Zobrazeno 1 - 10 of 1 926 pro vyhledávání: '"Egerton, P."'
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Akademický článek
Longitudinal changes in DNA methylation associated with clozapine use in treatment-resistant schizophrenia from two international cohorts
Autor: Amy L. Gillespie, Emma M. Walker, Eilis Hannon, Grant A. McQueen, Kyra-Verena Sendt, Alessia Avila, John Lally, Cynthia Okhuijsen-Pfeifer, Marte van der Horst, Alkomiet Hasan, Emma L. Dempster, Joe Burrage, Jan Bogers, Dan Cohen, Marco P. Boks, David A. Collier, Alice Egerton, Jurjen J. Luykx, Jonathan Mill, James H. MacCabe
Publikováno v: Translational Psychiatry, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The second-generation antipsychotic clozapine is used as a medication for treatment-resistant schizophrenia. It has previously been associated with epigenetic changes in pre-clinical rodent models and cross-sectional studies of treatment-res
Externí odkaz: https://doaj.org/article/10cc9b0526224bc0a4cf3fb043bfa0a3
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2
Akademický článek
CLEAR – clozapine in early psychosis: study protocol for a multi-centre, randomised controlled trial of clozapine vs other antipsychotics for young people with treatment resistant schizophrenia in real world settings
Autor: C. Casetta, P. Santosh, R. Bayley, J. Bisson, S. Byford, C. Dixon, R. J. Drake, R. Elvins, R. Emsley, N. Fung, D. Hayes, O. Howes, A. James, K. James, R. Jones, H. Killaspy, B. Lennox, L. Marchant, P. McGuire, E. Oloyede, M. Rogdaki, R. Upthegrove, J. Walters, A. Egerton, J. H. MacCabe
Publikováno v: BMC Psychiatry, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background Clozapine is an antipsychotic drug with unique efficacy, and it is the only recommended treatment for treatment-resistant schizophrenia (TRS: failure to respond to at least two different antipsychotics). However, clozapine is also
Externí odkaz: https://doaj.org/article/a79cc4c7c9594a17a67cf81ccd5b9183
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3
Akademický článek
Chatbots and robots: a framework for the self-management of occupational stress
Autor: Akihiro Yorita, Simon Egerton, Carina Chan, Naoyuki Kubota
Publikováno v: ROBOMECH Journal, Vol 10, Iss 1, Pp 1-15 (2023)
Abstract We have developed a stress management framework aimed at helping healthcare professionals manage occupational stress. A chatbot is used to gather pertinent information from a user through regular conversation which is processed via a fuzzy i
Externí odkaz: https://doaj.org/article/ea62a7bbf4c244a2a8d77b4b0e1c9423
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5
Akademický článek
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6
Akademický článek
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7
Akademický článek
The relationship between striatal dopamine and anterior cingulate glutamate in first episode psychosis changes with antipsychotic treatment
Autor: Sameer Jauhar, Robert A. McCutcheon, Mattia Veronese, Faith Borgan, Matthew Nour, Maria Rogdaki, Fiona Pepper, James M. Stone, Alice Egerton, George Vamvakas, Federico Turkheimer, Philip K. McGuire, Oliver D. Howes
Publikováno v: Translational Psychiatry, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract The neuromodulator dopamine and excitatory neurotransmitter glutamate have both been implicated in the pathogenesis of psychosis, and dopamine antagonists remain the predominant treatment for psychotic disorders. To date no study has measure
Externí odkaz: https://doaj.org/article/8dd3d6e9caa94fe18290de30b46752d7
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8
Akademický článek
Inconsistently reporting post-licensure EPA specifications in different clinical professions hampers fidelity and practice translation: a scoping review
Autor: Sonya J. Moore, Thorlene Egerton, Mark Merolli, Jessica Lees, Nino La Scala, Selina M. Parry
Publikováno v: BMC Medical Education, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background Entrustable Professional Activities (EPAs) are defined units of professional practice entrusted to professionals once they have attained the specific competencies required to complete the end-to-end task. They provide a contempora
Externí odkaz: https://doaj.org/article/1ebad116619f44eeaa1f5c094671446c
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9
Akademický článek
Effects of a Massive Open Online Course on osteoarthritis knowledge and pain self-efficacy in people with hip and/or knee osteoarthritis: protocol for the MOOC-OA randomised controlled trial
Autor: Rachel K. Nelligan, Rana S. Hinman, Thorlene Egerton, Maya Gregory, Neil Bidgood, Ms Fiona McManus, Anurika P. De Silva, Karen E. Lamb, Kim L. Bennell
Publikováno v: BMC Musculoskeletal Disorders, Vol 24, Iss 1, Pp 1-10 (2023)
Abstract Background Osteoarthritis (OA) is a prevalent, chronic joint condition that commonly affects the knee and hip causing pain, impaired function, and reduced quality of life. As there is no cure, the main goal of treatment is to alleviate sympt
Externí odkaz: https://doaj.org/article/3b51838c28b94acfb7bda44d250645d8
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10
Akademický článek
Effect of Information Content and General Practitioner Recommendation to Exercise on Treatment Beliefs and Intentions for Knee Osteoarthritis: An Online Multi‐Arm Randomized Controlled Trial
Autor: Belinda J. Lawford, Kim L. Bennell, Michelle Hall, Thorlene Egerton, Fiona McManus, Karen E. Lamb, Rana S. Hinman
Publikováno v: ACR Open Rheumatology, Vol 5, Iss 1, Pp 17-27 (2023)
Objective To evaluate effects of general osteoarthritis (OA) information in addition to a treatment option grid and general practitioner (GP) recommendation to exercise on treatment beliefs and intentions. Methods An online randomized trial of 735 pe
Externí odkaz: https://doaj.org/article/398d5dfb55b54962840771f42ae3a4dc
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