaluga, Egidio Brocca-Cofano, Maria Summa, Marina Fabris, Rita De Michele, Angela Bonaccorsi, Graziella Busatto, Giuseppe Barbanti-Brodano, Giuseppe Altavilla, Gianluca Verlengia, Pierangelo Cifelli, Alfredo Corallini, Antonella Caputo, Michele Simonato
Publikováno v:
Neurobiology of Disease, Vol 55, Iss , Pp 110-119 (2013)
HIV-1 associated neurocognitive disorders (HAND) are a major complication of HIV-1 infection. The mechanism(s) underlying HAND are not completely understood but, based on in vitro studies, the HIV-1 Tat protein may play an important role. In this stu
Externí odkaz:
https://doaj.org/article/5dd0a918d97449f79aafa9045a083613
Autor:
Benjamin B Policicchio, Cuiling Xu, Egidio Brocca-Cofano, Kevin D Raehtz, Tianyu He, Dongzhu Ma, Hui Li, Ranjit Sivanandham, George S Haret-Richter, Tammy Dunsmore, Anita Trichel, John W Mellors, Beatrice H Hahn, George M Shaw, Ruy M Ribeiro, Ivona Pandrea, Cristian Apetrei
Publikováno v:
PLoS Pathogens, Vol 12, Iss 9, p e1005879 (2016)
Viruses that persist despite seemingly effective antiretroviral treatment (ART) and can reinitiate infection if treatment is stopped preclude definitive treatment of HIV-1 infected individuals, requiring lifelong ART. Among strategies proposed for ta
Externí odkaz:
https://doaj.org/article/3daf4ca776254a4a8b06f61b75e5a81c
Autor:
Cristian Apetrei, Adam J. Kleinman, Brandon F. Keele, Ivona Pandrea, Egidio Brocca-Cofano, Colin McAndrews, Ranjit Sivanandham, Paola Sette
Publikováno v:
AIDS Res Hum Retroviruses
Up to 93% of the human immunodeficiency virus (HIV) latent reservoir comprised defective proviruses, suggesting that a functional cure is possible through the elimination of a small population of cells containing intact virus, instead of the entire r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac94c751d3b70e1cf76541f8bfb267e
https://doi.org/10.1089/aid.2021.0036
https://doi.org/10.1089/aid.2021.0036
Autor:
Adam J. Kleinman, Sindhuja Sivanandham, Paola Sette, Ranjit Sivanandham, Benjamin B. Policicchio, Cuiling Xu, Ellen Penn, Egidio Brocca-Cofano, Quentin Le Hingrat, Dongzhu Ma, Ivona Pandrea, Cristian Apetrei
Publikováno v:
J Virol
HIV persistence requires lifelong antiretroviral therapy (ART), calling for a cure. The histone deacetylase inhibitor, romidepsin, is used in the “shock and kill” approach with the goal of reactivating virus and subsequently clearing infected cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c058a6efe77b9b4869d70bce3469169e
https://pubmed.ncbi.nlm.nih.gov/35638831
https://pubmed.ncbi.nlm.nih.gov/35638831
Autor:
Sawa Ito, Christine Voigt, Tim Mayall, Mark J Shlomchik, Jennifer D Roy, Egidio Brocca Cofano, Stephanie Stras, David Apelian, Robert Keefe, Warren D Shlomchik
Publikováno v:
Blood. 140:7482-7483
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30a1152a8d9760f86998c628c31d5a7
https://doi.org/10.1182/blood-2022-168949
https://doi.org/10.1182/blood-2022-168949
Autor:
Sawa Ito, Constantinos G. Panousis, Alexander M. Rowe, Kedwin Ventura, Jennifer D. Roy, Stephanie Stras, Egidio Brocca-Cofano, Josh Kim, Mark J. Shlomchik, Warren D. Shlomchik
Publikováno v:
Cancer Research. 82:5189-5189
Hematopoietically-restricted minor histocompatibility antigens (miHAs) specific T cells can mediate graft-versus-leukemia and promote engraftment with a low risk of graft-vs-host disease in allogeneic stem cell transplantation (alloSCT). Thus the miH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba1b667771b75ccee64f9b3762ea0d39
https://doi.org/10.1158/1538-7445.am2022-5189
https://doi.org/10.1158/1538-7445.am2022-5189