In Acute Experimental Autoimmune Encephalomyelitis, Infiltrating Macrophages Are Immune Activated, Whereas Microglia Remain Immune Suppressed

Autor: Vainchtein, Id, Vinet, Jonathan, Brouwer, N, Brendecke, S, Biagini, Giuseppe, Biber, K, Boddeke, Hw, Eggen, Bj

Publikováno v: Glia, 62(10), 1724-1735. Wiley

Multiple sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous system (CNS) characterized by loss of myelin accompanied by infiltration of T-lymphocytes and monocytes. Although it has been shown that these infiltrates are impo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c4e2b27f8110543de0dccb5c3f0927d4
https://research.rug.nl/en/publications/2880f18c-6537-4ec4-b754-fbe905aed391

A novel microglial subset plays a key role in myelinogenesis in developing brain.

Autor: Wlodarczyk A; Department of Neurobiology Research, Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark., Holtman IR; Department of Neuroscience, Medical Physiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Krueger M; Institute for Anatomy, University of Leipzig, Leipzig, Germany., Yogev N; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Bruttger J; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Khorooshi R; Department of Neurobiology Research, Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark., Benmamar-Badel A; Department of Neurobiology Research, Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark.; Department of Biology, Ecole Normale Supérieure de Lyon, University of Lyon, Lyon, France., de Boer-Bergsma JJ; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Martin NA; Department of Neurology, Institute of Clinical Research, Odense University Hospital, Odense, Denmark., Karram K; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Kramer I; Department of Neurobiology Research, Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark., Boddeke EW; Department of Neuroscience, Medical Physiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Waisman A; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Eggen BJ; Department of Neuroscience, Medical Physiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Owens T; Department of Neurobiology Research, Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark towens@health.sdu.dk.

Publikováno v: The EMBO journal [EMBO J] 2017 Nov 15; Vol. 36 (22), pp. 3292-3308. Date of Electronic Publication: 2017 Sep 28.

Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes.

Autor: Gui H; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China.; Centre for Genomic Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China., Schriemer D; Department of Neuroscience, section Medical Physiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Cheng WW; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China.; Department of Clinical Genetics, Erasmus University Medical Center, PO Box 2040, 3000CA, Rotterdam, The Netherlands., Chauhan RK; Department of Clinical Genetics, Erasmus University Medical Center, PO Box 2040, 3000CA, Rotterdam, The Netherlands., Antiňolo G; Department of Genetics, Reproduction and Fetal Medicine, Institute of Biomedicine of Seville (IBIS), University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain.; Centre for Biomedical Network Research on Rare Diseases (CIBERER), Seville, Spain., Berrios C; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, USA., Bleda M; Centre for Biomedical Network Research on Rare Diseases (CIBERER), Seville, Spain.; Department of Medicine, School of Clinical Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Brooks AS; Department of Clinical Genetics, Erasmus University Medical Center, PO Box 2040, 3000CA, Rotterdam, The Netherlands., Brouwer RW; Erasmus Center for Biomics, Erasmus Medical Center, Rotterdam, The Netherlands., Burns AJ; Department of Clinical Genetics, Erasmus University Medical Center, PO Box 2040, 3000CA, Rotterdam, The Netherlands.; Stem Cells and Regenerative Medicine, Birth Defects Research Centre, UCL Institute of Child Health, London, UK., Cherny SS; Centre for Genomic Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China., Dopazo J; Department of Genetics, Reproduction and Fetal Medicine, Institute of Biomedicine of Seville (IBIS), University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain.; Centre for Biomedical Network Research on Rare Diseases (CIBERER), Seville, Spain., Eggen BJ; Department of Neuroscience, section Medical Physiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Griseri P; UOC Genetica Medica, Istituto Gaslini, Genoa, Italy., Jalloh B; Department of Biology, Emory University, Atlanta, USA., Le TL; Laboratory of embryology and genetics of human malformations, INSERM UMR 1163, Institut Imagine, Paris, France.; Department of Genetics, Paris Descartes-Sorbonne Paris Cité University, Hôpital Necker-Enfants Malades (APHP), Paris, France., Lui VC; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China., Luzón-Toro B; Department of Genetics, Reproduction and Fetal Medicine, Institute of Biomedicine of Seville (IBIS), University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain.; Centre for Biomedical Network Research on Rare Diseases (CIBERER), Seville, Spain., Matera I; UOC Genetica Medica, Istituto Gaslini, Genoa, Italy., Ngan ES; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China., Pelet A; Laboratory of embryology and genetics of human malformations, INSERM UMR 1163, Institut Imagine, Paris, France.; Department of Genetics, Paris Descartes-Sorbonne Paris Cité University, Hôpital Necker-Enfants Malades (APHP), Paris, France., Ruiz-Ferrer M; Department of Genetics, Reproduction and Fetal Medicine, Institute of Biomedicine of Seville (IBIS), University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain.; Centre for Biomedical Network Research on Rare Diseases (CIBERER), Seville, Spain., Sham PC; Centre for Genomic Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China., Shepherd IT; Department of Biology, Emory University, Atlanta, USA., So MT; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China., Sribudiani Y; Department of Clinical Genetics, Erasmus University Medical Center, PO Box 2040, 3000CA, Rotterdam, The Netherlands.; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia., Tang CS; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China., van den Hout MC; Erasmus Center for Biomics, Erasmus Medical Center, Rotterdam, The Netherlands., van der Linde HC; Department of Clinical Genetics, Erasmus University Medical Center, PO Box 2040, 3000CA, Rotterdam, The Netherlands., van Ham TJ; Department of Clinical Genetics, Erasmus University Medical Center, PO Box 2040, 3000CA, Rotterdam, The Netherlands., van IJcken WF; Erasmus Center for Biomics, Erasmus Medical Center, Rotterdam, The Netherlands., Verheij JB; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Amiel J; Laboratory of embryology and genetics of human malformations, INSERM UMR 1163, Institut Imagine, Paris, France.; Department of Genetics, Paris Descartes-Sorbonne Paris Cité University, Hôpital Necker-Enfants Malades (APHP), Paris, France., Borrego S; Department of Genetics, Reproduction and Fetal Medicine, Institute of Biomedicine of Seville (IBIS), University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain.; Centre for Biomedical Network Research on Rare Diseases (CIBERER), Seville, Spain., Ceccherini I; UOC Genetica Medica, Istituto Gaslini, Genoa, Italy., Chakravarti A; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, USA., Lyonnet S; Laboratory of embryology and genetics of human malformations, INSERM UMR 1163, Institut Imagine, Paris, France.; Department of Genetics, Paris Descartes-Sorbonne Paris Cité University, Hôpital Necker-Enfants Malades (APHP), Paris, France., Tam PK; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China., Garcia-Barceló MM; Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China. mmgarcia@hku.hk., Hofstra RM; Department of Clinical Genetics, Erasmus University Medical Center, PO Box 2040, 3000CA, Rotterdam, The Netherlands. r.hofstra@erasmusmc.nl.; Stem Cells and Regenerative Medicine, Birth Defects Research Centre, UCL Institute of Child Health, London, UK. r.hofstra@erasmusmc.nl.

Publikováno v: Genome biology [Genome Biol] 2017 Mar 08; Vol. 18 (1), pp. 48. Date of Electronic Publication: 2017 Mar 08.

Analysis of the cross-talk of Epstein-Barr virus-infected B cells with T cells in the marmoset.

Autor: Dunham J; Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands; Department of Neuroscience, University Groningen, University Medical Center, Groningen, The Netherlands., van Driel N; Department of Immunobiology, Biomedical Primate Research Centre , Rijswijk, The Netherlands., Eggen BJ; Department of Neuroscience, University Groningen, University Medical Center , Groningen, The Netherlands., Paul C; Department of Neuroscience, University Groningen, University Medical Center , Groningen, The Netherlands., 't Hart BA; Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands; Department of Neuroscience, University Groningen, University Medical Center, Groningen, The Netherlands., Laman JD; Department of Neuroscience, University Groningen, University Medical Center , Groningen, The Netherlands., Kap YS; Department of Immunobiology, Biomedical Primate Research Centre , Rijswijk, The Netherlands.

Publikováno v: Clinical & translational immunology [Clin Transl Immunology] 2017 Feb 10; Vol. 6 (2), pp. e127. Date of Electronic Publication: 2017 Feb 10 (Print Publication: 2017).

Identification of a conserved and acute neurodegeneration-specific microglial transcriptome in the zebrafish.

Autor: Oosterhof N; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, Wytemaweg 80, CN, 3015, The Netherlands., Holtman IR; Department of Neuroscience, Section Medical Physiology, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, 971 3, AV, Groningen, The Netherlands., Kuil LE; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, Wytemaweg 80, CN, 3015, The Netherlands., van der Linde HC; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, Wytemaweg 80, CN, 3015, The Netherlands., Boddeke EW; Department of Neuroscience, Section Medical Physiology, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, 971 3, AV, Groningen, The Netherlands., Eggen BJ; Department of Neuroscience, Section Medical Physiology, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, 971 3, AV, Groningen, The Netherlands., van Ham TJ; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, Wytemaweg 80, CN, 3015, The Netherlands.

Publikováno v: Glia [Glia] 2017 Jan; Vol. 65 (1), pp. 138-149. Date of Electronic Publication: 2016 Oct 19.